Comp Immunol Microbiol Infect Dis: Avian influenza virus [2009]

Laidback Al · Jun 21, 2011

Comparative Immunology, Microbiology and Infectious Diseases
Volume 32, Issue 4, July 2009, Pages 301-310

doi:10.1016/j.cimid.2008.01.007

Avian influenza virus

Chang-Won Lee and Yehia M. Saif
Department of Food Animal Health Research Program, Ohio Agricultural and Research Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, United States

Available online 23 May 2008.

Abstract

Avian influenza viruses do not typically replicate efficiently in humans, indicating direct transmission of avian influenza virus to humans is unlikely. However, since 1997, several cases of human infections with different subtypes (H5N1, H7N7, and H9N2) of avian influenza viruses have been identified and raised the pandemic potential of avian influenza virus in humans. Although circumstantial evidence of human to human transmission exists, the novel avian-origin influenza viruses isolated from humans lack the ability to transmit efficiently from person-to-person. However, the on-going human infection with avian-origin H5N1 viruses increases the likelihood of the generation of human-adapted avian influenza virus with pandemic potential. Thus, a better understanding of the biological and genetic basis of host restriction of influenza viruses is a critical factor in determining whether the introduction of a novel influenza virus into the human population will result in a pandemic. In this article, we review current knowledge of type A influenza virus in which all avian influenza viruses are categorized.

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Comp Immunol Microbiol Infect Dis: Avian influenza virus [2009]

Laidback Al

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