tetano
Editor, Senior Moderator
Cureus
. 2022 Apr 23;14(4):e24418.
doi: 10.7759/cureus.24418. eCollection 2022 Apr.
Graves' Disease Following COVID-19 Vaccination
Gurdeep Singh[SUP] 1 [/SUP], Timothy Howland[SUP] 2 [/SUP]
Affiliations
Abstract
Autoimmune endocrine diseases have been reported after influenza and the human papillomavirus vaccine, but there is limited data on autoimmune diseases after coronavirus disease 2019 (COVID-19) vaccination. Our report is about a 42-year-old Caucasian male and a 68-year-old Caucasian female who developed Graves' disease after receiving Moderna (Moderna, Inc., Cambridge, Massachusetts, United States) and Johnson & Johnson (Johnson & Johnson, New Brunswick, New Jersey, United States) vaccines, respectively. Both patients had no previous autoimmune thyroiditis and had normal thyroid function but developed hyperthyroidism characterized by suppressed thyroid-stimulating hormone (TSH), elevated free T4 level, and TSH receptor antibodies after vaccination. COVID-19 vaccines, either mRNA-based (Moderna) or non-mRNA-based (Johnson & Johnson), can cause Graves' disease. The clinical manifestations are similar to Graves' disease but without ocular manifestations.
Keywords: covid 19; covid-19 vaccine; graves´disease; johnson and johnson vaccine; moderna vaccine; mrna vaccine.
. 2022 Apr 23;14(4):e24418.
doi: 10.7759/cureus.24418. eCollection 2022 Apr.
Graves' Disease Following COVID-19 Vaccination
Gurdeep Singh[SUP] 1 [/SUP], Timothy Howland[SUP] 2 [/SUP]
Affiliations
- PMID: 35497078
- PMCID: PMC9038595
- DOI: 10.7759/cureus.24418
Abstract
Autoimmune endocrine diseases have been reported after influenza and the human papillomavirus vaccine, but there is limited data on autoimmune diseases after coronavirus disease 2019 (COVID-19) vaccination. Our report is about a 42-year-old Caucasian male and a 68-year-old Caucasian female who developed Graves' disease after receiving Moderna (Moderna, Inc., Cambridge, Massachusetts, United States) and Johnson & Johnson (Johnson & Johnson, New Brunswick, New Jersey, United States) vaccines, respectively. Both patients had no previous autoimmune thyroiditis and had normal thyroid function but developed hyperthyroidism characterized by suppressed thyroid-stimulating hormone (TSH), elevated free T4 level, and TSH receptor antibodies after vaccination. COVID-19 vaccines, either mRNA-based (Moderna) or non-mRNA-based (Johnson & Johnson), can cause Graves' disease. The clinical manifestations are similar to Graves' disease but without ocular manifestations.
Keywords: covid 19; covid-19 vaccine; graves´disease; johnson and johnson vaccine; moderna vaccine; mrna vaccine.