Mary Wilson
Well-known member
March 22, 2023
DOI: 10.1056/NEJMc2215074
TO THE EDITOR:
Multisystem inflammatory syndrome in children (MIS-C), a delayed hyperinflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is an important cause of illness in children. Changes in the prevalent variant throughout the coronavirus disease 2019 pandemic have influenced the transmissibility and incidence of disease, but their association with clinical presentation and outcomes of MIS-C is incompletely known.[SUP]1,2[/SUP]
We used data from the International Kawasaki Disease Registry (IKDR) to identify patients who had been hospitalized with SARS-CoV-2 infection during the period from April 2020 through June 2022 and met the criteria for MIS-C according to the Centers for Disease Control and Prevention. All eligible patients who had provided written informed consent or assent with parental consent, as applicable according to local regulations, were enrolled in the study at the participating sites. Patients were enrolled retrospectively if they had been hospitalized before local approval of the study was obtained and prospectively thereafter. The Global Initiative on Sharing All Influenza Data (GISAID) database of hCoV-19 sequences was used to stratify the patients according to periods defined according to the predominant locally circulating ancestral or variant lineages in order to determine associations with changes in patient and disease characteristics.[SUP]3,4[/SUP] All comparisons were made against the ancestral period, and the 95% confidence intervals for the differences have not been adjusted for multiplicity and should not be used in place of hypothesis testing. ...
https://www.nejm.org/doi/full/10.10...+DM2168021_NEJM_Non_Subscriber&bid=1475293808
DOI: 10.1056/NEJMc2215074
TO THE EDITOR:
Multisystem inflammatory syndrome in children (MIS-C), a delayed hyperinflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is an important cause of illness in children. Changes in the prevalent variant throughout the coronavirus disease 2019 pandemic have influenced the transmissibility and incidence of disease, but their association with clinical presentation and outcomes of MIS-C is incompletely known.[SUP]1,2[/SUP]
We used data from the International Kawasaki Disease Registry (IKDR) to identify patients who had been hospitalized with SARS-CoV-2 infection during the period from April 2020 through June 2022 and met the criteria for MIS-C according to the Centers for Disease Control and Prevention. All eligible patients who had provided written informed consent or assent with parental consent, as applicable according to local regulations, were enrolled in the study at the participating sites. Patients were enrolled retrospectively if they had been hospitalized before local approval of the study was obtained and prospectively thereafter. The Global Initiative on Sharing All Influenza Data (GISAID) database of hCoV-19 sequences was used to stratify the patients according to periods defined according to the predominant locally circulating ancestral or variant lineages in order to determine associations with changes in patient and disease characteristics.[SUP]3,4[/SUP] All comparisons were made against the ancestral period, and the 95% confidence intervals for the differences have not been adjusted for multiplicity and should not be used in place of hypothesis testing. ...
https://www.nejm.org/doi/full/10.10...+DM2168021_NEJM_Non_Subscriber&bid=1475293808