tetano
Editor, Senior Moderator
Expert Rev Vaccines. 2014 May 28:1-17. [Epub ahead of print]
Development of live attenuated influenza vaccines against pandemic influenza strains.
Coelingh KL1, Luke CJ, Jin H, Talaat KR.
Author information
Abstract
Avian and animal influenza viruses can sporadically transmit to humans, causing outbreaks of varying severity. In some cases, further human-to-human virus transmission does not occur, and the outbreak in humans is limited. In other cases, sustained human-to-human transmission occurs, resulting in worldwide influenza pandemics. Preparation for future pandemics is an important global public health goal. A key objective of preparedness is to gain an understanding of how to design, test, and manufacture effective vaccines that could be stockpiled for use in a pandemic. This review summarizes results of an ongoing collaboration to produce, characterize, and clinically test a library of live attenuated influenza vaccine strains (based on Ann Arbor attenuated Type A strain) containing protective antigens from influenza viruses considered to be of high pandemic potential.
KEYWORDS:
LAIV; intranasal influenza vaccine; live attenuated influenza vaccine; pandemic influenza vaccine
PMID:
24867587
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24867587
Development of live attenuated influenza vaccines against pandemic influenza strains.
Coelingh KL1, Luke CJ, Jin H, Talaat KR.
Author information
Abstract
Avian and animal influenza viruses can sporadically transmit to humans, causing outbreaks of varying severity. In some cases, further human-to-human virus transmission does not occur, and the outbreak in humans is limited. In other cases, sustained human-to-human transmission occurs, resulting in worldwide influenza pandemics. Preparation for future pandemics is an important global public health goal. A key objective of preparedness is to gain an understanding of how to design, test, and manufacture effective vaccines that could be stockpiled for use in a pandemic. This review summarizes results of an ongoing collaboration to produce, characterize, and clinically test a library of live attenuated influenza vaccine strains (based on Ann Arbor attenuated Type A strain) containing protective antigens from influenza viruses considered to be of high pandemic potential.
KEYWORDS:
LAIV; intranasal influenza vaccine; live attenuated influenza vaccine; pandemic influenza vaccine
PMID:
24867587
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24867587