tetano
Editor, Senior Moderator
Clin Infect Dis
. 2021 May 22;ciab432.
doi: 10.1093/cid/ciab432. Online ahead of print.
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection - Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020 -March 5, 2021
Romeo R Galang[SUP] 1 [/SUP], Suzanne M Newton[SUP] 1 [/SUP], Kate R Woodworth[SUP] 1 [/SUP], Isabel Griffin[SUP] 1 [/SUP], Titilope Oduyebo[SUP] 1 [/SUP], Christina L Sancken[SUP] 1 [/SUP], Emily O'Malley Olsen[SUP] 1 [/SUP], Kathryn Aveni[SUP] 2 [/SUP], Heather Wingate[SUP] 3 [/SUP], Hanna Shephard[SUP] 4 [/SUP], Chris Fussman[SUP] 5 [/SUP], Zahra S Alaali[SUP] 6 [/SUP], Kristin Silcox[SUP] 7 [/SUP], Samantha Siebman[SUP] 8 [/SUP], Umme-Aiman Halai[SUP] 9 [/SUP], Camille Delgado Lopez[SUP] 10 [/SUP], Mamie Lush[SUP] 11 [/SUP], Ayomide Sokale[SUP] 12 [/SUP], Jerusha Barton[SUP] 13 [/SUP], Ifrah Chaudhary[SUP] 14 [/SUP], Paul H Patrick[SUP] 15 [/SUP], Levi Schlosser[SUP] 16 [/SUP], Bethany Reynolds[SUP] 17 [/SUP], Nicole Gaarenstroom[SUP] 18 [/SUP], Sarah Chicchelly[SUP] 19 [/SUP], Jennifer S Read[SUP] 20 21 [/SUP], Leah de Wilde[SUP] 22 [/SUP], Deborah Mbotha[SUP] 23 [/SUP], Eduardo Azziz-Baumgartner[SUP] 1 [/SUP], Aron J Hall[SUP] 1 [/SUP], Van T Tong[SUP] 1 [/SUP], Sascha Ellington[SUP] 1 [/SUP], Suzanne M Gilboa[SUP] 1 [/SUP], CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team
Affiliations
Abstract
Background: Pregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with COVID-19 are limited. This study aimed to determine risk factors associated with COVID-19 illness severity among pregnant women with SARS-CoV-2 infection.
Methods: Pregnant women with SARS-CoV-2 infection confirmed by molecular testing were reported during March 29, 2020-March 5, 2021 through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). Criteria for illness severity (asymptomatic, mild, moderate-to-severe, or critical) were adapted from National Institutes of Health and World Health Organization criteria. Crude and adjusted risk ratios for moderate-to-severe or critical COVID-19 illness were calculated for selected demographic and clinical characteristics.
Results: Among 7,950 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 25 years and older, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions.
Conclusions: Older age and having underlying medical conditions were associated with increased risk of moderate-to-severe or critical COVID-19 illness among pregnant women. This information might help pregnant women understand their risk for moderate-to-severe or critical COVID-19 illness and inform targeted public health messaging.
Keywords: COVID-19; SARS-CoV-2; illness severity; pregnancy; risk factors.
. 2021 May 22;ciab432.
doi: 10.1093/cid/ciab432. Online ahead of print.
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection - Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020 -March 5, 2021
Romeo R Galang[SUP] 1 [/SUP], Suzanne M Newton[SUP] 1 [/SUP], Kate R Woodworth[SUP] 1 [/SUP], Isabel Griffin[SUP] 1 [/SUP], Titilope Oduyebo[SUP] 1 [/SUP], Christina L Sancken[SUP] 1 [/SUP], Emily O'Malley Olsen[SUP] 1 [/SUP], Kathryn Aveni[SUP] 2 [/SUP], Heather Wingate[SUP] 3 [/SUP], Hanna Shephard[SUP] 4 [/SUP], Chris Fussman[SUP] 5 [/SUP], Zahra S Alaali[SUP] 6 [/SUP], Kristin Silcox[SUP] 7 [/SUP], Samantha Siebman[SUP] 8 [/SUP], Umme-Aiman Halai[SUP] 9 [/SUP], Camille Delgado Lopez[SUP] 10 [/SUP], Mamie Lush[SUP] 11 [/SUP], Ayomide Sokale[SUP] 12 [/SUP], Jerusha Barton[SUP] 13 [/SUP], Ifrah Chaudhary[SUP] 14 [/SUP], Paul H Patrick[SUP] 15 [/SUP], Levi Schlosser[SUP] 16 [/SUP], Bethany Reynolds[SUP] 17 [/SUP], Nicole Gaarenstroom[SUP] 18 [/SUP], Sarah Chicchelly[SUP] 19 [/SUP], Jennifer S Read[SUP] 20 21 [/SUP], Leah de Wilde[SUP] 22 [/SUP], Deborah Mbotha[SUP] 23 [/SUP], Eduardo Azziz-Baumgartner[SUP] 1 [/SUP], Aron J Hall[SUP] 1 [/SUP], Van T Tong[SUP] 1 [/SUP], Sascha Ellington[SUP] 1 [/SUP], Suzanne M Gilboa[SUP] 1 [/SUP], CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team
Affiliations
- PMID: 34021332
- DOI: 10.1093/cid/ciab432
Abstract
Background: Pregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with COVID-19 are limited. This study aimed to determine risk factors associated with COVID-19 illness severity among pregnant women with SARS-CoV-2 infection.
Methods: Pregnant women with SARS-CoV-2 infection confirmed by molecular testing were reported during March 29, 2020-March 5, 2021 through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). Criteria for illness severity (asymptomatic, mild, moderate-to-severe, or critical) were adapted from National Institutes of Health and World Health Organization criteria. Crude and adjusted risk ratios for moderate-to-severe or critical COVID-19 illness were calculated for selected demographic and clinical characteristics.
Results: Among 7,950 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 25 years and older, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions.
Conclusions: Older age and having underlying medical conditions were associated with increased risk of moderate-to-severe or critical COVID-19 illness among pregnant women. This information might help pregnant women understand their risk for moderate-to-severe or critical COVID-19 illness and inform targeted public health messaging.
Keywords: COVID-19; SARS-CoV-2; illness severity; pregnancy; risk factors.