tetano
Editor, Senior Moderator
Clin Transl Gastroenterol
. 2021 Jan 12;12(1):e00293.
doi: 10.14309/ctg.0000000000000293.
Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19
Felix Grabherr[SUP] 1 [/SUP], Maria Effenberger[SUP] 1 [/SUP], Alisa Pedrini[SUP] 1 [/SUP], Lisa Mayr[SUP] 1 [/SUP], Julian Schw?rzler[SUP] 1 [/SUP], Simon Reider[SUP] 1 [/SUP], Barbara Enrich[SUP] 1 [/SUP], Gernot Fritsche[SUP] 2 [/SUP], Sophie Wildner[SUP] 2 [/SUP], Rosa Bellmann-Weiler[SUP] 2 [/SUP], G?nter Weiss[SUP] 2 [/SUP], Sabine Scholl-B?rgi[SUP] 3 [/SUP], Thomas M?ller[SUP] 3 [/SUP], Alexander Moschen[SUP] 1 [/SUP], Timon E Adolph[SUP] 1 [/SUP], Herbert Tilg[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus disease (COVID-19) has spread from Wuhan, China, and become a worldwide pandemic. Most patients display respiratory symptoms but up to 50% report gastrointestinal symptoms. Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-γ.
Methods: We measured fecal neopterin in 37 hospitalized COVID-19 patients not requiring intensive care measures and 22 healthy controls.
Results: Fecal neopterin was elevated in stool samples from COVID-19 patients compared with that in samples from healthy controls. Especially, patients reporting gastrointestinal symptoms exhibited increased fecal neopterin values.
Discussion: COVID-19 is associated with an inflammatory immune response in the gastrointestinal tract.
. 2021 Jan 12;12(1):e00293.
doi: 10.14309/ctg.0000000000000293.
Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19
Felix Grabherr[SUP] 1 [/SUP], Maria Effenberger[SUP] 1 [/SUP], Alisa Pedrini[SUP] 1 [/SUP], Lisa Mayr[SUP] 1 [/SUP], Julian Schw?rzler[SUP] 1 [/SUP], Simon Reider[SUP] 1 [/SUP], Barbara Enrich[SUP] 1 [/SUP], Gernot Fritsche[SUP] 2 [/SUP], Sophie Wildner[SUP] 2 [/SUP], Rosa Bellmann-Weiler[SUP] 2 [/SUP], G?nter Weiss[SUP] 2 [/SUP], Sabine Scholl-B?rgi[SUP] 3 [/SUP], Thomas M?ller[SUP] 3 [/SUP], Alexander Moschen[SUP] 1 [/SUP], Timon E Adolph[SUP] 1 [/SUP], Herbert Tilg[SUP] 1 [/SUP]
Affiliations
- PMID: 33438988
- PMCID: PMC7806232
- DOI: 10.14309/ctg.0000000000000293
Abstract
Introduction: Coronavirus disease (COVID-19) has spread from Wuhan, China, and become a worldwide pandemic. Most patients display respiratory symptoms but up to 50% report gastrointestinal symptoms. Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-γ.
Methods: We measured fecal neopterin in 37 hospitalized COVID-19 patients not requiring intensive care measures and 22 healthy controls.
Results: Fecal neopterin was elevated in stool samples from COVID-19 patients compared with that in samples from healthy controls. Especially, patients reporting gastrointestinal symptoms exhibited increased fecal neopterin values.
Discussion: COVID-19 is associated with an inflammatory immune response in the gastrointestinal tract.