Terry L. Noah, Haibo Zhou, Hongtao Zhang, Katie Horvath, Carole Robinette, Matthew Kesic, Megan Meyer, David Diaz-Sanchez, and Ilona Jaspers
Diesel Exhaust Exposure and Nasal Response to Attenuated Influenza in Normal and Allergic Volunteers
Am. J. Respir. Crit. Care Med. published ahead of print on October 27, 2011 as doi:10.1164/rccm.201103-0465OC
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Conclusions: Short term exposure to diesel exhaust leads to increased eosinophil activation and increased virus quantity after virus inoculation in allergic rhinitics. This is consistent with previous literature suggesting a diesel "adjuvant" effect promoting allergic inflammation, and our data further suggest this change may be associated with reduced virus clearance.
