tetano
Editor, Senior Moderator
Crit Care Med
. 2020 May 26.
doi: 10.1097/CCM.0000000000004457. Online ahead of print.
ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019
Sara C Auld, Mark Caridi-Scheible[SUP] 1 2 [/SUP], James M Blum[SUP] 1 2 3 4 [/SUP], Chad Robichaux[SUP] 3 4 [/SUP], Colleen Kraft[SUP] 5 6 [/SUP], Jesse T Jacob[SUP] 7 5 [/SUP], Craig S Jabaley[SUP] 1 2 [/SUP], David Carpenter[SUP] 1 [/SUP], Roberta Kaplow[SUP] 8 [/SUP], Alfonso C Hernandez-Romieu[SUP] 5 [/SUP], Max W Adelman[SUP] 5 [/SUP], Greg S Martin[SUP] 1 9 4 [/SUP], Craig M Coopersmith[SUP] 1 10 [/SUP], David J Murphy[SUP] 1 9 11 [/SUP], Emory COVID-19 Quality and Clinical Research Collaborative
Affiliations
Abstract
Objectives: To determine mortality rates among adults with critical illness from coronavirus disease 2019.
Design: Observational cohort study of patients admitted from March 6, 2020, to April 17, 2020.
Setting: Six coronavirus disease 2019 designated ICUs at three hospitals within an academic health center network in Atlanta, Georgia, United States.
Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period.
Interventions: None.
Measurements and main results: Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower PaO2/FIO2 ratio, higher D-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy.
Conclusions: Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness.
. 2020 May 26.
doi: 10.1097/CCM.0000000000004457. Online ahead of print.
ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019
Sara C Auld, Mark Caridi-Scheible[SUP] 1 2 [/SUP], James M Blum[SUP] 1 2 3 4 [/SUP], Chad Robichaux[SUP] 3 4 [/SUP], Colleen Kraft[SUP] 5 6 [/SUP], Jesse T Jacob[SUP] 7 5 [/SUP], Craig S Jabaley[SUP] 1 2 [/SUP], David Carpenter[SUP] 1 [/SUP], Roberta Kaplow[SUP] 8 [/SUP], Alfonso C Hernandez-Romieu[SUP] 5 [/SUP], Max W Adelman[SUP] 5 [/SUP], Greg S Martin[SUP] 1 9 4 [/SUP], Craig M Coopersmith[SUP] 1 10 [/SUP], David J Murphy[SUP] 1 9 11 [/SUP], Emory COVID-19 Quality and Clinical Research Collaborative
Affiliations
- PMID: 32452888
- DOI: 10.1097/CCM.0000000000004457
Abstract
Objectives: To determine mortality rates among adults with critical illness from coronavirus disease 2019.
Design: Observational cohort study of patients admitted from March 6, 2020, to April 17, 2020.
Setting: Six coronavirus disease 2019 designated ICUs at three hospitals within an academic health center network in Atlanta, Georgia, United States.
Patients: Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period.
Interventions: None.
Measurements and main results: Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower PaO2/FIO2 ratio, higher D-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy.
Conclusions: Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness.