tetano
Editor, Senior Moderator
Curr Mol Med
. 2020 Jul 13.
doi: 10.2174/1566524020666200713175426. Online ahead of print.
NPC1 as a Modulator of Disease Severity and Viral Entry of Sars-CoV-2
Cecilia Vial[SUP] 1 [/SUP], Juan Francisco Calder?n[SUP] 1 [/SUP], Andr?s D Klein[SUP] 1 [/SUP]
Affiliations
Abstract
The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endolysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored.
Keywords: COVID-19; Niemann-Pick C1; SARS-Cov-2; drug repurposing; infection.; modifier gene;
. 2020 Jul 13.
doi: 10.2174/1566524020666200713175426. Online ahead of print.
NPC1 as a Modulator of Disease Severity and Viral Entry of Sars-CoV-2
Cecilia Vial[SUP] 1 [/SUP], Juan Francisco Calder?n[SUP] 1 [/SUP], Andr?s D Klein[SUP] 1 [/SUP]
Affiliations
- PMID: 32660402
- DOI: 10.2174/1566524020666200713175426
Abstract
The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic variants in NPC1, which encodes for the endolysosomal Niemann-Pick type C1 protein, restricts the host-range of viruses in bats and susceptibility to infections in humans. Lack of NPC1 and its pharmacological suppression inhibits many viral infections including SARS-CoV-1 and Type I Feline Coronavirus Infection. Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored.
Keywords: COVID-19; Niemann-Pick C1; SARS-Cov-2; drug repurposing; infection.; modifier gene;