tetano
Editor, Senior Moderator
Cytokine
. 2022 Feb 10;152:155826.
doi: 10.1016/j.cyto.2022.155826. Online ahead of print.
SARS-CoV-2 infection causes intestinal cell damage: Role of interferon's imbalance
Stefany Guimarães Sousa[SUP] 1 [/SUP], Antônio Kleiton de Sousa[SUP] 2 [/SUP], Cynthia Maria Carvalho Pereira[SUP] 3 [/SUP], Anna Sofia Miranda Loiola Araújo[SUP] 3 [/SUP], Diva de Aguiar Magalhães[SUP] 1 [/SUP], Tarcisio Vieira de Brito[SUP] 3 [/SUP], André Luiz Dos Reis Barbosa[SUP] 4 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the newly emerging lung disease pandemic COVID-19. This viral infection causes a series of respiratory disorders, and although this virus mainly infects respiratory cells, the small intestine can also be an important site of entry or interaction, as enterocytes highly express in angiotensin-2 converting enzyme (ACE) receptors. There are countless reports pointing to the importance of interferons (IFNs) with regard to the mediation of the immune system in viral infection by SARS-CoV-2. Thus, this review will focus on the main cells that make up the large intestine, their specific immunology, as well as the function of IFNs in the intestinal mucosa after the invasion of coronavirus-2.
Keywords: Cytokines; Interferons; SARS-CoV-2 infection.
. 2022 Feb 10;152:155826.
doi: 10.1016/j.cyto.2022.155826. Online ahead of print.
SARS-CoV-2 infection causes intestinal cell damage: Role of interferon's imbalance
Stefany Guimarães Sousa[SUP] 1 [/SUP], Antônio Kleiton de Sousa[SUP] 2 [/SUP], Cynthia Maria Carvalho Pereira[SUP] 3 [/SUP], Anna Sofia Miranda Loiola Araújo[SUP] 3 [/SUP], Diva de Aguiar Magalhães[SUP] 1 [/SUP], Tarcisio Vieira de Brito[SUP] 3 [/SUP], André Luiz Dos Reis Barbosa[SUP] 4 [/SUP]
Affiliations
- PMID: 35158258
- DOI: 10.1016/j.cyto.2022.155826
Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the newly emerging lung disease pandemic COVID-19. This viral infection causes a series of respiratory disorders, and although this virus mainly infects respiratory cells, the small intestine can also be an important site of entry or interaction, as enterocytes highly express in angiotensin-2 converting enzyme (ACE) receptors. There are countless reports pointing to the importance of interferons (IFNs) with regard to the mediation of the immune system in viral infection by SARS-CoV-2. Thus, this review will focus on the main cells that make up the large intestine, their specific immunology, as well as the function of IFNs in the intestinal mucosa after the invasion of coronavirus-2.
Keywords: Cytokines; Interferons; SARS-CoV-2 infection.
