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Critical Thinking Skills Assist Sound Decision Making

Re: How to Think Analytically

Re: How to Think Analytically

In response to mixin's post.... #12

Mixin, Thanks for the welcome. I have been an avid Flutrackers fan since April 2006. I looked up this word 'lurking' and it is accurate. It sounds kind of bad, but is actually a good thing to do, to get the flavor of the forum. I feel it was respectful to withhold my views until I could be confident that I was also bringing some value to the table. I viewed a couple of other sites, but FT is tops. BTW this is the first forum that I have contributed to, so I am still very much learning the ropes. I had drafted a couple of other posts, but didn't submit them because I didn't think my writing was sufficiently cohesive. I'm probably still a lot better at reading than writing, but I am resolved to work on that.
Regarding the Dr. Niman vs 'other sources', I am sorry if it felt personal, because that is not my interest. I try to be mindful of the readership in general. I was in that readership for ~22 months, and want to provide; information, perspective, and humor for those who are 'extending themselves' to face something unpleasant, and learn something new, as I was (and still am).
Re: Global Avian Influenza Network for Surveillance (GAINS). I have been to their website. I have not read very deeply there, so I can not comment, but I will keep that resource in mind. From what you know of them, do you see any venues for benefit to FT (or benefit to them from something FT has to offer)? Have you seen any indication that they are aware of FT and how much relevant information FT has amassed? The GAINS web presence is maintained by the Wildlife Conservation Society (WCS), and includes links to two other WCS web domains. From what I saw, their approach is both centric and bias-free. An example is the opening paragraph on their homepage..... "The economic losses associated with highly pathogenic avian influenza across parts of Asia, Europe and Africa are estimated to be in the billions of dollars. As the virus moves between wild birds, domesticated poultry and people, the potential for a pandemic the likes of the 1918 influenza epidemic that killed an estimated 40 million people worldwide increases. The impacts to biodiversity have rarely been addressed."

Thanks again for the welcome!
///Read///
 
Re: How to Think Analytically

Re: How to Think Analytically

///read///,
I'm glad to see you back again and I can see that you really do put a lot of thought into your posts.
Regarding your advice... let me return the favor in this matter
BTW this is the first forum that I have contributed to, so I am still very much learning the ropes
People at this forum exhibit extremely good behavior. There are many, many internet forums where a very first post advising existing members on how to think would get the hair flamed right off the new member's head. If you decide to join other forums, you may want to tread lightly until people get to know you a little.:)

Your second group of postings had very good points and appeared well balanced until you said this
That's just a bunch of 'hissy-fit' finger pointing,
and then you lost me.

As far as GAINS and FT: ?
 
Re: How to Think Analytically

Re: How to Think Analytically

Prompted by Canagica's 'bird ID' post....
I apologize for generalizing. I should have said 'SOME' conservation groups, because not all are in denial.
In theory, I agree with you.
You posted: "I would propose that learning "how [HPAI H5N1] is spread" is one of the most important parts to efficiently utilizing resources to combat its spread." I agree. I just think that already happened. We do already know how it is spread. Good-enough anyway. We have known that it infects wild birds and poultry and it doesn't matter which one is 'more to blame'. We have already been utilizing resources on all fronts, at the same time, and it is still expanding in every way that matters. In geographic spread, within and between countries and continents. In numbers of species (including mammals) that it infects. In genetic diversity, of multiple clades, which can then recombine, reassort, and co-infect. In genetic complexity, such as Tamiflu resistance. It has stayed ahead of massive vaccination campaigns (Egypt for example). It has turned the vaccination 'tables' against us by picking up its own 'forgotten' ( from years ago )cleavage site, by infecting vaccinated poultry.
By doing that, it is like a fire that has gained the ability to burn the water that's 'dousing' it.
It has become so widespread, and constant, that it has been dropping out of the news media in countries distant from its ravages. This is not good, because that detracts from funding to solve it. It is dropping below the radar in the countries most capable of mounting a defense, and making inroads in the countries least able to combat it. Makes you wonder if this disease has a conscious, thinking ability, doesn't it. The word insidious comes to mind. If you think about it, this disease is a Weapon of Mass Destruction (WMD) and it is currently active. Terrorists only wish they could accomplish as much as this disease has already, (with ease and alacrity) and the fireworks haven't even begun.
On the one hand, species specificity may be very important, and even pivotal. If for instance, we find that a single species of bird is vulnerable that had not previously shown susceptibility, it might just be one of the few birds that travel to Australia. That could be hugely significant to masses of animals of many types, including humans, in Australia.
On the other hand, it may be like knowing which brand of matches was used to start a destructive fire. The important thing is putting out the fire, and that bit of knowledge isn't going to make a difference. I don't see where distinguishing between two species is important when the disease has been proven to infect dozens of species. Nice, yes. Curious about it, yes. Relevant to the big picture? Maybe, or maybe not. I don't deem to know, and that's why I deferred to the virologists. You also wouldn't want to involve bird experts if they weren't adding value to the process, (too many cooks....slows down? .... the soup). My default position is to be inclusive, and my intent was to start a brainstorm at ways that people can put their differences aside and pull together.
I've heard that "In theory, there is no difference between theory and practice. In practice, there is." ;-)
Regards, ///Read///
 
Re: How to Think Analytically

Re: How to Think Analytically

Prompted by Canagica's 'negative data' post ....but written with 'everyone' in mind. thanks Canagica !
You raise several good issues, that indicate 'critical thinking' skills, excellent.
I think that the only place where 0s and Xs are equal is in tic-tac-toe, and then only in a multi-game series, played fairly. ;- )

ISSUES LIST:
1) Validity of 0s, vs validity of Xs. If both are valid, are they equally important?
2) The process of analyzing data has several steps, any of which can be flawed for multiple reasons.
3) For any individual to discern the credibility of (or to discredit) a given report, requires that person to be familiar with the; methods, execution, and personal competence of the researchers. This is why we value peer-reviewed journals, and certain experts who we have a 'history of credibility' with.
4) I would like to add a fourth issue, that I hope you will agree with ( you may have implied it when talking about 'opinions'). That is the use of logic and reasoning.

DISCUSSION:
1) Validity of 0s, vs validity of Xs. If both are valid, are they equally important?
When testing of birds for disease is discussed, the word sensitivity is often used. It has a common meaning, and a technical meaning. The technical usage is paired with the term specificity. These paired terms are used in many of the sciences (including medical), I just happened to find a good definition in the glossary at the National Institutes of Health (U.S. Govt.). Before we go there, it's important to clarify the usage of the terms negative and positive. If we are talking about an individual, or group of individuals, positive means infected (which is not upbeat or favorable at all, quite the opposite). Negative means the test did not find infection (finally, we can hooray for negatives). When we are talking about TESTING of an individual or a group of individuals, positive means that the specific test we are evaluating INDICATED infection, and negative means that specific test INDICATED no infection. Whether the individual was actually positive or negative for infection is reflected in the additional qualifiers TRUE and FALSE. These two definitions (below) assume that a) you are testing either a whole population, or some sample (randomly selected portion) of a population. b) Some infection is present.
From http://www.nlm.nih.gov/nichsr/hta101/ta101014.html
Sensitivity: an operating characteristic of a diagnostic test that measures the ability of a test to detect a disease (or condition) when it is truly present. Sensitivity is the proportion of all diseased patients for whom there is a positive test, determined as: [true positives ? (true positives + false negatives)]. (Contrast with specificity.)
Specificity: an operating characteristic of a diagnostic test that measures the ability of a test to exclude the presence of a disease (or condition) when it is truly not present. Specificity is the proportion of non-diseased patients for whom there is a negative test, expressed as: [true negatives ? (true negatives + false positives)]. (Contrast with sensitivity.)

Fortunately, we can dispense with talking about specificity since we are not concerned with testing that says there are many more infections, than we can account for, by symptoms of disease (including death). Note, in my post about 'negative data' that it is easy to see we're not in danger of finding the disease where it isn't, and much likelihood of not finding it when it is present. I listed some of the causal agents of not finding disease. If we can agree that it can be difficult, especially in 'field' conditions, to run large numbers of tests, on sometimes un-cooperative 'test subjects', without one or more of these hazards spoiling the results, then we have a reason to talk about sensitivity.
The back-story. Wild birds usually die in a random, and geographically distributed fashion. They are often found and consumed by predators. It happens almost silently, and attracts little attention. When large numbers of birds die at a single location, and almost at the same time, it may attract attention. When multiple species of birds died by the hundreds and thousands, at Qinghai Lake in the spring of 2005, it attracted attention. Since then, there have been many more die-offs that have attracted attention, and testing for disease, since there wasn't some other explanation, such as weather, or poison.

The logic explanation:
When tests of dead birds indicate disease, but tests of live birds (in the same population) don't, then it can be said that the test is not sufficiently sensitive to 'pick up on' the levels of pathogens in the live birds. They (testing teams) go to an area ( perhaps a lake) where wild birds are dying in unusually large numbers. They test some of the healthy birds and show zero infected. The next day, there are more dead birds. They test again and find zero infected. The next day, there are more dead birds. The dead birds are the Xs. The negative test results are the 0s. Which are you going to believe, the empirical data, the dead birds (which do test positive), or the same tests done on live birds that simply 'miss' detecting it? The question is; is H5N1 infecting this bird population? Yes or No? Anybody not sure? O.K. I'll make it even easier.... The tests require that the concentration of pathogens in the test-substance be above a certain level for the test to register a 'positive'. Again, Yes or No?
Tests are most useful and appropriate when empirical evidence is either difficult or impossible to acquire (occult disease, avoiding invasive procedures such as surgery etc.). They by no means should be conferred credibility in conflict with hard evidence. Apparently, there are arguments circulating out there, that refer to the numerous test 0s to steer attention (and blame) away from the contributory role of wild birds in the transmission of H5N1. Highly inappropriate, does not help to find solutions to the problem (sweeping it under the rug).
The half-math explanation:
Focusing on the sensitivity equation [true positives ? (true positives + false negatives)], it is easy to see that if you have one or more false negatives, then (true positives + false negatives) will always be greater than true positives alone. So unless a test is absolutely perfect, (and nothing is) the sensitivity will always be less than one ( 1, aka unity). EX. [ 80 / (80 + 7) ] = [ 80 / 87 ] = 0.919. Now that we have a yardstick, let's measure what has been happening in these bird 'assays'.
We can put some values into the formula. These will be half-math values, so we still have our logic-caps on here. First, we have irrefutable evidence that excessive deaths (far more than normal attrition) were occurring (= some number) . So, if the testers were finding 0 positives, therefore the number of positives they found that were truly positive is also 0. The formula becomes [ 0 / ( 0 + some number )] . We know that 0 / any number is still 0, so the sensitivity of that particular test, done on live birds = zero.
Let's say that the results were 'fudged', or 'interpreted' in a biased manner. Perhaps some results were 'on the line', and they declared them to be negatives. If we re-interpret those, and say there were a 'few' of them, the formula becomes [ a few / ( a few + some number )] . If they did this, then they could say " the test sensitivity was _____ ", where _____ = some small fractional value (perhaps 0.25, or 0.38). But then they would have to give up their claim that "there were none". It is not a good trade from their perspective, because a sensitivity of 0.25 is dismal. If you go to the doctor to find out if you have an infection or disease, you want that test 'sensitivity' to be roughly about 0.9999999 or better. :-)

The full-math explanation:
So putting some made-up numbers in for the purpose of an example, let's say there are on average, 10,000 geese at the remote lake. Each day 400 die (that's 4%). Each day, 400 more geese arrive (keeps the math constant). The teams test 100 birds, find zero infected. They should have found 4, in a random sample of sufficient size. Sensitivity = zero.

Like this... Initial scenario where they find 0. Sensitivity = [ 0 / ( 0 + 4)], so sensitivity = 0.00

Same scenario except they find 1. Sensitivity = [ 1 / ( 1 + 3)], so sensitivity = 0.25

Same scenario except they find 2. Sensitivity = [ 2 / ( 2 + 2 )], so sensitivity = 0.50

Same scenario except they find 3. Sensitivity = [ 3 / ( 3 + 1 )], so sensitivity = 0.75

Same scenario except they find 4. Sensitivity = [ 4 / ( 4 + 0 )], so sensitivity = 1.00

Now that we are on the same page regarding sensitivity, do you think the 'none found' 'data zeros' are valid, or are they an artifact of a test that is not sensitive enough? If they are, would they even be important in the face of birds dying en-masse? Which is a perfect segway into the second issue.

2) The process of analyzing data has several steps, any of which can be flawed for multiple reasons.
I don't know the answer to this, so these are just questions for thought:
a) Who is doing the data collecting? .... recording? ..... interpreting?..... and reporting?
b) Are they impartial scientists, or do they have biases, or agends, or mandates 'from above'?
c) What are the initial assumptions? Often they can color the answer.
d) Even with the best of intentions, what are the real-world difficulties in being objective? The outback is a long way from the controlled environment of a laboratory.
e) Is the data correct, in an absolute sense, but taken 'out of context'?
f) .........

Have you ever played the kid's game called 'telephone'? It becomes obvious (and sometimes quite amusing) that the more links there are in a communication chain, the less reliable the output may be. I tend to give greater credibility to; first-hand observations, news reports, and information from several independent sources which all concur, and less credibility to; sales 'hype', publicity 'plays', political 'platforms', and proselytizing 'propaganda'. Segway to 3)...

3) For any individual to discern the credibility of (or to discredit) a given report, requires that person to be familiar with the; methods, execution, and personal competence of the researchers.
This invites an entire seperate post, but not for today..... short response is, practice 'critical thinking'. Also, perhaps there is as much art as science, and requires developing a sense of 'smell'. On this particular topic, it begs for tracking down the referenced test, and how the people quoting them 'rolled up' the numbers.

4) I would like to add a fourth issue, that I hope you will agree with ( you may have implied it when talking about 'opinions'). That is the use of logic and reasoning.
Some of this is in the examples above, but let's also take the question about efficacy of the tests. A poor demonstration of sensitivity 'in the field' does not invalidate a test method completely. It may simply say 'this works on human patients in hospital, who are more than 2 days after exposure, and have progressed to the point of fever and labored breathing'. It may also say 'this doesn't work on wild birds, because they either carry the disease at such low levels of virus that it is both asymptomatic and below the test threshold, or their resistance gets low and then it kills them in a few hours'. The window (in terms of time or in rising 'titers' of infectious agent, or antibodies) is too narrow in some instances, for this test to be effective.

Thanks again... ///Read///
 
Re: How to Think Analytically

Re: How to Think Analytically

Mixin, Hi again. Thanks for the compliment on the amount of thought that my posts convey.
Thanks for the advice too.
It is not my interest to make anything I post here personal, (this post is an exception) quite to the contrary, I write with all of the readers in mind. In fact, you say you are returning the favor, but I don't recall having given you any advice...
I agree that "People at this forum exhibit extremely good behavior". I like that. I try to emulate that.
Just in case any of the other readers got the same (mis) impressions, I feel compelled to attempt to clear up a possible misunderstanding or two.....

1) About the first quote: I did not choose the title "How To Think Analytically", Florida1 chose that to provide my first posts a new thread. I had posted to "Negative thinking: H5N1 in pakistan" having to with "spread due to migratory birds". I agree with her that my posts were more general, and constituted a hijack of the previous thread. Next time I will know to do that. If I chose the thread title, I may have chosen " Critical Thinking Skills Assist Sound Decision Making " or something similar, but this title is 'close enough', and I'm glad for her help.

2) I am not writing with just existing members in mind.. I am writing for all of the readers. I am writing to help people make decisions that may effect their preparedness, and survival. When I first got involved in H5N1, it was a confusing jumble of data and opinions. I have found a way that helps me to make sense of it, and I am trying to share that with others.

3) You make a very good point about others getting to know me. My fault. After reading here for ~22 months, I felt that I had come to know the members, and felt like a part of the community already. I can understand how one-sided that is. FT members don't know me, and yeah, I did kinda jump in with both feet. My bad. I accept your admonition.

4) About the second quote: I think that our posts crossed-up in the time-warp between when I get to write, and when I get to post, and read again. It turns out that the comment you are questioning was in post #15 dated Feb. 26th, and was specifically critical of certain web articles which denounce 'wild birds role in spread of H5N1', as a continuation of post #3. I think that I had composed post #15 off-line before I got to read where you mentioned GAINS in post #12. I write in odd moments, and then cut and paste into the forum. Forgive me please, I will try to read the intervening posts to see whether any of my comments could be construed to apply.

5) About GAINS: Thank you for bringing attention to GAINS (in post#12). I responded specifically to that reference in post #21 dated Feb. 27th where I commented briefly, but favorably on their web presence, and included a quote of the opening paragraph from their homepage. I had said... "From what I saw, their approach is both centric and bias-free". I don't know how those two separate posts got crossed, in your mind, but I'm glad for the opportunity to correct the misunderstanding.

6) I would like to propose that if something like this happens in the future, you can PM me. That way we don't waste readers time wading through my fledgling attempts to communicate clearly, and yet I will still be made aware if my posts are perceived other than how I intended.

Thanks again, ///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

Thanks very much to whomever (a moderator) changed the thread title from "Re: How to Think Analytically", to the new title, " Critical Thinking Skills Assist Sound Decision Making". It's really cool that you can do that in mid-stream, :cool: and even cooler that you did. Thanks. :D

I had some problems in posts #13 & 14 with links that didn't work.:confused: One did, so it apparently wasn't the use of the 'advanced' editor vs the 'std.' editor. To back-fix the situation, since I couldn't edit them anymore, please accept my providing 'replacement' links now.
post #13;
http://en.wikipedia.org/wiki/Critical_thinking

post #14;
http://www.wwfpak.org/150208_avian_influenza.php
WWF.org
http://www.worldwildlife.org/
BirdLife.org
http://www.birdlife.org/news/news/2006/05/avian_flu.html
http://www.aiweb.info/
http://www.aiweb.info/document.aspx?DocID=296
http://www.fao.org/docs/eims/upload/191072/EW_HPAIwildbird_aug05.pdf

Thanks to all, ///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

A couple of posts ago, Canagica had proposed a literature review on the topic of technical aspects and methods of field-testing for HPAI..... Here's some stuff I found,
( I know Canagica knows how to search, and I much enjoy reading his posts here at FT). For any who are not so versed, I will add.....
Any search depends on variables such as; entry point, search term(s), and branching paths as one reference vectors to the next. I will list only a few sources of info., since that is what he had asked about, but mostly I was surprised at how much is 'out there'. I exercised four 'entry points'. 1) search within Flutrackers general area, 2) Flutrackers 'Scientific Library', 3) a Google search, which listed (one of my favorites, Wikipedia) highly, and 4) go direct to a 'trusted source' (the CDC). Note: the stuff 'Quoted' are short snippets of the full text available if you follow the links...

My entry points:
1) within Ft......
http://www.flutrackers.com/forum/showthread.php?t=16284
According to the OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals (see References), considerations for sample collection for avian influenza in birds include the following:

* <LI class=body>Samples taken from dead birds should include intestinal contents (feces) or cloacal swabs and oropharyngeal swabs. Samples from trachea, lungs, air sacs, intestine, spleen, kidney, brain, liver, and heart may also be collected and processed either separately or as a pool. <LI class=body>Samples from live birds should include both tracheal and cloacal swabs, although the latter are most likely to yield virus. Because small, delicate birds may be harmed by swabbing, the collection of fresh feces may serve as an adequate alternative. To optimize the chances of virus isolation, it is recommended that at least 1 gm of feces be processed either as feces or coating the swab. <LI class=body>The samples should be placed in isotonic phosphate buffered saline (PBS), pH 7.0 to 7.4, containing antibiotics.


Once specimens have been collected and processed, the OIE Manual recommends the following for identification of avian influenza (see References: OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals):

* <LI class=body>The preferred method of growing avian influenza A viruses is by the inoculation of embryonated specific pathogen free (SPF) fowl eggs, or specific antibody negative (SAN) eggs of 9 to 11 days' incubation.


Serologic Tests

Because sera from infected chickens can yield positive antibody tests as early as 3 to 4 days after the first signs of disease appear, serologic tests can be useful to diagnose the disease. Examples of serologic tests are outlined below (see References: OIE: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals).

* <LI class=body>AGID
o <LI class=body>These tests have been widely and routinely used to detect specific antibodies in chicken and turkey flocks as an indication of infection. <LI class=body>They have generally employed nucleocapsid-enriched preparations made from the chorioallantoic membranes of embryonated fowl eggs that have been infected at 10 days of age,
Developing Techniques for the Diagnosis

In addition to the tests mentioned above, new diagnostics have become available in recent years, including:

* <LI class=body>Antigen detection tests
o <LI class=body>The commercially available Directigen Flu A Kit (Becton Dickinson Microbiology Systems), which is an antigen-capture enzyme immunoassay system, has been used for detecting the presence of influenza A viruses in poultry, particularly in the United States. The kit uses a monoclonal antibody against the nucleoprotein and should therefore be able to detect any influenza A virus. <LI class=body>The main advantage of the test is that it can demonstrate the presence of avian influenza within 15 minutes.
o The disadvantages are that it may lack sensitivity, it has not been validated for different species of birds, subtype identification is not achieved, and the kits are expensive.


2) also see Ft's "Scientific Library" at http://www.flutrackers.com/forum/forumdisplay.php?f=585

3) outside FT Googled [Zoonosis]
Wikipedia Zoonosis link at bottom ( Publications in Zoonotics and Wildlife Disease ) to.....
http://digitalcommons.unl.edu/icwdmother/21/
http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1020&context=icwdmother
I particularly like Wikipedia because of the great job they do with their citations, and also because often the references are even broken into sub-groups depending on their credibility or likely biases. Very helpful.

4) http://www.cdc.gov/eid/content/14/3/487.htm
All of the virus strains from domestic poultry used in this study were isolated by the Korean National Veterinary Research and Quarantine Service (NVRQS) in embryonated eggs that were inoculated with tissues and swab specimens collected from the oropharynx and cloaca of affected birds. Two subtype H5N1 strains were isolated in embryonated eggs that had been inoculated with fecal specimens obtained from migratory bird habitats by Chungbuk National University and Chungnam National University. Viral genes were sequenced and analyzed as described (9). The full-length sequences for each segment were used in phylogenetic analyses. Gene sequences determined in this study have been deposited in GenBank under accession nos. EU233675-EU233746.
and to the culling of flocks on reverse transcription-PCR confirmation (usually within 1 day) to prevent the spread of the disease.
During our routine survey for influenza activity in migratory bird habitats, on December 21, 2006, 2 distinct subtype H5N1 strains were isolated from fecal samples from 2 migratory bird habitats-one near the first outbreak farm in Chungcheongnam-Do, and the other from a stream in Chungcheongbuk-Do (Figure 1).
Our phylogenetic analysis of the hemagglutinin (HA) genes of all Korean isolates showed that the isolates belong to the A/bar-headed goose/QH/65/2005 (QH/2005)-like lineage that caused an outbreak among wild birds at Qinghai Lake in China during 2005, rather than the first HPAI (H5N1) lineage (A/chicken/Korea/ES/2003) that infected farms in Korea in 2003 (Figure 2). Notably, the 2 isolates from migratory bird habitats were closely related to the H5N1 subtype poultry virus strains:

From the old addage that "If you give a man a fish, you feed him for a day, teach him how to fish and you feed him for life", :) I would add....
This is a small review, but for anyone interested, 'go fish' and let us know what you find. :magnify:
Especially if it sheds light on the issue of making sound decisions about prepping for probable pandemic flu. Oh, and don't forget to watch the dates of publication, since so much is being learned about this developing science every month.
Happy fishing, ///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

A couple of posts ago, Canagica had proposed a literature review on the topic of technical aspects and methods of field-testing for HPAI..... Here's some stuff I found,
( I know Canagica knows how to search, and I much enjoy reading his posts here at FT). For any who are not so versed, I will add.....
Any search depends on variables such as; entry point, search term(s), and branching paths as one reference vectors to the next. I will list only a few sources of info., since that is what he had asked about, but mostly I was surprised at how much is 'out there'.

Thanks for the shout out, ///read///. I think I might not have expressed myself clearly, however; the thing that I'm interested in are tests of the tests, so to speak. I want to see a group of studies that take varied groups of wild, infected birds, and tests them using a series of protocols and tests, then compares the results. I have read for months about the low sensitivity of the tests used by various organizations, but I have yet to see a study about it (and, admittedly, I do have a day job and I may have missed it :))

There's probably some good reasons why this hasn't been done-the logistics of working in a BSL 3 facility are daunting, and there really isn't much money in it compared to the poultry/human side of testing. But a series of studies that investigated these themes would be very helpful in interpreting the data that are collected. The closest I've seen is a 2007 study from Germany that developed an assay to specifically test for Qinghai-like HPAI H5N1; surprisingly, this is how they describe the status quo with testing:
...many of the wild-bird samples that still yield positive results with the widely used and highly sensitive rRT-PCR test systems.
(emphasis added)

They then go on to test their new method against known samples, concluding that their new test is highly specific and highly sensitive:

...is also more suitable than a recently reported universal rRT-PCR system for discriminating between highly pathogenic H5 influenza viruses and those of low pathogenicity by use of SYBR green binding and melting point analysis (6). Finally, the system presented here was successfully operated during the 2006 German H5N1 outbreak in wild birds, and it is part of routine diagnostics of the German OIE and National Reference Laboratory for Avian Influenza.

But it still isn't an experiment with proper controls that would allow us to understand the role of the type of test/sample in interpreting the data it collects. The media has been quick to indict the testing as well, sometimes drawing flak from the testing organizations like this letter to the editor in New Scientist that followed on the heels of an article that suggested the tests being used by British authorities were the wrong ones:

There is no evidence of any difference between the sensitivity of the methods used by the Veterinary Laboratories Agency and those used in the study quoted that would explain the difference in the apparent crude prevalences in the UK compared with Sweden and the Netherlands combined. One does not expect a similar prevalence or presence of infection in all countries, nor a constant presence or prevalence of infection over time, as Ab Osterhaus, who led the study you quote, has indicated.

As a caveat, I find it easy to believe that there is variability in the performance of a test designed for domestic poultry when it is used on wild birds for which it wasn't designed. I just want the numbers! :magnify:

Until there is some science behind assertions about testing efficacy it seems a lot like handwaving.
 
Re: Critical Thinking Skills Assist Sound Decision Making

Why we shouldn't dismiss 'spread by wild birds'.
'Critical Thinking' skill for today is: Analysis of cause and effect.

Observing the temporal relationships of events is often a useful tool to establish 'cause and effect', but is the event we see happening first actually the cause? There may be ways that this logic is flawed. Often, flaws are in the assumptions we make without even knowing it. Do we assume that H5N1 would show up as quickly in wild birds as in poultry?

Given the huge numbers of wild birds, and the limited lifespan of most species, it is surprising that we don't see more dead birds around. The efficiency of predators, and scavenger animals, and the large expanse of 'open space' that exists on the earth's surface, calmly and silently absorb the annual attrition of large numbers of dead wild birds. In stark contrast, poultry on farms and in backyard flocks are 'watched like a hawk' (please excuse the natural analogy). Every dead poultry is carefully accounted for since it directly affects the farmers profitability or diet. Where bio-security is practiced, excess mortality due to any cause, and H5N1 infection specifically, are "reportable incidents" to the argricultural organizations. No such requirements for wild birds. Additionally, HPAI (H5N1) may be less visible in wild birds simply because the same virus, infecting both a wild bird and a poultry bird has a very different effect. Very rarely do the wild birds get sick or die, but often the virus is quickly lethal to the poultry.


Since wild birds tend to die 'silently' and domestic birds (poultry) are closely watched for 'excess mortality', there may be an in-built bias to observations about the sequence of events surrounding H5N1 outbreaks.
If poultry and wild birds are both actually dying in an area (the same area), there are only four sequences possible.
a) the wild birds started dying first,
b) both started dying at the same time,
c) the poultry started dying first.
d) The two events are not related, and sequence-in-time is irrelevant.

Since wild bird deaths may be missed entirely, or missed for a while, but the poultry deaths are noticed immediately, it will often seem that the poultry started dying first.

So, if the disease is spread to an area by poultry, then of course we would expect to observe poultry deaths first. If the disease is spread to an area by wild birds, it may still 'show up' in poultry first. Even against this skewed bias, there are instances where it has been observed in the wild birds first, or as in this recent report, seen in wild birds, but not in poultry. http://www.flutrackers.com/forum/showthread.php?t=56170

"The bird carcass was found and collected on February 29 near the management centre in Tai Po Kau Nature Reserve.
Oriental Magpie Robin is a common resident bird in Hong Kong.

"In view of this case, we have conducted a thorough cleansing operation in the nearby area of the management centre today. Notices have been put up near the management centre to remind the public to avoid contact with birds and their droppings. Our country park staff will also step up precautionary measures in the parks," the spokesman said.

The spokesman said there was one commercial chicken farm within three kilometers of where the bird was found.
The AFCD had immediately sent staff to inspect the chicken farm, and had found no abnormal mortality or symptoms of avian influenza among the chicken flocks. "

Also, there are many types of wild birds that can each carry H5N1, and each species reacts differently to it. The species that brings the pathogen to an area may not succumb to it at all, and the species of wild birds that show mortality may be 'the victim' as much as the poultry. There would be a slight delay due to both transmission and incubation period. However, this could take much longer in the 'socially-distanced' natural environment, than it would in a crowded poultry barn. Additionally, poultry have been shown to react rather uniformly to H5N1 infection, by dying, rather quickly (often within 24 hours of infection), in contrast to the wild birds, many of which survive the infection.

Even where poultry are not free to roam outdoors, it is not difficult to envision that very few wild birds need to be actively shedding virus at any given time, to have a profound negative effect, when you consider that 1 gram of fecal material can carry enough virus to infect 1 million birds (see References: APHIS: Highly pathogenic avian influenza)
http://www.aphis.usda.gov/publications/animal_health/content/printable_version/USA_AvianInFluenzanewweb.pdf
That statistic alone is sobering, and should admonish all to not discount or dismiss any possible disease vectors, since
people involved in feeding and removing manure from bio-secure poultry operations can easily transmit infected material from outdoors to indoors, and non-biosecure poultry are literally 'sitting ducks'.

Thanks to all, ///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

Canagica,
I understood your interest, and apologize for not addressing it more directly. You were plenty clear, I just couldn't tackle it all in one post. ( I agree, day jobs are the pits). I'm new to this term shout-out, had to look it up. Wikipedia says:
"A shout-out is a greeting or acknowledgment of a person, group, or organization of significance. It is often done as a sign of respect, synonymous with "giving props". "
as in "proper respect". Absolutely right! I highly respect everyone who takes time to contribute to FT. I have learned a ton from reading here and it's because of good questions just as much as answers.
First, I may not be able to add much value to the question of 'testing the test methods'. That depends on whether the information is out there. The way it looks to me is that all methods are equally ineffective (on live, wild birds) , so the answer you seek may be that it's not the fault of the tests, the testers or the interpretation. The possible reality is that the AI viruses and wild birds are so well adapted to each other that it is virtually undetectable until it 'switches-on' and causes death. I agree with your question, and would also like to know the answer, even if just for curiosity. I would add a question ( or three). In light of the thousands of tests that aren't finding H5N1 in live wild birds, why do they keep doing them? Is it a feel-good exercise that provides the 'masses' with comfort that they aren't under attack from aerial bombardment with infected feces? Would that cause panic?
I took a step at finding info. on what types of tests are common, and HOW they are done, and used that step as a springboard to scratch the surface of 'digging' for data. More to come on websearches later.
Since my thread is more about 'critical thinking' than any topic in particular, the value that I see in this question is that it leads us to greater understanding of the; issues, motivations, communication, and validity of the opposing arguments. The deeper the question takes us, the more insight we can acquire. The steep side of the learning curve has more questions, and the easy side has more answers. Both are fun. Let's keep looking.....
Thanks to all, ///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

Thank you ///read///,
it was good to insert analyse questions in the posts, and not only mere news text replicas. The problem will be how to extrapolate an ultimate result with so much unknown variables.
Because the scientist did not released an final answer, the lay reader will assumed the answer by plain deductions (no matter if it is scientificaly exact).

An example from few excerpts of the post text:

1. "Very rarely do the wild birds get sick or die, but often the virus is quickly lethal to the poultry."
2. "In light of the thousands of tests that aren't finding H5N1 in live wild birds, why do they keep doing them?"
3. "Is it a feel-good exercise that provides the 'masses' with comfort that they aren't under attack from aerial bombardment with infected feces? Would that cause panic?"

Now, from the above, without certain "ultimate study results", with no matter if the result will be scientificaly exact, I, and probably the vast majority of the web readers, would deduced and profile the behaviour like this:

1. a) If very rarely do the wild birds get sick or die, that means the illness is not an very lethal one for them in their natural environment
b) The a), does not exclude that the birds are the species which spread the virus to the poultry, but they are enaugh robust to prevail it, or
c) They are not so much robust, but the spreadings between wild birds are of much smaller entity than for the poultry for reasons of mass poultry caging

2. After thousands of tests that aren't findinding H5N1 in live wild birds, they keep doing them because:
a) They think that if the illness is mainly spreading through wild birds, they must found more infected wild birds even with low sensitive tests, because the illness is so lethal, and if it not (because of the robustness of the species), it can't be that such a big number of wild birds can be asimptomatic spreaders without evidenced it in the tests
b) They think that between so much wild birds who change place every moment, they cannot be sure that they did not missed the infected ones, and they continue to testing to find them
c) They do them because something must be done even if doubtfully, to try to tracking the illness if it is spreading from wild birds

3. Yes, of course. It can be reasonable that they insist to exercise the tests, because, in lack of scientific ultimate proves, that provides the 'masses' with comfort that they aren't under attack from aerial bombardment with infected feces.

Never dismiss the simple mind thinking, it drived the moust of the "mass thinking" behaviour without other certainity statements.

"Would that cause panic?"
You can bet on! :D
 
Re: Critical Thinking Skills Assist Sound Decision Making

First, observations.

Complex problems cannot be solved by specialists, nor collaborating groups of specialists. They are too narrow in their reading and knowledge base (the so-called 'forest and trees' effect), failing to catch the significance of many published findings in other fields that afford direct or indirect insight into process mechanics. Resolving minutia within a 'layer' of nested cause and effect is largely ineffective because it fails to address inter-layer connections between orthogonal sets of cause and effect.

The solution set to a complex problem space is an orthogonal projection. Related problems usually have related solutions in broadly overlapping spaces and projections. Because problems and their solutions reside in a physical environment defined by thermodynamic laws (at least at the gross material and molecular levels), there exists a matrix of physicochemical 'connectedness' that must be explored, tested, and inter-related networked factors elucidated, to untangle and simplify complexity (knots) within large, long-standing problems.

Like infectious disease.

Short answers to some of the questions posted here:

If wild birds are the hosts of these viruses, why aren't we finding them more often?

Who said we are not finding them? Questions of testing method efficacy aside, the answer is that these viruses infect their hosts for a defined period of time, very short-lived under most circumstances.

Problem 1: not looking in the right places.
Problem 2: not looking at the right birds.
Problem 3: not looking at the right time.

If you shoot in the dark or use a blindfold, you will miss a nearby target 99 out of 100 times.

Truth 1: aquatic fowl carry avian influenza viruses - sometimes several, but only under specific environmental conditions.
Truth 2: aquatic fowl are only exposed and become infected and reinfected under specific physiological conditions.
Truth 3: the knowledge base of science specific to migrating water fowl is surprisingly sparse, despite continuous funding by many public and private granting institutions of avian physiologists and ecologists, for many decades.

The larger problem? Failure to connect need in one area with research efforts defined by programmatic funding goals in what might appear to be an unrelated area.

In order to solve the enigmatic question of how a low pathogenic virus carried by avians without harm for tens of thousands of years (probably MUCH longer) suddenly becomes virulent and lethal to it's hosts or how and why it can rapidly adapt to new hosts, you must *significantly* broaden your knowledge base.

The truth will set you free.
 
Re: Critical Thinking Skills Assist Sound Decision Making

Hi Tropical. Thanks for reading, and for a thoughtful post which has its "finger on the pulse' of the issue. I am glad you enjoy the analysis thread. In an effort to assure that I am responding to what you intend, I am going to paraphrase you're text in a couple of places. If I have missed the point, please steer me back on course.

The problem will be how to extrapolate an ultimate result with so much unknown variables.
Because the scientist did not released an final answer, the lay reader will assumed the answer by plain deductions (no matter if it is scientificaly exact).

I agree with you 100%. When 'the experts' are either; unclear, or provide conflicting data, or reach conflicting conclusions, the non-experts are confused. Not by any fault on their part, but by the definition of the word 'confused'. That is precisely why I started this thread, to try to provide 'thinking tools' and some examples, that average people can apply, when they need to make decisions based on 'messy' data. I think that many people read FluTrackers (FT) for the same reasons, they want answers (and in an absence of "scientific final answer" will make "plain deductions") to;
1) Is there going to be a pandemic?
2) When will it happen?
3) How bad will it be?
4) How long will it last?
5) What can I do about it?
6) When should I start?
7) How much time and effort should I expend?
8) How do I rationalize prepping to my; mate, family, friends...?
9) Should I 'keep it private', or become active in my community?

Because so many people probably have the same thoughts, I will say (you), but understand that I mean (everybody) that agrees with the concept in this list. I am not an expert on; bird flu, infectious diseases in general, or pandemic preparedness. I am a self-taught 'critical thinker', who has found a method to make sense of confusing data,that works for me, and would like to share that method.

Right away, we can break this list in half. One of the 'thinking tools' is to guess at answers, and see where that takes us. It sounds silly, but let's just try it. Starting with number 5) . If we were to guess at an answer such as NOTHING, what effect would that have on the other questions? They all become irrelevant huh? So we are really happy that we can do something about it. What can we do? There are two kinds of things; some are general and some are specific.

General:
A) Adopt an attitude that a pandemic disease is 'the enemy', and we are going to learn as much as we can about 'the enemy' so that we can keep it from killing us. (put Sun Tzu's "Art of War" on your 'during pandemic' reading list).
B) Recognize that any talk of stopping the pandemic from happening is making a rather large assumption, that we can. We probably won't be able to. That thought alone is difficult for some people in today's technology-advanced society to grasp, but we need to get it out on the table. Some things are just plain BIGGER than us. It doesn't mean that people shouldn't be trying to make vaccines, and new anti-viral drugs, etc. It just means that they should also have a plan 'B', which includes prepping.
C) Organisms of all types operate on 'stimulus - response' and those with higher-order thinking capability also operate on 'risk-reward'. Questions 1-4 (and their answers) comprise the 'stimulus', and our task is to identify and implement a measured and appropriate 'response'. Questions 6-9 are more in the 'risk - reward' category.
D) Avoid 'paralysis by analysis' thinking that hinges on " if I don't know the exact answer then I can't do anything at all". A good antidote is to break the 'elephant' into smaller pieces, and then respond to each one separately.
E) Recognize that 'starting' to take action is only the first threshold to overcome. Each incremental step in preparing is itself another, smaller threshold. Create a list that pairs 'threat level' with 'response action'. If the current 'threat level' is already at or above the 'response action' tasks that you have accomplished, then this list is also an action plan.

Specific:
A) You don't even have to list what is really important in an emergency, because Flutrackers already has a wealth of information on; water, food, vitamins, herbs, masks etc. Make the list anyway. There is something rather personal about thinking about what you (and your loved ones) need to stay alive for various periods of time. What do you need for the next 15 minutes, the next 8 hours, the next day, the next 12 weeks. Reading about it is too detached, too remote, too easy to put it off or dismiss it completely. Write it down. Make it detailed. If you get writer's block, see B)....
B) Make two lists. As you go through each day, write down everything you touch, eat, drink, breathe, or depend on for your daily existence (once is enough for each item). If it's not needed for survival, and in a pandemic you could just 'cross it off', then it goes in the 'B' list. If you need it now, or don't need it now , but would in a pandemic, it goes on list A).
This exercise alone may just revolutionize your life. It's a 'what's really important' thing. Doing this takes 'preparing' out of the abstract and theoretical world and gives it some teeth.

Now let's get back to 'how much' and 'when', and create our 'ladder of thresholds' for measured and appropriate responses to various stimuli. A second 'thinking tool' is to use the best answer we have today, and then ask what we should do based on that. It's like U.S. President Eisenhower said, "Plans are invariably worthless, yet planning is indispensable". If we get a better answer tomorrow, then we can change the plan to reflect that, but we shouldn't not act in the meanwhile. Or as General George S. Patton said "A good plan today is better than a perfect plan tomorrow." So let's see what those same questions look like with today's (imperfect) answers.

1) Is there going to be a pandemic?
Yes. This is something that all of the experts agree on, so this is a simple answer. It may not be H5N1, It may not even be some other Avian Influenza. It may not be this year, or next, but it will happen. There are so many emerging diseases, and re-emerging (drug resistant) diseases, that everyone should be assigning some portion of their time and energy to creating a buffer in case of disruptions in the super-efficient-yet-fragile infrastructure that supports the 'developed' world. Most things that you do to prep for a pandemic are great insulation from worry for natural disasters too.
2) When will it happen?
Sooner than we want. Sooner than almost anyone can be ready for, even if they already started. Talk to anyone who IS preparing, and they will tell you that 'there's always more that can be done', and 'it all takes longer than you want it to'. Also, if you are waiting for the WHO to declare Phase 4 of pandemic alert, anything you want will not be available, because everyone will want it then.
3) How bad will it be?
History tells us that eventually, there will be a devastating pandemic. Most scientists agree that H5N1 has the earmarkings of being that 'hugely severe' disease.
4) How long will it last?
When we are in it, it will seem like an eternity. Estimates of 'disease wave' duration say 2-3 waves of several weeks each, but that isn't what people should prepare for. They should recognize that any severe pandemic will (not might, or may) disrupt the world's; economic, transportation, healthcare and public safety infrastructures. The way to think about this is that every generation prior to our grandparent's, that could afford to, were more self-sufficient than we are today. Our generation is the anomaly, and we are complacent in our ignorance. I am speaking of the 'first world' nations here.
5) What can I do about it?
Preparing ( aka prepping); that deliberate and continuous process of creating and maintaining a store of knowledge, tools and rations that serve to insulate people from harm, when the fabric of society is weakened or diminished, either locally and temporarily, or more globally and permanently.
6) When should I start?
You already have. Everyone does some things, and has some knowledge, and has some reserve of skill and energy and resources to apply to overcome spells of misfortune. So all we are talking about is what constitutes the next steps in the ladder. Don't delay the next steps.
7) How much time and effort should I expend?
How much are you worth? It is like buying a motorcycle helmet. If you have a $5 head, then you can buy a $5 helmet. If you value your life more than that, where is your line? What percent of net income would create a significant increase in your self-sufficiency? Try spending that amount and then see how you feel. Are you more relaxed? Better peace of mind, and lower stress? Besides, a lot of prepping isn't about spending money. It's in planning, and organizing. What you spend on food in the long run may be about the same, or perhaps less, if you eat more meals at home instead of eating 'out'.
8) How do I rationalize prepping to my; mate, family, friends, ...?
Get them to read here at Flutrackers. "Rational minds, equally informed, seldom disagree", so the challenge is to expose them to the information. Consistent, low-key, non-inflammatory supply of data in ways that are relevant to their lives, over time, will sink in. If someone is irretrievably irrational about it, then they simply have to accept you as you are (with your concerns) equally to your acceptance of them (with their denial). Identify portions of the prepping effort and expense the same way that you rationalize insurance. You don't buy it because you expect to need it, you buy it hoping that you never will, but it still makes sense to do.
9) Should I 'keep it private', or become active in my community?
This a personal decision. My perspective on this is that even personal preparation has a beneficial impact on the community. Just as 'herd immunity' results when a significant percentage of a population is vaccinated, the people who don't prep are more likely to survive because those who do prep take pressure off the system, when the system is most highly stressed.

So, in my opinion, we shouldn't need [ certain "ultimate study results", with no matter if the result will be scientifically exact ] to make decisions to prepare. Perhaps, continued vigilance of the developing situation allows us to fine-tune our response. However, even "lay readers" like ourselves can figure out that this situation is threatening. Smart readers will take effective actions to insulate themselves from the impending harm. Just for fun, let's look at the details to see if they can help us fine-tune, or not.

Your excerpts from my post:
1. "Very rarely do the wild birds get sick or die, but often the virus is quickly lethal to the poultry."
2. "In light of the thousands of tests that aren't finding H5N1 in live wild birds, why do they keep doing them?"
3. "Is it a feel-good exercise that provides the 'masses' with comfort that they aren't under attack from aerial bombardment with infected feces? Would that cause panic?"

Statement # 1.) The 'context' of this statement is talking about the effect of H5N1 on wild birds vs the effect of H5N1 in poultry flocks. The first part is true of Avian Influenza (AI) in general, less so for H5N1, since it has caused numerous die-offs in wild birds. The second part is also true of AIs in general, in that wild birds are better adapted to influenzas. Infectious diseases that wild birds show no symptoms of are known to kill poultry. H5N1 has been tremendously lethal to poultry. Recent reports detailed chickens dying within 3 hours of first showing any symptoms.

Your Comments:
1. a) If very rarely do the wild birds get sick or die, that means the illness is not a very lethal one for them in their natural environment
b) That a), does not exclude that the birds are the species which spread the virus to the poultry, but they are enough robust to prevail it, or
c) They are not so much robust, but the spreadings between wild birds are of much smaller entity than for the poultry for reasons of mass poultry caging


1. a) Increasing our knowledge of what effects the disease has in other species is good. However, the definition of an emerging infectious disease suggests that we shouldn't put too much faith in forward-looking statements, based on past performance. Normal behavior for Avian Influenza is to infect wild bird intestines, in a mild, non-life-threatening way. A couple of serotypes; H5s and H7s have shown a tendency to change to a lethal form (from LPAI to HPAI). H5N1 has broken so many of the 'rules' (or things we thought we knew about AIs), that it's in a class by itself.
Even though "rarely do the wild birds get sick or die", H5N1 has been an exception, and caused huge wild bird die-offs, not only by infecting the gastrointestinal tract, but also infecting the respiratory tract, and has shown capability to infect many other organs in wild birds, whether in their natural environment or not, (like a zoo, or songbird cage). The word 'wild' refers to "not selectively-bred by man" rather than to where it lives. see http://www.flutrackers.com/forum/showthread.php?t=30016


Free-living birds in the orders Anseriformes (ducks? geese? swans) and Charadriiformes (gulls? terns? shore birds) have traditionally been considered the natural reservoirs for avian influenza viruses (AIVs).[1?2] However? before 2005? no evidence showed that highly pathogenic avian influenza (HPAI) viruses were maintained in wild bird populations.

b) That a), does not exclude that the birds are the species which spread the virus to the poultry, but they are enough robust to prevail it,
1. b) I agree. Just because AIs in general have rarely been lethal to wild birds, and H5N1 has been, doesn't mean it is always "very lethal" in them. It doesn't have to be just one or the other. It can be both. It can switch on/off. It can depend on; the bird species, the strain of H5N1, the environmental 'stressors' (such as weather and food availability), the viral load they are exposed to...etc. The likelihood of transmission is dependent on several factors such as; the viral reproductive rate (Ro), which organ(s) are infected, how the virus is excreted, the temperature, bird density... etc. It quickly becomes apparent that trying to predict any single event about the spread of this disease is nearly impossible since two situations that seem to be similar, may have vastly different results. It can appear to be dormant, and then rage again. Areas in which it is endemic are an even tougher problem, since there can be host species other than birds.

c) They are not so much robust, but the spreadings between wild birds are of much smaller entity than for the poultry for reasons of mass poultry caging

1. c) You're right, the disparities that we observe in mortality of wild birds vs poultry may not be caused by the wild bird's being (more robust) than poultry, but by the poultry's dense farming practices. In general, wild birds have more resistance to AI diseases than poultry. It has to do with the genetic effects of selective breeding of the poultry( and may have to do with today's chicken having descended from 'jungle fowl', not water birds). That doesn't mean that if someone were to cage a bunch of wild birds and infect them, that H5N1 would kill any fewer of them. H5N1 is writing its own 'playbook' as it goes, we get to watch it happen. Maybe 10 to 20 years from now someone can say with certainty that H5N1 does this (or it doesn't do that), but it is way too new, and changing too fast to say with certainty now. It's not the scientist's fault that they can't say with certainty. Scientists learn from nature, not the other way around.

Statement # 2.) About the 1,000s of tests that are done, and do not find the disease....

2. a) You bring up a possible relationship between; lethality, the showing of symptoms, the sensitivity of the testing, and transmissibility (infectiousness and spread) in the wild birds. It would be convenient if some relationship existed, and if we could figure it out, but there is no rule that says a relationship must exist. I only hope that they are keeping the 1,000s of samples in 'deep freeze' so that if better tests become available, they can fill in the database later.

2. b) I think you are referring to the statistical significance of their 'sample sizes' relative to the entire population of birds. I have read about the methods for trapping the birds, and how they try to be random about it, and get a true cross-section of the flocks. Besides, many tests are done on hunter-killed birds, which should be fairly random. I don't think that would be the reason for not finding the virus.

2. c) I think you're right on it! One of the 'thinking tools" that I use is to 'put myself in the situation'. If I were tasked with being vigilant, I would have difficulty saying that the tests should be stopped, only because we hadn't found it yet. I would try to use the best tools available, and hope that they became effective if-and-when the virus mutated to be an even greater threat.

3. Yes, of course. It can be reasonable that they insist to exercise the tests, because, in lack of scientific ultimate proves, that provides the 'masses' with comfort that they aren't under attack from aerial bombardment with infected feces.

Statement # 3.) We agree, but as comforting and assuring as the testing may be, I only hope that it is not false comfort. A little bit more 'panic' would get more people to prepare, and ultimately save human lives. The risk is that too much panic can cause harm too. I think I would not want the job of deciding when to raise the alert level (WHO). I do think that more could be done in a progressive, and gradual, but increasing intensity. Due to human nature, there is likely to be an overlap between the 'threshold' (.....o0|0o....) of incentive for some people to take effective action, and the 'trigger-level' (......o0 |snap! ) for other people to start to panic. IMHO the greatest number of people will survive due to their own preparedness, only if awareness and incentives are gradually and progressively increased such that ~5% of people are starting to panic just before TSHTF. Too much beforehand, and the 'collateral damage' is increased. The larger danger is in having not enough people preparing, for a couple of reasons; 1) things always take longer than anticipated, prepping especially 2) impossible to be 'fully prepared', there's always more to do 3) People are more resilient than the authorities give them credit for (most folks can deal with, and want, the truth).

Sorry it took me so long to respond......
///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

Hi ///read///, thanks for reading, and answering the post.
Sorry, I'm answering late, also.

For now I have not new elements for analyse other that the situation in China, that with other places (US, ...), mimicked the australian one last year. I agreed with you that we will not be able to stop an real pandemic to spread, and that our generation seems too confident that the technology will save us.

On the other side, the vast majority will not think about, nor will prepare itself, till their official bodies tell them that is starting.
That's another kind of prep, it's not a tornado, or something that can pass fast. We can only hope that it would pass another decade without a pandemic, like after the 1997. Beside, there are many other problems.

My best wishes.
 
Re: Critical Thinking Skills Assist Sound Decision Making

Hello, Oracle....
Your words paint an effective graphic of the difficulty of solving multi-dimensional problems by application of single-dimensional tools or skill-sets. I agree with that assessment. I differ with your statement ..... "nor collaborating groups of specialists." I think that is one of the ways to bring multi-dimensional problem-solving skills and abilities to bear on an issue. This forum is an example of a collaborative group of specialists (we are each a specialist in something, whether we recognize it or not) working on complex problems. Thank you for joining this group, and I highly value your input toward our common goal. You have laid the groundwork for one of the more advanced and powerful 'critical thinking' skills, that is called 'mental imagery'. Advanced because it requires the use of 'the mind's eye' and 'spatial relations', powerful because it enables visualization of solutions which don't exist in 'flat views'. Drawing from the description in your post, I get a mental picture of a possible 'solution space' as a counter-top populated with layer cakes, each one has a name. One might be Government, another might be Academia and so on. The vertical component is the organizational structure, and the lateral dimensions are the breadth and depth of knowledge in each of the many departments and divisions at each level in that organization. The synthesis of solutions to complex problems may require an omniscient perspective. Lacking that, generalists and groups of specialists, with the ability to , and interest in, processing and analyzing large amounts of data, may be able to get 'close enough'. Their efforts are often accelerated by structured effects such as technological advances in communication (the internet) and unstructured effects such as networking (six degrees of separation) and serendipity (chance). Please allow me to impose on that 'solution space' a multi-dimensional problem. It's appearance is that of an XYZ coordinate systems (Cartesian), and I will embellish that image by labeling the axes (with your permission). Let's say X is TIME. Y can be SPREAD DUE TO POULTRY, Z can be SPREAD DUE TO WILD BIRDS. I will propose that the goal is to create a graph that depicts a line both parallel and very close to the X axis. Restated, the goal is to watch time go bye, while not seeing significant spread caused by either poultry production or by wild birds. By spread, I would include aspects such as; geographic proliferation, genetic diversity, expanded count of disease-host (reservoir) species, expanded count of disease-affected species, and gross numbers of individuals affected within each of those species. Obviously, the concept of a disease 'host' or 'reservoir' species that does not reach an evolutionary 'dead end' is itself another axis in the 'complex analysis space'. My contention in 'weighing-in' on the wild birds vs poultry debate is that either mechanism (independent of the other) is sufficiently viable to maintain a threat to the human population. Therefore, people would be well advised to prepare themselves to Shelter-In-Place for months. If someone wanted to solve either or both of these problems, they might search the available literature with preference toward the intersection of epidemiological and ornithological or agricultural studies. I do, and I don't. I do use those studies and the controversial debate that ensues, for examples to share 'critical thinking' skills. I don't, in that I harbor no false hopes that either or both are solvable. My argument (meant in the most civil and philosophical sense) is that unless we, meaning all people, can address and solve both the wild-bird natural reservoir AND the poultry production chain of flare-ups, then we are collectively laying on the 'train tracks', and it's only a matter of time before we get run over. My further argument is that the situation has already progressed beyond the point where answering the 'spread' question will have any bearing at all. My argument is that H5N1 is 'out there', and now 'will not be denied'. My position is that Pandora's box is irretrievably open, and the best we can do is to gird ourselves for the onslaught. I have posed my discussion of the responsibility of 'wild birds vs poultry' in the spread of H5N1 as the real issue or 'problem' that we need to solve. That is only because my perception was that a significant number of people are not preparing because they think that the problem can be solved by regulation of the poultry trade (legal and illegal trade). They think that 'someone else' will find a solution, and then the problem will fade away. The MainStreamMedia (MSM) roller-coaster is mostly on a low ebb right now and that only reinforces the public perception that pandemic flu WAS a threat, not IS. What I see as the actual problem is the broad public perception that something CAN be done about it, and will be done about it. That is the assumption that needs to be challenged. People have a strong tendency to 'take the easy way out'. It is easy to adopt an 'attitude of entitlement' which places the responsibility on the government. It is a more rare virtue to take personal responsibility. The real problem is not whether the spread is due to wild birds or poultry, it is in finding a way to get people to prepare for an event that is inevitable yet unpredictable, horrific yet capricious. Returning to the 3-dimensional graph from above, let's visualize what has happened over the past 5 years. The graph has taken off into Y-Z space in a ragged shape, yet following some dually exponential function with respect to the 'time' axis. In spite of massive efforts to contain the spread, and control the impact of H5N1, the situation is worse now than at any previous time, and is accelerating. Each person, who is not in denial of these implications, should have a clear boundary (a pair of orthogonal planes perhaps) established which serves as an 'alarm' level. The extent beyond which they are no longer comfortable, and that triggers a change in their behavior. Anyone who has not defined such a criteria is fooling them self. Each person's boundary will be different, for various reasons, and so people will reach their 'tipping points' in dribbles and waves, if the stimulus is progressively increased. This is the desirable situation NOW, before the WHO raises their alert level to 4 (we are currently at 3). There is too much already tied to that trigger. Anyone who is waiting for that as their signal is likely to be left out in the cold, because so many people are waiting for that. In fact, there is a dammed-up pressure on governmental agencies to not raise the WHO alert level because it is likely to trigger a cascade of events that would be significantly damaging all on its own. We entered this Pandemic Flu situation with the alert level at 3, back in 2003, and it is likely that it won't go to 4 until it's too late, then it will probably jump rapidly to 6, a phenomenon known as 'scale compression'. The 'scale' then becomes a 'switch'. It's off or it's on. From don't worry, to worry a lot. From 'do nothing' to panic. My intent is to provide people with some 'critical thinking' tools and guidance (by examples), so that they will recognize that their tipping point (their own personal alarm level) needs to be on the near side of any event that would cause the WHO alert level to go to 4. Let anyone reading this just close their eyes for a moment, and visualize (another thinking tool) what that event would be. Yes, now, before you read any further. How many said "it's already happened"? excellent! How many said "when the MSM tells me to"? How many said "when the CDC confirms a cluster of more than (xx) number of people"? How many said "the next time it spreads to another continent"? Anyone who said 'yes' to one or more of the last three questions needs to ask themselves..... is that what the WHO is waiting for too? If so, then too late! So, is the real question even about the science of epidemiology and spread mechanisms, or is it about what we call 'human nature', social engineering, and 'tipping points'? For those hung up on the science aspect, consider that the wild birds and poultry threats combined, and in their current demonstration of 'feeding on each other', may not be separable issues, nor solvable issues. The U.S. government, much to their credit, have recognized this, and wisely have decided to push the RESPONSibility down to the lowest levels, via state governments to the local (county) and community level. This is appropriate and helpful, because it forces the local infrastructure to think and act. That local preparation is very important, since that is where the needs will arise, and that is where the needs will, or won't, be met. In a climate of social distancing, and reduction of geographic disease spread, the concept of interstate transportation of; federal staff, equipment, and supplies, to solve a local problem is illogical. People and communities need to become self-sufficient. Now. Did I say NOW? Yes, OK, time to get off the soap box.

Thanks again to Oracle for the 'complex problem space' commentary, and insightful framing of the scientific, and organizational difficulties that have not yet been solved. I'm off to do some more prepping.....

Thanks to all at Flutrackers, and Happy St. Patrick's Day 2008, ///Read///
 
Re: Critical Thinking Skills Assist Sound Decision Making

First, let's separate out issues.

1a. Resolving cause and effect behind HPAI outbreaks and propagation within avians. 1b. Preventive action to reduce the odds of HPAI outbreak.

2. Planning and preparation in anticipation of the next influenza pandemic, with respect to tacit recognition of a long history of episodic outbreak, and HPAI transmission to and within mammal populations.

I fully agree that the second is exceptionally important and should be attended to as a priority collective action of risk-control.

As to the first, I caution patience and adoption of a positive, 'can-do' attitude.
 
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Re: Critical Thinking Skills Assist Sound Decision Making

Even though I have been using the "spread by wild birds vs poultry" topic as a springboard for discussion of techniques used in "critical thinking", I also feel committed to the topic itself. Actually, persistence in finding relevant data, and a continued openness to new information are both attributes of 'critical thinking'. This article just came to light....

Thanks to GSGS in this thread.... http://www.flutrackers.com/forum/showthread.php?t=60729 for posting a link to...
http://www.cdc.gov/eid/content/14/4/600.htm?s_cid=eid600_e
Wild Ducks as Long-Distance Vectors of Highly Pathogenic Avian Influenza Virus (H5N1)
Volume 14, Number 4?April 2008

Abstract:
Wild birds have been implicated in the expansion of highly pathogenic avian influenza virus (H5N1) outbreaks across Asia, the Middle East, Europe, and Africa (in addition to traditional transmission by infected poultry, contaminated equipment, and people). Such a role would require wild birds to excrete virus in the absence of debilitating disease. By experimentally infecting wild ducks, we found that tufted ducks, Eurasian pochards, and mallards excreted significantly more virus than common teals, Eurasian wigeons, and gadwalls; yet only tufted ducks and, to a lesser degree, pochards became ill or died. These findings suggest that some wild duck species, particularly mallards, can potentially be long-distance vectors of highly pathogenic avian influenza virus (H5N1) and that others, particularly tufted ducks, are more likely to act as sentinels.

Excerpt:
To test the hypothesis that wild waterbirds can excrete HPAIV (H5N1) in the absence of debilitating disease and so potentially act as long-distance virus vectors, we experimentally infected 6 species of wild ducks with an avian isolate of HPAIV (H5N1) from Europe, obtained in 2005 (A/turkey/Turkey/1/2005). We chose ducks because they are an important group in the epidemiology of avian influenza in the wild, although other waterbird species, such as geese, swans, and gulls, also play a role (15). We chose these particular duck species because of their abundance, preference for freshwater habitats, and migratory pattern spanning Asia, Europe, and Africa (Table; Appendix Figure 1). All 6 species are listed by the European Union as carrying a higher risk for avian influenza (18).

Also of note in this article, is the depth and clarity of explanation into the test methods that they used. Canagica may just be delighted with the back-to-back comparison of 1) virus isolation and 2) RT-PCR, including graphs and microscopy slides. :)
The assumption is that those two methods are the most effective for wild bird testing. Why do such an exhaustive study with anything less?

Thanks to all, ///Read///
 
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