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Could Universal Donor Blood Be Made in the Laboratory? - JAMA

Mary Wilson

Well-known member
October 12, 2023

doi:10.1001/jama.2023.19288

Bridget M. Kuehn

In the face of chronic national and international blood supply shortages, scientists are renewing efforts to achieve the holy grail of transfusion—laboratory-made universal donor blood.​

Efforts are continuing along 2 parallel tracks. Some groups are testing the use of enzymes to convert type A or B blood into type O blood that most people can safely receive. The research has also advanced to preclinical studies of universal donor organs. Although obstacles remain, the work is demonstrating progress toward solving a persistent problem in health care.

The data so far provide proof of concept, according to Kamille West-Mitchell, MD, chief of the Blood Services Section at the National Institutes of Health Clinical Center in Bethesda, Maryland. “It is interesting and very exciting,” she said, “but we are not there yet.” ...



https://jamanetwork.com/journals/jama/fullarticle/2810760
 
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