tetano
Editor, Senior Moderator
Proc Natl Acad Sci U S A. 2018 Feb 20. pii: 201716771. doi: 10.1073/pnas.1716771115. [Epub ahead of print]
[h=1]Defining the sizes of airborne particles that mediate influenza transmission in ferrets.[/h] Zhou J[SUP]1[/SUP], Wei J[SUP]2[/SUP], Choy KT[SUP]1[/SUP], Sia SF[SUP]1[/SUP], Rowlands DK[SUP]3[/SUP], Yu D[SUP]1[/SUP], Wu CY[SUP]4[/SUP], Lindsley WG[SUP]5[/SUP], Cowling BJ[SUP]1[/SUP], McDevitt J[SUP]6[/SUP], Peiris M[SUP]7[/SUP], Li Y[SUP]2[/SUP], Yen HL[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 ?m, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
[h=4]KEYWORDS:[/h] airborne particles; airborne transmission; droplet transmission; ferrets; influenza virus
PMID: 29463703 DOI: 10.1073/pnas.1716771115
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[h=1]Defining the sizes of airborne particles that mediate influenza transmission in ferrets.[/h] Zhou J[SUP]1[/SUP], Wei J[SUP]2[/SUP], Choy KT[SUP]1[/SUP], Sia SF[SUP]1[/SUP], Rowlands DK[SUP]3[/SUP], Yu D[SUP]1[/SUP], Wu CY[SUP]4[/SUP], Lindsley WG[SUP]5[/SUP], Cowling BJ[SUP]1[/SUP], McDevitt J[SUP]6[/SUP], Peiris M[SUP]7[/SUP], Li Y[SUP]2[/SUP], Yen HL[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Epidemics and pandemics of influenza are characterized by rapid global spread mediated by non-mutually exclusive transmission modes. The relative significance between contact, droplet, and airborne transmission is yet to be defined, a knowledge gap for implementing evidence-based infection control measures. We devised a transmission chamber that separates virus-laden particles by size and determined the particle sizes mediating transmission of influenza among ferrets through the air. Ferret-to-ferret transmission was mediated by airborne particles larger than 1.5 ?m, consistent with the quantity and size of virus-laden particles released by the donors. Onward transmission by donors was most efficient before fever onset and may continue for 5 days after inoculation. Multiple virus gene segments enhanced the transmissibility of a swine influenza virus among ferrets by increasing the release of virus-laden particles into the air. We provide direct experimental evidence of influenza transmission via droplets and fine droplet nuclei, albeit at different efficiency.
[h=4]KEYWORDS:[/h] airborne particles; airborne transmission; droplet transmission; ferrets; influenza virus
PMID: 29463703 DOI: 10.1073/pnas.1716771115
Free full text