tetano
Editor, Senior Moderator
Cureus
. 2022 Oct 14;14(10):e30304.
doi: 10.7759/cureus.30304. eCollection 2022 Oct.
COVID-19 Vaccination-Induced Cholangiopathy and Autoimmune Hepatitis: A Series of Two Cases
Mansoor Zafar[SUP] 1 [/SUP], Katherine Gordon[SUP] 2 [/SUP], Lucia Macken[SUP] 2 [/SUP], Joe Parvin[SUP] 1 [/SUP], Simon Heath[SUP] 3 [/SUP], Max Whibley[SUP] 3 [/SUP], Jeremy Tibble[SUP] 4 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has been associated with significant morbidity and mortality. Following the introduction of vaccines, various side effects have been reported. Whilst those reported may be attributed to the vaccine itself, at times, it may simply incite an immunological phenomenon. We present a case series of two patients who presented with symptoms of yellowing of the eyes and the skin along with fatigue, and tiredness, following vaccination for COVID-19. The diagnosis of post COVID-19-vaccination related hepatitis is one of the fewer, less understood, yet reported side effects associated with significant morbidity. The diagnosis of COVID-19 vaccination-related cholangitis is an outcome reported here for the first time to the best of our knowledge. It was alarming that both patients did not have any significant past history of medical ailments. A prompt assessment followed by investigations including liver biopsy assisted in a timely understanding of the phenomenon with complete resolution of the symptoms.
Keywords: alt (alanine aminotransferase); c –reactive protein (crp); emergency medical service; hematoxylin & eosin; liver function tests (lfts); magnetic resonance cholangiopancreatography (mrcp); mrna.
. 2022 Oct 14;14(10):e30304.
doi: 10.7759/cureus.30304. eCollection 2022 Oct.
COVID-19 Vaccination-Induced Cholangiopathy and Autoimmune Hepatitis: A Series of Two Cases
Mansoor Zafar[SUP] 1 [/SUP], Katherine Gordon[SUP] 2 [/SUP], Lucia Macken[SUP] 2 [/SUP], Joe Parvin[SUP] 1 [/SUP], Simon Heath[SUP] 3 [/SUP], Max Whibley[SUP] 3 [/SUP], Jeremy Tibble[SUP] 4 [/SUP]
Affiliations
- PMID: 36258805
- PMCID: PMC9565316
- DOI: 10.7759/cureus.30304
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has been associated with significant morbidity and mortality. Following the introduction of vaccines, various side effects have been reported. Whilst those reported may be attributed to the vaccine itself, at times, it may simply incite an immunological phenomenon. We present a case series of two patients who presented with symptoms of yellowing of the eyes and the skin along with fatigue, and tiredness, following vaccination for COVID-19. The diagnosis of post COVID-19-vaccination related hepatitis is one of the fewer, less understood, yet reported side effects associated with significant morbidity. The diagnosis of COVID-19 vaccination-related cholangitis is an outcome reported here for the first time to the best of our knowledge. It was alarming that both patients did not have any significant past history of medical ailments. A prompt assessment followed by investigations including liver biopsy assisted in a timely understanding of the phenomenon with complete resolution of the symptoms.
Keywords: alt (alanine aminotransferase); c –reactive protein (crp); emergency medical service; hematoxylin & eosin; liver function tests (lfts); magnetic resonance cholangiopancreatography (mrcp); mrna.