tetano
Editor, Senior Moderator
Arch Pharm Res. 2012 Mar;35(4):633-8. Epub 2012 May 3.
Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors.
Kinger M, Park YD, Park JH, Hur MG, Jeong HJ, Park SJ, Lee WS, Kim SW, Yang SD.
Source
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongup, 580-185, Korea.
Abstract
A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC(50) value of 1.5 ∝M.
PMID:
22553055
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22553055
Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors.
Kinger M, Park YD, Park JH, Hur MG, Jeong HJ, Park SJ, Lee WS, Kim SW, Yang SD.
Source
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongup, 580-185, Korea.
Abstract
A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC(50) value of 1.5 ∝M.
PMID:
22553055
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22553055