tetano
Editor, Senior Moderator
Clin Kidney J
. 2020 May 9;13(3):340-346.
doi: 10.1093/ckj/sfaa083. eCollection 2020 Jun.
Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study
Daqing Hong[SUP] 1 [/SUP], Lin Long[SUP] 2 [/SUP], Amanda Y Wang[SUP] 3 4 5 [/SUP], Yu Lei[SUP] 6 [/SUP], Yun Tang[SUP] 1 [/SUP], Jia Wei Zhao[SUP] 7 [/SUP], Xiaofei Song[SUP] 3 4 5 [/SUP], Yanan He[SUP] 3 4 5 [/SUP], Ergang Wen[SUP] 1 [/SUP], Ling Zheng[SUP] 1 [/SUP], Guisen Li[SUP] 1 [/SUP], Li Wang[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 3 million patients globally. Previous data from Wuhan city showed that acute kidney injury (AKI), proteinuria and hematuria occurred frequently in patients with severe COVID-19. However, the prevalence of kidney injury in milder cases remains unclear.
Methods: This retrospective study included two major consecutive cohorts of COVID-19 patients in Sichuan Province. Baseline characteristics, laboratory data including renal function, proteinuria and dipstick hematuria, and other laboratory parameters were collected. A subgroup of patients was followed up for 2-4 weeks to evaluate the short-term outcome of renal impairment.
Results: Overall, 168 COVID-19-positive patients were included in the study. The majority of patients (79.7%) were diagnosed with mild or moderate disease. Half of patients presented with fever; however, in The Tibetan cohort, fever only occurred in 13.4% of patients. On hospital admission, proteinuria and dipstick hematuria were noted in 18.4% and 17.4% of patients, respectively, while AKI only occurred in one patient. Further analysis showed that severe or critical COVID-19 was associated with higher risk of proteinuria [relative risk (RR) 7.37, 95% confidence interval (CI) 2.45-22.18, P = 3.8 ? 10[SUP]-4[/SUP]] and dipstick hematuria (RR 8.30, 95% CI 2.69-25.56, P = 2.3 ? 10[SUP]-4[/SUP]). Proteinuria, dipstick hematuria, or the combination of proteinuria and hematuria could significantly predict severe or critical severe COVID-19.
Conclusions: Proteinuria and dipstick hematuria are not uncommon in patients with COVID-19 infection, especially in severe or critical cases.
Keywords: COVID-19; acute kidney injury.
. 2020 May 9;13(3):340-346.
doi: 10.1093/ckj/sfaa083. eCollection 2020 Jun.
Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study
Daqing Hong[SUP] 1 [/SUP], Lin Long[SUP] 2 [/SUP], Amanda Y Wang[SUP] 3 4 5 [/SUP], Yu Lei[SUP] 6 [/SUP], Yun Tang[SUP] 1 [/SUP], Jia Wei Zhao[SUP] 7 [/SUP], Xiaofei Song[SUP] 3 4 5 [/SUP], Yanan He[SUP] 3 4 5 [/SUP], Ergang Wen[SUP] 1 [/SUP], Ling Zheng[SUP] 1 [/SUP], Guisen Li[SUP] 1 [/SUP], Li Wang[SUP] 1 [/SUP]
Affiliations
- PMID: 32695324
- PMCID: PMC7239220
- DOI: 10.1093/ckj/sfaa083
Abstract
Background: Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 3 million patients globally. Previous data from Wuhan city showed that acute kidney injury (AKI), proteinuria and hematuria occurred frequently in patients with severe COVID-19. However, the prevalence of kidney injury in milder cases remains unclear.
Methods: This retrospective study included two major consecutive cohorts of COVID-19 patients in Sichuan Province. Baseline characteristics, laboratory data including renal function, proteinuria and dipstick hematuria, and other laboratory parameters were collected. A subgroup of patients was followed up for 2-4 weeks to evaluate the short-term outcome of renal impairment.
Results: Overall, 168 COVID-19-positive patients were included in the study. The majority of patients (79.7%) were diagnosed with mild or moderate disease. Half of patients presented with fever; however, in The Tibetan cohort, fever only occurred in 13.4% of patients. On hospital admission, proteinuria and dipstick hematuria were noted in 18.4% and 17.4% of patients, respectively, while AKI only occurred in one patient. Further analysis showed that severe or critical COVID-19 was associated with higher risk of proteinuria [relative risk (RR) 7.37, 95% confidence interval (CI) 2.45-22.18, P = 3.8 ? 10[SUP]-4[/SUP]] and dipstick hematuria (RR 8.30, 95% CI 2.69-25.56, P = 2.3 ? 10[SUP]-4[/SUP]). Proteinuria, dipstick hematuria, or the combination of proteinuria and hematuria could significantly predict severe or critical severe COVID-19.
Conclusions: Proteinuria and dipstick hematuria are not uncommon in patients with COVID-19 infection, especially in severe or critical cases.
Keywords: COVID-19; acute kidney injury.