tetano
Editor, Senior Moderator
Diabetes Res Clin Pract
. 2020 Aug 24;108381.
doi: 10.1016/j.diabres.2020.108381. Online ahead of print.
J-shaped Association Between Fasting Blood Glucose Levels and COVID-19 Severity in Patients without Diabetes
Bing Zhu[SUP] 1 [/SUP], Shengwei Jin[SUP] 2 [/SUP], Lianpeng Wu[SUP] 3 [/SUP], Chenchan Hu[SUP] 3 [/SUP], Zhen Wang[SUP] 4 [/SUP], Le Bu[SUP] 1 [/SUP], Hang Sun[SUP] 1 [/SUP], Xingchun Wang[SUP] 1 [/SUP], Shen Qu[SUP] 5 [/SUP], Dong Chen[SUP] 6 [/SUP]
Affiliations
Abstract
Aims: coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients.
Methods: the multivariate stepwise binary logistic regression analysis was used to test the dose-response effects of FBG levels on the risk of severe and critical condition in COVID-19 patients.
Results: FBG levels were plotted in quintiles with set at < 4.74, 4.74-5.21, 5.21-5.78, 5.78-7.05, and ≧7.05 mmol/L. The constituent ratio of severe or critical cases in each FBG quintile was 20.7%, 1.7%, 13.8%, 27.1%, and 67.2%, respectively (P < 0.0001). When the second quintile was used as the reference, the adjusted odds ratios (AORs) (95%CI) for the risk of severe/critical condition in COVID-19 was 25.33(2.77, 231.64), 1.00 (Reference), 3.13(0.33, 29.67), 10.59(1.23, 91.24), 38.93(4.36, 347.48) per FBG quintile respectively (P < 0.001).
Conclusions: we provide evidence of J-shaped associations between FBG and risk of severe and critical condition in non-diabetes patients with COVID-19, with nadir at 4.74-5.78 mmol/L.
Keywords: Coronavirus disease 2019 (COVID-19); Fasting Blood Glucose; Glycemic target; Hyperglycemia; Hypoglycemia.
. 2020 Aug 24;108381.
doi: 10.1016/j.diabres.2020.108381. Online ahead of print.
J-shaped Association Between Fasting Blood Glucose Levels and COVID-19 Severity in Patients without Diabetes
Bing Zhu[SUP] 1 [/SUP], Shengwei Jin[SUP] 2 [/SUP], Lianpeng Wu[SUP] 3 [/SUP], Chenchan Hu[SUP] 3 [/SUP], Zhen Wang[SUP] 4 [/SUP], Le Bu[SUP] 1 [/SUP], Hang Sun[SUP] 1 [/SUP], Xingchun Wang[SUP] 1 [/SUP], Shen Qu[SUP] 5 [/SUP], Dong Chen[SUP] 6 [/SUP]
Affiliations
- PMID: 32853687
- DOI: 10.1016/j.diabres.2020.108381
Abstract
Aims: coronavirus disease 2019 (COVID-19) has become a recognized worldwide pandemic. Researchers now know that mortality from COVID-19 can be reduced through early prevention measures. This retrospective, multi-centered study of 293 COVID-19 patients without diabetes explores the association between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients.
Methods: the multivariate stepwise binary logistic regression analysis was used to test the dose-response effects of FBG levels on the risk of severe and critical condition in COVID-19 patients.
Results: FBG levels were plotted in quintiles with set at < 4.74, 4.74-5.21, 5.21-5.78, 5.78-7.05, and ≧7.05 mmol/L. The constituent ratio of severe or critical cases in each FBG quintile was 20.7%, 1.7%, 13.8%, 27.1%, and 67.2%, respectively (P < 0.0001). When the second quintile was used as the reference, the adjusted odds ratios (AORs) (95%CI) for the risk of severe/critical condition in COVID-19 was 25.33(2.77, 231.64), 1.00 (Reference), 3.13(0.33, 29.67), 10.59(1.23, 91.24), 38.93(4.36, 347.48) per FBG quintile respectively (P < 0.001).
Conclusions: we provide evidence of J-shaped associations between FBG and risk of severe and critical condition in non-diabetes patients with COVID-19, with nadir at 4.74-5.78 mmol/L.
Keywords: Coronavirus disease 2019 (COVID-19); Fasting Blood Glucose; Glycemic target; Hyperglycemia; Hypoglycemia.