tetano
Editor, Senior Moderator
Commun Biol
. 2020 Oct 9;3(1):564.
doi: 10.1038/s42003-020-01278-5.
Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets
Koen van de Ven[SUP] 1 [/SUP], Femke de Heij[SUP] 1 2 [/SUP], Harry van Dijken[SUP] 1 [/SUP], Jos? A Ferreira[SUP] 3 [/SUP], J?rgen de Jonge[SUP] 4 [/SUP]
Affiliations
Abstract
Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets are a more potent model for studying immune correlates of protection in influenza infection. We therefore set out to investigate the role of systemic and respiratory T cells in the protection against heterosubtypic influenza A infections in ferrets. H1N1-priming induced systemic and respiratory T cells that responded against pandemic H2N2 and correlated with reduced viral replication and disease. CD8-positive T cell responses in the upper and lower respiratory tract were exceptionally high. We additionally confirmed that H2N2-responsive T cells are present in healthy human blood donors. These findings underline the importance of the T cell response in influenza immunity and show that T cells are a potent target for future universal influenza vaccines.
. 2020 Oct 9;3(1):564.
doi: 10.1038/s42003-020-01278-5.
Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets
Koen van de Ven[SUP] 1 [/SUP], Femke de Heij[SUP] 1 2 [/SUP], Harry van Dijken[SUP] 1 [/SUP], Jos? A Ferreira[SUP] 3 [/SUP], J?rgen de Jonge[SUP] 4 [/SUP]
Affiliations
- PMID: 33037319
- DOI: 10.1038/s42003-020-01278-5
Abstract
Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets are a more potent model for studying immune correlates of protection in influenza infection. We therefore set out to investigate the role of systemic and respiratory T cells in the protection against heterosubtypic influenza A infections in ferrets. H1N1-priming induced systemic and respiratory T cells that responded against pandemic H2N2 and correlated with reduced viral replication and disease. CD8-positive T cell responses in the upper and lower respiratory tract were exceptionally high. We additionally confirmed that H2N2-responsive T cells are present in healthy human blood donors. These findings underline the importance of the T cell response in influenza immunity and show that T cells are a potent target for future universal influenza vaccines.