tetano
Editor, Senior Moderator
Cornea
. 2021 Dec 15.
doi: 10.1097/ICO.0000000000002970. Online ahead of print.
Corneal Graft Rejection After Inactivated SARS-CoV-2 Vaccine: Case Report
Mariana Fernandez Simão[SUP] 1 [/SUP], Sérgio Kwitko
Affiliations
Abstract
Purpose: Our aim was to report the case of endothelial corneal allograft rejection after inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine with an atypical presentation.
Methods: This was a case report.
Results: A 63-year-old woman with previous penetrating keratoplasty and laser in situ keratomileusis presented with clinical signs of endothelial corneal graft rejection 24 hours after CoronaVac (SinoVac Biotech, Beijing/China) vaccine. Slitlamp examination showed corneal edema and interface fluid accumulation. It was partially resolved after treatment with topical corticosteroids and polydimethylsiloxane.
Conclusions: Corneal allograft rejection was already reported after another SARS-CoV-2 vaccine. This is the first report in the literature describing a possible association with inactivated SARS-CoV-2 vaccine and corneal allograft rejection, especially with laser in situ keratomileusis interface fluid accumulation presentation. Ophthalmologists should be aware of this potential complication.
. 2021 Dec 15.
doi: 10.1097/ICO.0000000000002970. Online ahead of print.
Corneal Graft Rejection After Inactivated SARS-CoV-2 Vaccine: Case Report
Mariana Fernandez Simão[SUP] 1 [/SUP], Sérgio Kwitko
Affiliations
- PMID: 34907940
- DOI: 10.1097/ICO.0000000000002970
Abstract
Purpose: Our aim was to report the case of endothelial corneal allograft rejection after inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine with an atypical presentation.
Methods: This was a case report.
Results: A 63-year-old woman with previous penetrating keratoplasty and laser in situ keratomileusis presented with clinical signs of endothelial corneal graft rejection 24 hours after CoronaVac (SinoVac Biotech, Beijing/China) vaccine. Slitlamp examination showed corneal edema and interface fluid accumulation. It was partially resolved after treatment with topical corticosteroids and polydimethylsiloxane.
Conclusions: Corneal allograft rejection was already reported after another SARS-CoV-2 vaccine. This is the first report in the literature describing a possible association with inactivated SARS-CoV-2 vaccine and corneal allograft rejection, especially with laser in situ keratomileusis interface fluid accumulation presentation. Ophthalmologists should be aware of this potential complication.