tetano
Editor, Senior Moderator
Crit Care Explor
. 2021 Jul 16;3(7):e0494.
doi: 10.1097/CCE.0000000000000494. eCollection 2021 Jul.
Six-Month Pulmonary Function After Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019 Patients
Amédée Ego[SUP] 1 [/SUP], Olivier Taton[SUP] 2 [/SUP], Alexandre Brasseur[SUP] 1 [/SUP], Yves Laurent[SUP] 3 [/SUP], Fabio Silvio Taccone[SUP] 1 [/SUP], Romain Courcelle[SUP] 3 [/SUP]
Affiliations
Abstract
Objectives: Venovenous extracorporeal membrane oxygenation has been largely used in patients with refractory acute respiratory distress syndrome due to coronavirus disease 2019. Few data on long-term pulmonary function among venovenous extracorporeal membrane oxygenation survivors are available.
Design: Retrospective, observational cohort.
Setting: Two mixed medical-surgical tertiary (30 beds) and secondary (22 beds) ICUs.
Patients: All critically ill adult coronavirus disease 2019 survivors treated with venovenous extracorporeal membrane oxygenation between March 10, and April 30, 2020.
Measurements and main results: The last available lung function and 6-minute walking tests, performed after a median of 178 days (ranges, 72-232 d) from ICU admission, were analyzed. Among the 32 coronavirus disease 2019 patients treated by venovenous extracorporeal membrane oxygenation during the study period, 11 (34%; median age 56 yr; median duration of mechanical ventilation and extracorporeal membrane oxygenation therapy of 26 and 15 d, respectively) were successfully weaned and discharged home. Spirometry was performed in nine patients; the volumetric lung function was preserved, that is, median forced vital capacity was 83% of predicted value (51-99% of predicted value), and median forced expiratory volume in 1 second was 82% of predicted value (60-99% of predicted value). Also, the median residual volume and the lung capacity were 100% of predicted value (50-140% of predicted value) and 90% of predicted value (50-100% of predicted value); only the diffusion capacity of the lung for carbon monoxide and 6-minute walking test were decreased (58% of predicted value [37-95% of predicted value] and 468 meters (365-625 meters), corresponding to [63-90% of predicted value], respectively).
Conclusions: Among survivors from severe coronavirus disease 2019 pneumonia treated with venovenous extracorporeal membrane oxygenation, preserved long-term volumetric lung function with decreased diffusion capacity of lung carbon monoxide was observed.
Keywords: acute respiratory distress syndrome; coronavirus disease 2019; extracorporeal membrane oxygenation; pulmonary function test.
. 2021 Jul 16;3(7):e0494.
doi: 10.1097/CCE.0000000000000494. eCollection 2021 Jul.
Six-Month Pulmonary Function After Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019 Patients
Amédée Ego[SUP] 1 [/SUP], Olivier Taton[SUP] 2 [/SUP], Alexandre Brasseur[SUP] 1 [/SUP], Yves Laurent[SUP] 3 [/SUP], Fabio Silvio Taccone[SUP] 1 [/SUP], Romain Courcelle[SUP] 3 [/SUP]
Affiliations
- PMID: 34291224
- PMCID: PMC8288889
- DOI: 10.1097/CCE.0000000000000494
Abstract
Objectives: Venovenous extracorporeal membrane oxygenation has been largely used in patients with refractory acute respiratory distress syndrome due to coronavirus disease 2019. Few data on long-term pulmonary function among venovenous extracorporeal membrane oxygenation survivors are available.
Design: Retrospective, observational cohort.
Setting: Two mixed medical-surgical tertiary (30 beds) and secondary (22 beds) ICUs.
Patients: All critically ill adult coronavirus disease 2019 survivors treated with venovenous extracorporeal membrane oxygenation between March 10, and April 30, 2020.
Measurements and main results: The last available lung function and 6-minute walking tests, performed after a median of 178 days (ranges, 72-232 d) from ICU admission, were analyzed. Among the 32 coronavirus disease 2019 patients treated by venovenous extracorporeal membrane oxygenation during the study period, 11 (34%; median age 56 yr; median duration of mechanical ventilation and extracorporeal membrane oxygenation therapy of 26 and 15 d, respectively) were successfully weaned and discharged home. Spirometry was performed in nine patients; the volumetric lung function was preserved, that is, median forced vital capacity was 83% of predicted value (51-99% of predicted value), and median forced expiratory volume in 1 second was 82% of predicted value (60-99% of predicted value). Also, the median residual volume and the lung capacity were 100% of predicted value (50-140% of predicted value) and 90% of predicted value (50-100% of predicted value); only the diffusion capacity of the lung for carbon monoxide and 6-minute walking test were decreased (58% of predicted value [37-95% of predicted value] and 468 meters (365-625 meters), corresponding to [63-90% of predicted value], respectively).
Conclusions: Among survivors from severe coronavirus disease 2019 pneumonia treated with venovenous extracorporeal membrane oxygenation, preserved long-term volumetric lung function with decreased diffusion capacity of lung carbon monoxide was observed.
Keywords: acute respiratory distress syndrome; coronavirus disease 2019; extracorporeal membrane oxygenation; pulmonary function test.