tetano
Editor, Senior Moderator
Diabetes Metab Res Rev
. 2020 Jul 19;e3388.
doi: 10.1002/dmrr.3388. Online ahead of print.
Characteristics and outcomes of COVID-19 in hospitalized patients with and without diabetes
Abdallah Al-Salameh[SUP] 1 2 [/SUP], Jean-Philippe Lanoix[SUP] 3 [/SUP], Youssef Bennis[SUP] 4 [/SUP], Claire Andrejak[SUP] 5 [/SUP], Etienne Brochot[SUP] 6 [/SUP], Guillaume Deschasse[SUP] 7 [/SUP], Herv? Dupont[SUP] 8 [/SUP], Vincent Goeb[SUP] 9 [/SUP], Mait? Jaureguy[SUP] 10 [/SUP], Sylvie Lion[SUP] 11 [/SUP], Julien Maizel[SUP] 12 [/SUP], Julien Moyet[SUP] 8 [/SUP], Benoit Vaysse[SUP] 13 [/SUP], Rachel Desailloud[SUP] 1 2 [/SUP], Olivier Ganry[SUP] 14 [/SUP], Jean-Luc Schmit[SUP] 3 [/SUP], Jean-Daniel Lalau[SUP] 1 2 [/SUP]
Affiliations
Abstract
Aims: Coronavirus disease 2019 (COVID-19) is a rapidly progressing pandemic, with four million confirmed cases and 280,000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID-19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID-19 patients with vs. without diabetes.
Methods: All consecutive adult patients admitted to Amiens University Hospital (Amiens, France) with confirmed COVID-19 up until April 21[SUP]st[/SUP] , 2020, were included. The composite primary endpoint comprised admission to the intensive care unit (ICU) and death. Both components were also analyzed separately in a logistic regression analysis and a Cox proportional hazards model.
Results: A total of 433 patients (median age: 72; 238 (55%) men; diabetes: 115 (26.6%)) were included. Most of the deaths occurred in non-ICU units and among older adults. Multivariate analyses showed that diabetes was associated neither with the primary endpoint (odds ratio (OR): 1.12; 95% confidence interval (CI): 0.66-1.90) nor with mortality (hazard ratio: 0.73; 95%CI: 0.40-1.34) but was associated with ICU admission (OR: 2.06; 95%CI 1.09-3.92, p=0.027) and a longer length of hospital stay. Age was negatively associated with ICU admission and positively associated with death.
Discussion: Diabetes was prevalent in a quarter of the patients hospitalized with COVID-19; it was associated with a greater risk of ICU admission but not with a significant elevation in mortality. Further investigation of the relationship between COVID-19 severity and diabetes is warranted. This article is protected by copyright. All rights reserved.
Keywords: acute respiratory distress syndrome; coronavirus disease 2019 (COVID-19); diabetes; intensive care; mortality; outcome.
. 2020 Jul 19;e3388.
doi: 10.1002/dmrr.3388. Online ahead of print.
Characteristics and outcomes of COVID-19 in hospitalized patients with and without diabetes
Abdallah Al-Salameh[SUP] 1 2 [/SUP], Jean-Philippe Lanoix[SUP] 3 [/SUP], Youssef Bennis[SUP] 4 [/SUP], Claire Andrejak[SUP] 5 [/SUP], Etienne Brochot[SUP] 6 [/SUP], Guillaume Deschasse[SUP] 7 [/SUP], Herv? Dupont[SUP] 8 [/SUP], Vincent Goeb[SUP] 9 [/SUP], Mait? Jaureguy[SUP] 10 [/SUP], Sylvie Lion[SUP] 11 [/SUP], Julien Maizel[SUP] 12 [/SUP], Julien Moyet[SUP] 8 [/SUP], Benoit Vaysse[SUP] 13 [/SUP], Rachel Desailloud[SUP] 1 2 [/SUP], Olivier Ganry[SUP] 14 [/SUP], Jean-Luc Schmit[SUP] 3 [/SUP], Jean-Daniel Lalau[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32683744
- DOI: 10.1002/dmrr.3388
Abstract
Aims: Coronavirus disease 2019 (COVID-19) is a rapidly progressing pandemic, with four million confirmed cases and 280,000 deaths at the time of writing. Some studies have suggested that diabetes is associated with a greater risk of developing severe forms of COVID-19. The primary objective of the present study was to compare the clinical features and outcomes in hospitalized COVID-19 patients with vs. without diabetes.
Methods: All consecutive adult patients admitted to Amiens University Hospital (Amiens, France) with confirmed COVID-19 up until April 21[SUP]st[/SUP] , 2020, were included. The composite primary endpoint comprised admission to the intensive care unit (ICU) and death. Both components were also analyzed separately in a logistic regression analysis and a Cox proportional hazards model.
Results: A total of 433 patients (median age: 72; 238 (55%) men; diabetes: 115 (26.6%)) were included. Most of the deaths occurred in non-ICU units and among older adults. Multivariate analyses showed that diabetes was associated neither with the primary endpoint (odds ratio (OR): 1.12; 95% confidence interval (CI): 0.66-1.90) nor with mortality (hazard ratio: 0.73; 95%CI: 0.40-1.34) but was associated with ICU admission (OR: 2.06; 95%CI 1.09-3.92, p=0.027) and a longer length of hospital stay. Age was negatively associated with ICU admission and positively associated with death.
Discussion: Diabetes was prevalent in a quarter of the patients hospitalized with COVID-19; it was associated with a greater risk of ICU admission but not with a significant elevation in mortality. Further investigation of the relationship between COVID-19 severity and diabetes is warranted. This article is protected by copyright. All rights reserved.
Keywords: acute respiratory distress syndrome; coronavirus disease 2019 (COVID-19); diabetes; intensive care; mortality; outcome.