tetano
Editor, Senior Moderator
Clin Respir J
. 2022 Jan 21.
doi: 10.1111/crj.13467. Online ahead of print.
Risk assessment of venous thromboembolism and bleeding in COVID-19 patients
Lan Wang[SUP] 1 2 [/SUP], Lan Zhao[SUP] 1 3 [/SUP], Feng Li[SUP] 1 [/SUP], Ji Liu[SUP] 1 4 [/SUP], Li Zhang[SUP] 1 3 [/SUP], Qiuhong Li[SUP] 1 3 [/SUP], Jin Gu[SUP] 1 5 [/SUP], Shuo Liang[SUP] 1 3 [/SUP], Qinhua Zhao[SUP] 2 [/SUP], Jinmin Liu[SUP] 2 [/SUP], Jin-Fu Xu[SUP] 1 3 [/SUP]
Affiliations
Abstract
Background: The coronavirus disease 2019 (COVID-19) is a newly recognized illness that has spread rapidly all over the world. More and more reports highlight the risk of venous thromboembolism (VTE) in COVID-19. Our study aims to identify in-hospital VTE risk and bleeding risk in COVID-19 patients.
Methods: We retrospectively studied 138 consecutively enrolled patients with COVID-19 and identified in-hospital VTE and bleeding risk by Padua Prediction Score and Improve bleed risk assessment model. The clinical data and features were analyzed in VTE patients.
Results: Our findings identified that 23 (16.7%) patients with COVID-19 were at high risk for VTE according to Padua prediction score and 9 (6.5%) patients were at high risk of bleeding for VTE prophylaxis according to Improve prediction score. Fifteen critically ill patients faced double high risk from thrombosis (Padua score more than 4 points in all 15 [100%] patients) and hemorrhage (Improve score more than 7 points in 9 [60.0%] patients). Thrombotic events were identified in four patients (2.9%) of all COVID-19 patients. All of them were diagnosed with deep vein thrombosis by ultrasound 3 to 18 days after admission. Three (75.0%) were critically ill patients, which means that the incidence of VTE among critically ill patients was 20%. One major hemorrhage happened in critically ill patients during VTE treatment.
Conclusion: Critically ill patients with COVID-19 suffered both a high risk of thrombosis and bleeding risks. More effective VTE prevention strategies based on an individual assessment of bleeding risks were necessary for critically ill patients with COVID-19.
Keywords: Padua prediction score; coronavirus disease 2019; deep vein thrombosis; improve bleed risk assessment model; venous thromboembolism.
. 2022 Jan 21.
doi: 10.1111/crj.13467. Online ahead of print.
Risk assessment of venous thromboembolism and bleeding in COVID-19 patients
Lan Wang[SUP] 1 2 [/SUP], Lan Zhao[SUP] 1 3 [/SUP], Feng Li[SUP] 1 [/SUP], Ji Liu[SUP] 1 4 [/SUP], Li Zhang[SUP] 1 3 [/SUP], Qiuhong Li[SUP] 1 3 [/SUP], Jin Gu[SUP] 1 5 [/SUP], Shuo Liang[SUP] 1 3 [/SUP], Qinhua Zhao[SUP] 2 [/SUP], Jinmin Liu[SUP] 2 [/SUP], Jin-Fu Xu[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35060325
- DOI: 10.1111/crj.13467
Abstract
Background: The coronavirus disease 2019 (COVID-19) is a newly recognized illness that has spread rapidly all over the world. More and more reports highlight the risk of venous thromboembolism (VTE) in COVID-19. Our study aims to identify in-hospital VTE risk and bleeding risk in COVID-19 patients.
Methods: We retrospectively studied 138 consecutively enrolled patients with COVID-19 and identified in-hospital VTE and bleeding risk by Padua Prediction Score and Improve bleed risk assessment model. The clinical data and features were analyzed in VTE patients.
Results: Our findings identified that 23 (16.7%) patients with COVID-19 were at high risk for VTE according to Padua prediction score and 9 (6.5%) patients were at high risk of bleeding for VTE prophylaxis according to Improve prediction score. Fifteen critically ill patients faced double high risk from thrombosis (Padua score more than 4 points in all 15 [100%] patients) and hemorrhage (Improve score more than 7 points in 9 [60.0%] patients). Thrombotic events were identified in four patients (2.9%) of all COVID-19 patients. All of them were diagnosed with deep vein thrombosis by ultrasound 3 to 18 days after admission. Three (75.0%) were critically ill patients, which means that the incidence of VTE among critically ill patients was 20%. One major hemorrhage happened in critically ill patients during VTE treatment.
Conclusion: Critically ill patients with COVID-19 suffered both a high risk of thrombosis and bleeding risks. More effective VTE prevention strategies based on an individual assessment of bleeding risks were necessary for critically ill patients with COVID-19.
Keywords: Padua prediction score; coronavirus disease 2019; deep vein thrombosis; improve bleed risk assessment model; venous thromboembolism.