tetano
Editor, Senior Moderator
Clin Med Insights Endocrinol Diabetes
. 2021 Mar 24;14:1179551421990675.
doi: 10.1177/1179551421990675. eCollection 2021.
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression
Indriwanto Sakidjan Atmosudigdo[SUP] 1 [/SUP], Michael Anthonius Lim[SUP] 2 [/SUP], Basuni Radi[SUP] 1 [/SUP], Joshua Henrina[SUP] 3 [/SUP], Emir Yonas[SUP] 4 [/SUP], Rachel Vania[SUP] 2 5 [/SUP], Raymond Pranata[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.
Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study's main outcome is a poor composite outcome, comprising of mortality and severe COVID-19.
Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P = .010; I [SUP]2[/SUP]: 56.7%, P = .018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P = .008; I [SUP]2[/SUP]: 57.4%, P = .029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: -0.04, P = .033), male gender (coefficient: -0.03, P = .042), and hypertension (coefficient: -0.02, P = .033), but not diabetes (coefficient: -0.24, P = .135) and cardiovascular diseases (coefficient: -0.01, P = .506). Inverted funnel-plot was relatively symmetrical. Egger's test indicates that the pooled analysis was not statistically significant for small-study effects (P = .206).
Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension.PROSPERO Registration Number: CRD42020213491.
Keywords: COVID-19; coronavirus; dyslipidemia; hyperlipidemia; prognosis.
. 2021 Mar 24;14:1179551421990675.
doi: 10.1177/1179551421990675. eCollection 2021.
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression
Indriwanto Sakidjan Atmosudigdo[SUP] 1 [/SUP], Michael Anthonius Lim[SUP] 2 [/SUP], Basuni Radi[SUP] 1 [/SUP], Joshua Henrina[SUP] 3 [/SUP], Emir Yonas[SUP] 4 [/SUP], Rachel Vania[SUP] 2 5 [/SUP], Raymond Pranata[SUP] 2 [/SUP]
Affiliations
- PMID: 35173508
- PMCID: PMC8842489
- DOI: 10.1177/1179551421990675
Abstract
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.
Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study's main outcome is a poor composite outcome, comprising of mortality and severe COVID-19.
Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P = .010; I [SUP]2[/SUP]: 56.7%, P = .018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P = .008; I [SUP]2[/SUP]: 57.4%, P = .029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: -0.04, P = .033), male gender (coefficient: -0.03, P = .042), and hypertension (coefficient: -0.02, P = .033), but not diabetes (coefficient: -0.24, P = .135) and cardiovascular diseases (coefficient: -0.01, P = .506). Inverted funnel-plot was relatively symmetrical. Egger's test indicates that the pooled analysis was not statistically significant for small-study effects (P = .206).
Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension.PROSPERO Registration Number: CRD42020213491.
Keywords: COVID-19; coronavirus; dyslipidemia; hyperlipidemia; prognosis.