tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2014 Feb 13;10(2). [Epub ahead of print]
Cross-conservation of T-cell epitopes: Now even more relevant to (H7N9) influenza vaccine design.
De Groot AS1, Moise L1, Liu R2, Gutierrez AH3, Terry F3, Koita OA4, Ross TM5, Martin W3.
Author information
Abstract
A novel avian-origin H7N9 influenza strain emerged in China in April 2013. Since its re-emergence in October-November 2013, the number of reported cases has accelerated; more than 280 laboratory-confirmed cases and 60 deaths (case fatality rate of 22%) have been reported. The resurgence of H7N9 has re-emphasized the importance of making faster and more effective influenza vaccines than those that are currently available. Recombinant H7 hemagglutinin (H7-HA) vaccines have been produced, addressing the first problem. Unfortunately these recombinant subunit vaccine products appear to have failed to address the second problem, influenza vaccine efficacy. Reported unadjuvanted H7N9 vaccine seroconversion rates were between 6% and 16%, nearly 10-fold lower than rates for unadjuvanted vaccine seroconversion to standard H1N1 monovalent (recombinant) vaccine (89% to pandemic H1N1). Could this state of affairs have been predicted? As it turns out, yes, and it was. 8In that previous analysis of available H7-HA sequences, we found fewer T-cell epitopes per protein than expected, and predicted that H7-HA-based vaccines would be much less antigenic than recent seasonal vaccines. Novel approaches to developing a more immunogenic HA were offered for consideration at the time, and now they appear to be even more relevant. More effective H7N9 influenza vaccines can be produced, provided that the role of T-cell epitopes is carefully considered, and accumulated knowledge about the importance of cross-conserved epitopes between viral subtypes is applied to the design of those vaccines.
KEYWORDS:
CD4+ T cell, H1N1, H7N9, T cell, T cell epitope, T helper, avian-origin, cell-mediated immunity, genome, hemagglutinin, influenza, recombinant protein
PMID:
24525618
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24525618
Cross-conservation of T-cell epitopes: Now even more relevant to (H7N9) influenza vaccine design.
De Groot AS1, Moise L1, Liu R2, Gutierrez AH3, Terry F3, Koita OA4, Ross TM5, Martin W3.
Author information
Abstract
A novel avian-origin H7N9 influenza strain emerged in China in April 2013. Since its re-emergence in October-November 2013, the number of reported cases has accelerated; more than 280 laboratory-confirmed cases and 60 deaths (case fatality rate of 22%) have been reported. The resurgence of H7N9 has re-emphasized the importance of making faster and more effective influenza vaccines than those that are currently available. Recombinant H7 hemagglutinin (H7-HA) vaccines have been produced, addressing the first problem. Unfortunately these recombinant subunit vaccine products appear to have failed to address the second problem, influenza vaccine efficacy. Reported unadjuvanted H7N9 vaccine seroconversion rates were between 6% and 16%, nearly 10-fold lower than rates for unadjuvanted vaccine seroconversion to standard H1N1 monovalent (recombinant) vaccine (89% to pandemic H1N1). Could this state of affairs have been predicted? As it turns out, yes, and it was. 8In that previous analysis of available H7-HA sequences, we found fewer T-cell epitopes per protein than expected, and predicted that H7-HA-based vaccines would be much less antigenic than recent seasonal vaccines. Novel approaches to developing a more immunogenic HA were offered for consideration at the time, and now they appear to be even more relevant. More effective H7N9 influenza vaccines can be produced, provided that the role of T-cell epitopes is carefully considered, and accumulated knowledge about the importance of cross-conserved epitopes between viral subtypes is applied to the design of those vaccines.
KEYWORDS:
CD4+ T cell, H1N1, H7N9, T cell, T cell epitope, T helper, avian-origin, cell-mediated immunity, genome, hemagglutinin, influenza, recombinant protein
PMID:
24525618
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24525618