tetano
Editor, Senior Moderator
J Immunol. 2013 Jun 21. [Epub ahead of print]
Cutting Edge: Heterosubtypic Influenza Infection Antagonizes Elicitation of Immunological Reactivity to Hemagglutinin.
Nayak JL, Alam S, Sant AJ.
Source
Division of Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642.
Abstract
Influenza-specific immunity in humans is unique because there are repeated exposures to viral strains containing genetically conserved epitopes recruiting memory CD4 T cells and novel epitopes stimulating naive CD4 T cells, possibly resulting in competition between memory and naive lymphocytes. In this study, we evaluated the effect of this competition on CD4 T cell and B cell response specificity using a murine model of sequential influenza infection. We found striking and selective decreases in CD4 T cell reactivity to nonconserved hemagglutinin (HA) epitopes following secondary influenza infection. Surprisingly, this shift in CD4 T cell specificity was associated with dramatic decreases in HA-specific Ab. These results suggest that repeated exposure to influenza viruses and vaccines containing conserved internal proteins may have unintended and negative consequences on the ability to induce HA-specific Ab to novel pandemic strains of influenza. These finding could have important implications on pandemic influenza preparedness strategies.
PMID:
23794632
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23794632
Cutting Edge: Heterosubtypic Influenza Infection Antagonizes Elicitation of Immunological Reactivity to Hemagglutinin.
Nayak JL, Alam S, Sant AJ.
Source
Division of Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642.
Abstract
Influenza-specific immunity in humans is unique because there are repeated exposures to viral strains containing genetically conserved epitopes recruiting memory CD4 T cells and novel epitopes stimulating naive CD4 T cells, possibly resulting in competition between memory and naive lymphocytes. In this study, we evaluated the effect of this competition on CD4 T cell and B cell response specificity using a murine model of sequential influenza infection. We found striking and selective decreases in CD4 T cell reactivity to nonconserved hemagglutinin (HA) epitopes following secondary influenza infection. Surprisingly, this shift in CD4 T cell specificity was associated with dramatic decreases in HA-specific Ab. These results suggest that repeated exposure to influenza viruses and vaccines containing conserved internal proteins may have unintended and negative consequences on the ability to induce HA-specific Ab to novel pandemic strains of influenza. These finding could have important implications on pandemic influenza preparedness strategies.
PMID:
23794632
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23794632