tetano
Editor, Senior Moderator
Curr Med Sci
. 2021 Feb;41(1):14-23.
doi: 10.1007/s11596-021-2312-7. Epub 2021 Feb 13.
Self-reported Taste and Smell Disorders in Patients with COVID-19: Distinct Features in China
Jia Song[SUP] #[/SUP][SUP] 1 [/SUP], Yi-Ke Deng[SUP] #[/SUP][SUP] 1 [/SUP], Hai Wang[SUP] #[/SUP][SUP] 1 [/SUP], Zhi-Chao Wang[SUP] 1 [/SUP], Bo Liao[SUP] 1 [/SUP], Jin Ma[SUP] 1 [/SUP], Chao He[SUP] 1 [/SUP], Li Pan[SUP] 1 [/SUP], Yang Liu[SUP] 1 [/SUP], Isam Alobid[SUP] 2 [/SUP], De-Yun Wang[SUP] 3 [/SUP], Ming Zeng[SUP] 4 [/SUP], Joaquim Mullol[SUP] 5 [/SUP], Zheng Liu[SUP] 6 [/SUP]
Affiliations
Abstract
Last December 2019, a cluster of viral pneumonia cases identified as coronavirus disease 2019 (COVID-19) was reported in Wuhan, China. We aimed to explore the frequencies of nasal symptoms in patients with COVID-19, including loss of smell and taste, as well as their presentation as the first symptom of the disease and their association with the severity of COVID-19. In this retrospective study, 1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital, Wuhan. Demographic data, laboratory values, comorbidities, symptoms, and numerical rating scale scores (0-10) of nasal symptoms were extracted from the hospital medical records, and confirmed or reevaluated by the telephone follow-up. From patients (n=1172) completing follow-up, 199 (17%) subjects had severe COVID-19 and 342 (29.2%) reported nasal symptoms. 20.6% COVID-19 patients had loss of taste (median score=6), while 11.4% had loss of smell (median score=5). Loss of taste scores, but not loss of smell scores, were significantly increased in severe vs. non-severe COVID-19 patients. Interleukin (IL)-6 and lactose dehydrogenase (LDH) serum levels were positively correlated with loss of taste scores. About 80% of COVID-19 patients recovered from smell and taste dysfunction in 2 weeks. In this cohort, only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of COVID-19. Most patients recovered smell and taste dysfunctions in 2 weeks.
Keywords: coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2; smell; taste.
. 2021 Feb;41(1):14-23.
doi: 10.1007/s11596-021-2312-7. Epub 2021 Feb 13.
Self-reported Taste and Smell Disorders in Patients with COVID-19: Distinct Features in China
Jia Song[SUP] #[/SUP][SUP] 1 [/SUP], Yi-Ke Deng[SUP] #[/SUP][SUP] 1 [/SUP], Hai Wang[SUP] #[/SUP][SUP] 1 [/SUP], Zhi-Chao Wang[SUP] 1 [/SUP], Bo Liao[SUP] 1 [/SUP], Jin Ma[SUP] 1 [/SUP], Chao He[SUP] 1 [/SUP], Li Pan[SUP] 1 [/SUP], Yang Liu[SUP] 1 [/SUP], Isam Alobid[SUP] 2 [/SUP], De-Yun Wang[SUP] 3 [/SUP], Ming Zeng[SUP] 4 [/SUP], Joaquim Mullol[SUP] 5 [/SUP], Zheng Liu[SUP] 6 [/SUP]
Affiliations
- PMID: 33582900
- DOI: 10.1007/s11596-021-2312-7
Abstract
Last December 2019, a cluster of viral pneumonia cases identified as coronavirus disease 2019 (COVID-19) was reported in Wuhan, China. We aimed to explore the frequencies of nasal symptoms in patients with COVID-19, including loss of smell and taste, as well as their presentation as the first symptom of the disease and their association with the severity of COVID-19. In this retrospective study, 1206 laboratory-confirmed COVID-19 patients were included and followed up by telephone one month after discharged from Tongji Hospital, Wuhan. Demographic data, laboratory values, comorbidities, symptoms, and numerical rating scale scores (0-10) of nasal symptoms were extracted from the hospital medical records, and confirmed or reevaluated by the telephone follow-up. From patients (n=1172) completing follow-up, 199 (17%) subjects had severe COVID-19 and 342 (29.2%) reported nasal symptoms. 20.6% COVID-19 patients had loss of taste (median score=6), while 11.4% had loss of smell (median score=5). Loss of taste scores, but not loss of smell scores, were significantly increased in severe vs. non-severe COVID-19 patients. Interleukin (IL)-6 and lactose dehydrogenase (LDH) serum levels were positively correlated with loss of taste scores. About 80% of COVID-19 patients recovered from smell and taste dysfunction in 2 weeks. In this cohort, only 1 out of 10 hospital admitted patients had loss of smell while 1 out of 5 reported loss of taste which was associated to severity of COVID-19. Most patients recovered smell and taste dysfunctions in 2 weeks.
Keywords: coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2; smell; taste.