tetano
Editor, Senior Moderator
Curr Med Chem
. 2022 Feb 16.
doi: 10.2174/0929867329666220216110931. Online ahead of print.
Perspectives and Prospects on mRNA Vaccine Development for COVID-19
Lihui Jin[SUP] 1 [/SUP], Zhenyuan Han[SUP] 2 [/SUP], Pengjun Zhao[SUP] 1 [/SUP], Kun Sun[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The current coronavirus disease 2019 (COVID-19) pandemic, since first reported in Wuhan, has inspired worldwide efforts to develop effective COVID-19 vaccination strategies. mRNA vaccines encoding COVID-19 antigens gain lead in this global race due to their high effectiveness and simple manufacturing process. Notably, two COVID-19 mRNA vaccines, mRNA-1273 and BNT162b2, have survived in clinical trials and been authorized for emergency use across a range of countries.
Summary: Recent advances on mRNA vaccine development for COVID-19 are discussed in this perspective, including sequence design, chemical modification, manufacturing process and in vivo delivery. Phase I to IV clinical trials of mRNA-1273 and BNT162b2 are then summarized, respectively.
Perspective: Using mRNA vaccines serves as a promising strategy to achieve mass vaccination in the COVID-19 pandemic. We hope that future studies of mRNA vaccine technology would overcome existing limitations and help people cope with COVID-19.
Keywords: BNT162b2; Coronavirus disease 2019 (COVID-19); chemical modifications; mRNA vaccine; mRNA-1273.
. 2022 Feb 16.
doi: 10.2174/0929867329666220216110931. Online ahead of print.
Perspectives and Prospects on mRNA Vaccine Development for COVID-19
Lihui Jin[SUP] 1 [/SUP], Zhenyuan Han[SUP] 2 [/SUP], Pengjun Zhao[SUP] 1 [/SUP], Kun Sun[SUP] 1 [/SUP]
Affiliations
- PMID: 35170403
- DOI: 10.2174/0929867329666220216110931
Abstract
Background: The current coronavirus disease 2019 (COVID-19) pandemic, since first reported in Wuhan, has inspired worldwide efforts to develop effective COVID-19 vaccination strategies. mRNA vaccines encoding COVID-19 antigens gain lead in this global race due to their high effectiveness and simple manufacturing process. Notably, two COVID-19 mRNA vaccines, mRNA-1273 and BNT162b2, have survived in clinical trials and been authorized for emergency use across a range of countries.
Summary: Recent advances on mRNA vaccine development for COVID-19 are discussed in this perspective, including sequence design, chemical modification, manufacturing process and in vivo delivery. Phase I to IV clinical trials of mRNA-1273 and BNT162b2 are then summarized, respectively.
Perspective: Using mRNA vaccines serves as a promising strategy to achieve mass vaccination in the COVID-19 pandemic. We hope that future studies of mRNA vaccine technology would overcome existing limitations and help people cope with COVID-19.
Keywords: BNT162b2; Coronavirus disease 2019 (COVID-19); chemical modifications; mRNA vaccine; mRNA-1273.