tetano
Editor, Senior Moderator
PLoS One. 2018 Mar 28;13(3):e0194138. doi: 10.1371/journal.pone.0194138. eCollection 2018.
[h=1]Clinical and epidemiological characterization of influenza virus infections in children with severe acute respiratory infection in Maputo, Mozambique: Results from the implementation of sentinel surveillance, 2014 - 2016.[/h] Nguenha N[SUP]1[/SUP], Tivane A[SUP]1[/SUP], Pale M[SUP]1[/SUP], Machalele L[SUP]1[/SUP], Nacoto A[SUP]1[/SUP], Pires G[SUP]1[/SUP], Mationane E[SUP]1[/SUP], Sal?ncia J[SUP]1,[/SUP][SUP]2[/SUP], Gundane F[SUP]1,[/SUP][SUP]2[/SUP], Muteto D[SUP]3[/SUP], Chilundo J[SUP]3[/SUP], Mavale S[SUP]3[/SUP], Adamo N[SUP]1[/SUP], Sem?-Baltazar C[SUP]1[/SUP], Augusto O[SUP]4[/SUP], Gudo E[SUP]1[/SUP], Muss? T[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In Sub-Saharan Africa, where burden, impact, and incidence of acute respiratory infections (ARI) are the highest in the world, conversely, the epidemiology of influenza-associated severe acute respiratory infections (SARI) is incompletely known. The aim of this study was to describe the clinical and epidemiological features of influenza-associated SARI in hospitalized children in Maputo city, Mozambique. Nasopharyngeal and oropharyngeal swabs were collected from children aged 0-14 years old who met the case definition for SARI in two hospitals in Maputo city after their parents or legal representative consented to participate. A structured questionnaire was used to collect clinical and demographic data. Typing and subtyping of influenza were performed by real-time PCR. From January 2014 to December 2016, a total of 2,007 eligible children were recruited, of whom 1,997 (99.5%) were screened for influenza by real-time PCR. The median age of participants was 16.9 months (IQR: 7.0-38.9 months) and 53.9% (1076/1991) were male. A total of 77 were positive for influenza, yielding a frequency of 3.9% (77/1,991), with the highest frequency being reported in the age group 1-5 years old. Cases of influenza peaked twice each year, during which, its frequency reached up to 60%-80%. Among all influenza confirmed cases, 33.7% (26/77), 35.1% (27/77) and 28.6% (22/77) were typed as influenza A/H3N2, A/H1N1pdm09, and B, respectively. This represents the first report of influenza in urban/sub urban setting in Mozambique and the first evidence of distribution of strains of influenza in the country. Our data showed that frequency of influenza was lower than reported in a rural setting in Mozambique and the frequency of seasonal (A/H1N1pdm09) and (A/H3N2) subtypes were similar in children with SARI.
PMID: 29590162 DOI: 10.1371/journal.pone.0194138
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[h=1]Clinical and epidemiological characterization of influenza virus infections in children with severe acute respiratory infection in Maputo, Mozambique: Results from the implementation of sentinel surveillance, 2014 - 2016.[/h] Nguenha N[SUP]1[/SUP], Tivane A[SUP]1[/SUP], Pale M[SUP]1[/SUP], Machalele L[SUP]1[/SUP], Nacoto A[SUP]1[/SUP], Pires G[SUP]1[/SUP], Mationane E[SUP]1[/SUP], Sal?ncia J[SUP]1,[/SUP][SUP]2[/SUP], Gundane F[SUP]1,[/SUP][SUP]2[/SUP], Muteto D[SUP]3[/SUP], Chilundo J[SUP]3[/SUP], Mavale S[SUP]3[/SUP], Adamo N[SUP]1[/SUP], Sem?-Baltazar C[SUP]1[/SUP], Augusto O[SUP]4[/SUP], Gudo E[SUP]1[/SUP], Muss? T[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In Sub-Saharan Africa, where burden, impact, and incidence of acute respiratory infections (ARI) are the highest in the world, conversely, the epidemiology of influenza-associated severe acute respiratory infections (SARI) is incompletely known. The aim of this study was to describe the clinical and epidemiological features of influenza-associated SARI in hospitalized children in Maputo city, Mozambique. Nasopharyngeal and oropharyngeal swabs were collected from children aged 0-14 years old who met the case definition for SARI in two hospitals in Maputo city after their parents or legal representative consented to participate. A structured questionnaire was used to collect clinical and demographic data. Typing and subtyping of influenza were performed by real-time PCR. From January 2014 to December 2016, a total of 2,007 eligible children were recruited, of whom 1,997 (99.5%) were screened for influenza by real-time PCR. The median age of participants was 16.9 months (IQR: 7.0-38.9 months) and 53.9% (1076/1991) were male. A total of 77 were positive for influenza, yielding a frequency of 3.9% (77/1,991), with the highest frequency being reported in the age group 1-5 years old. Cases of influenza peaked twice each year, during which, its frequency reached up to 60%-80%. Among all influenza confirmed cases, 33.7% (26/77), 35.1% (27/77) and 28.6% (22/77) were typed as influenza A/H3N2, A/H1N1pdm09, and B, respectively. This represents the first report of influenza in urban/sub urban setting in Mozambique and the first evidence of distribution of strains of influenza in the country. Our data showed that frequency of influenza was lower than reported in a rural setting in Mozambique and the frequency of seasonal (A/H1N1pdm09) and (A/H3N2) subtypes were similar in children with SARI.
PMID: 29590162 DOI: 10.1371/journal.pone.0194138
Free full text