tetano
Editor, Senior Moderator
Biosci Microbiota Food Health. 2015;34(4):67-76. Epub 2015 Jul 11.
[h=1]Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice.[/h] Kishino E[SUP]1[/SUP], Takemura N[SUP]1[/SUP], Masaki H[SUP]1[/SUP], Ito T[SUP]1[/SUP], Nakazawa M[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] This study examined the effects of lactosucrose (4[SUP]G[/SUP]-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4[SUP]+[/SUP] T cells in Peyer's patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity.
[h=4]KEYWORDS:[/h] cytotoxic activity; lactosucrose; mucosal immunity; secretory IgA; serum IgA; splenic NK cells
PMID: 26594606 [PubMed - as supplied by publisher] PMCID: PMC4654070 Free PMC Article
[h=1]Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice.[/h] Kishino E[SUP]1[/SUP], Takemura N[SUP]1[/SUP], Masaki H[SUP]1[/SUP], Ito T[SUP]1[/SUP], Nakazawa M[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] This study examined the effects of lactosucrose (4[SUP]G[/SUP]-β-D-galactosylsucrose) on influenza A virus infections in mice. First, the effects of lactosucrose on fermentation in the cecum and on immune function were investigated. In female BALB/c mice, lactosucrose supplementation for 6 weeks promoted cecal fermentation and increased both secretory IgA (SIgA) levels in feces and total IgA and IgG2a concentrations in serum. Both the percentage of CD4[SUP]+[/SUP] T cells in Peyer's patches and the cytotoxic activity of splenic natural killer (NK) cells increased significantly in response to lactosucrose. Next, we examined the effects of lactosucrose on low-dose influenza A virus infection in mice. After 2 weeks of dietary supplementation with lactosucrose, the mice were infected with low-dose influenza A virus. At 7 days post infection, a comparison with control mice showed that weight loss was suppressed, as were viral titers in the lungs. In the spleens of lactosucrose-fed mice, there was an increase in the percentage of NK cells. Lastly, mice fed lactosucrose were challenged with a lethal dose of influenza A virus. The survival rate of these mice was significantly higher than that of mice fed a control diet. These results suggested that lactosucrose supplementation suppresses influenza A virus infection by augmenting innate immune responses and enhancing cellular and mucosal immunity.
[h=4]KEYWORDS:[/h] cytotoxic activity; lactosucrose; mucosal immunity; secretory IgA; serum IgA; splenic NK cells
PMID: 26594606 [PubMed - as supplied by publisher] PMCID: PMC4654070 Free PMC Article