tetano
Editor, Senior Moderator
Clin Rheumatol
. 2021 Feb 15.
doi: 10.1007/s10067-020-05550-1. Online ahead of print.
Post-COVID-19 arthritis: a case report and literature review
M Gasparotto[SUP] #[/SUP][SUP] 1 [/SUP], V Framba[SUP] #[/SUP][SUP] 2 [/SUP], C Piovella[SUP] 2 [/SUP], A Doria[SUP] 1 [/SUP], Luca Iaccarino[SUP] 3 4 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the novel pathogen responsible for the coronavirus disease 19 (COVID-19) outbreak. Researchers and clinicians are exploring the pathogenetic mechanisms of the viral-induced damage and growing interest is focusing on the short-term and long-term immune-mediated consequences triggered by the infection. We will focus on post-SARS-CoV2 infection arthritis which may arise as a new pathological condition associated with COVID-19. In this article, we describe a case of acute oligoarthritis occurring 13 days after a SARS-CoV2 severe pneumonia in a middle-aged Caucasian man and we go over a brief review of the current available literature. We hypothesize that molecular mimicry might be the basic immunological mechanism responsible for the onset of COVID-19-related arthritis based on the current knowledge of SARS-CoV2 and on the known pathogenetic mechanism of viral-induced arthritis.
Keywords: Arthritis; COVID-19; Molecular mimicry; Reactive arthritis; SARS-CoV2.
. 2021 Feb 15.
doi: 10.1007/s10067-020-05550-1. Online ahead of print.
Post-COVID-19 arthritis: a case report and literature review
M Gasparotto[SUP] #[/SUP][SUP] 1 [/SUP], V Framba[SUP] #[/SUP][SUP] 2 [/SUP], C Piovella[SUP] 2 [/SUP], A Doria[SUP] 1 [/SUP], Luca Iaccarino[SUP] 3 4 [/SUP]
Affiliations
- PMID: 33587197
- DOI: 10.1007/s10067-020-05550-1
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the novel pathogen responsible for the coronavirus disease 19 (COVID-19) outbreak. Researchers and clinicians are exploring the pathogenetic mechanisms of the viral-induced damage and growing interest is focusing on the short-term and long-term immune-mediated consequences triggered by the infection. We will focus on post-SARS-CoV2 infection arthritis which may arise as a new pathological condition associated with COVID-19. In this article, we describe a case of acute oligoarthritis occurring 13 days after a SARS-CoV2 severe pneumonia in a middle-aged Caucasian man and we go over a brief review of the current available literature. We hypothesize that molecular mimicry might be the basic immunological mechanism responsible for the onset of COVID-19-related arthritis based on the current knowledge of SARS-CoV2 and on the known pathogenetic mechanism of viral-induced arthritis.
Keywords: Arthritis; COVID-19; Molecular mimicry; Reactive arthritis; SARS-CoV2.