tetano
Editor, Senior Moderator
Curr Mol Med
. 2020 Nov 12.
doi: 10.2174/1566524020999201113102145. Online ahead of print.
Do genetic factors predispose people to COVID-19: A review article
Ava Nasrolahi[SUP] 1 [/SUP], Karimeh Haghani[SUP] 2 [/SUP], Ali Gheysarzadeh[SUP] 3 [/SUP], Salar Bakhtiyari[SUP] 2 [/SUP]
Affiliations
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) has become a threat to human life and society. Scientists and clinicians are struggling with the intrusive SARS-CoV-2 virus to enhance their knowledge about its pathogenesis and find an effective medicine and vaccine to combat its complications. Till now, they have learned that this SARS-CoV-2 has not infected all people exposed to this virus, and also severe respiratory illnesses have not been observed in all infected patients. Patients over 65 or with underlying diseases are more vulnerable to develop severe disease. Based on this premise, a high challengeable question is why some people are more susceptible to this virus and others are not. The present study was aimed to reviewthe current information which explains the broad spectrum of COVID-19 presentation.Herewe discussed that how genetic background, immune system, underlying disease, smokingstatus as well as age, race, and gender affect COVID-19 susceptibility.
Keywords: Age; COVID-19; Gender; Genetic susceptibility; Immune system; Race; SARS-CoV-2; Smoking status; Underlying diseases.
. 2020 Nov 12.
doi: 10.2174/1566524020999201113102145. Online ahead of print.
Do genetic factors predispose people to COVID-19: A review article
Ava Nasrolahi[SUP] 1 [/SUP], Karimeh Haghani[SUP] 2 [/SUP], Ali Gheysarzadeh[SUP] 3 [/SUP], Salar Bakhtiyari[SUP] 2 [/SUP]
Affiliations
- PMID: 33191884
- DOI: 10.2174/1566524020999201113102145
Abstract
The pandemic of coronavirus disease 2019 (COVID-19) has become a threat to human life and society. Scientists and clinicians are struggling with the intrusive SARS-CoV-2 virus to enhance their knowledge about its pathogenesis and find an effective medicine and vaccine to combat its complications. Till now, they have learned that this SARS-CoV-2 has not infected all people exposed to this virus, and also severe respiratory illnesses have not been observed in all infected patients. Patients over 65 or with underlying diseases are more vulnerable to develop severe disease. Based on this premise, a high challengeable question is why some people are more susceptible to this virus and others are not. The present study was aimed to reviewthe current information which explains the broad spectrum of COVID-19 presentation.Herewe discussed that how genetic background, immune system, underlying disease, smokingstatus as well as age, race, and gender affect COVID-19 susceptibility.
Keywords: Age; COVID-19; Gender; Genetic susceptibility; Immune system; Race; SARS-CoV-2; Smoking status; Underlying diseases.