tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2014 May 7. doi: 10.1111/irv.12255. [Epub ahead of print]
Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children.
Asner SA1, Petrich A, Hamid JS, Mertz D, Richardson SE, Smieja M.
Author information
Abstract
BACKGROUND:
Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remain limited.
OBJECTIVES:
We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU), and other common respiratory viruses in children.
PATIENTS/METHODS:
Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization >5 days, oxygen requirements or death.
RESULTS:
A total of 116 HRV/ENT, 102 RSV, 99 FLU, and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37?9% versus 13?6%; P < 0?001), FLU (37?9% versus 22%; P = 0?018) or any other single viral infection (37?9% versus 22?5%; P = 0?024). In multivariable analysis adjusted for underlying conditions and age, children with HRV/ENT infections had increased odds of hospitalization compared to children with RSV infections (OR 2?6; 95% CI 1?4, 4?8; P < 0?003) or FLU infections (OR 3?0; 95% CI 1?6, 5?8; <0?001) and increased odds of severe clinical disease among inpatients (OR 3?0; 95% CI 1?6,5?6; P = 0?001) when compared to those with FLU infections.
CONCLUSIONS:
Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections.
? 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
Clinical disease severity, human rhinovirus/enterovirus, influenza, respiratory syncytial virus, single viral infections
PMID:
24801963
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24801963
Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children.
Asner SA1, Petrich A, Hamid JS, Mertz D, Richardson SE, Smieja M.
Author information
Abstract
BACKGROUND:
Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remain limited.
OBJECTIVES:
We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU), and other common respiratory viruses in children.
PATIENTS/METHODS:
Retrospective study of children with ARIs and confirmed single positive viral infections on mid-turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization >5 days, oxygen requirements or death.
RESULTS:
A total of 116 HRV/ENT, 102 RSV, 99 FLU, and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37?9% versus 13?6%; P < 0?001), FLU (37?9% versus 22%; P = 0?018) or any other single viral infection (37?9% versus 22?5%; P = 0?024). In multivariable analysis adjusted for underlying conditions and age, children with HRV/ENT infections had increased odds of hospitalization compared to children with RSV infections (OR 2?6; 95% CI 1?4, 4?8; P < 0?003) or FLU infections (OR 3?0; 95% CI 1?6, 5?8; <0?001) and increased odds of severe clinical disease among inpatients (OR 3?0; 95% CI 1?6,5?6; P = 0?001) when compared to those with FLU infections.
CONCLUSIONS:
Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections.
? 2014 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
KEYWORDS:
Clinical disease severity, human rhinovirus/enterovirus, influenza, respiratory syncytial virus, single viral infections
PMID:
24801963
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24801963