tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 Feb 17;ciac101.
doi: 10.1093/cid/ciac101. Online ahead of print.
Prenatal influenza vaccination or influenza infection and autism spectrum disorder in offspring
Tracy A Becerra-Culqui[SUP] 1 2 [/SUP], Darios Getahun[SUP] 1 3 [/SUP], Vicki Chiu[SUP] 1 [/SUP], Lina S Sy[SUP] 1 [/SUP], Hung Fu Tseng[SUP] 1 3 [/SUP]
Affiliations
Abstract
Background: As prenatal vaccinations continue to be given more frequently, it is important to assess long-term safety events. This study investigates the association between prenatal influenza vaccination or infection and autism spectrum disorder (ASD) risk in offspring.
Methods: Retrospective cohort study of mother-child pairs with deliveries 1/1/2011-12/31/2014 at Kaiser Permanente Southern California was performed. Children >1 year were followed through 12/31/2018. Maternal influenza vaccination or infection during pregnancy was obtained from electronic health records. ASD was defined by International Classification of Diseases, 9th/10th Revision codes after age 1 year. Cox proportional hazards models estimated the crude and inverse probability of treatment weighted (IPTW) hazard ratios (HR) for the association between maternal influenza vaccination or infection and ASD.
Results: There were 84,739 mother-child pairs included in the final analytic sample. Maternal vaccination coverage increased slightly over time, from 52.7% for 2011 births to 59.6% for 2014 births. Of the 46,257 women vaccinated, 32.4% were vaccinated during the 1 st trimester, 41.8% during the 2 nd trimester, and 25.8% during the 3 rd trimester. ASD was diagnosed in 1,930 (2.3%) children. The IPTW analyses showed no association between prenatal influenza vaccination or infection and ASD in offspring (HR: 1.04, 95% confidence interval [CI]: 0.95, 1.13; HR: 1.12, 95% CI: 0.66, 1.89, respectively).
Conclusions: Prenatal influenza vaccination or infection was not associated with ASD risk in offspring. The findings support recommendations to vaccinate pregnant women to protect themselves and their infants, both of whom are vulnerable to severe morbidity following infection.
Keywords: Autism; Infection; Influenza; Pregnancy; Vaccine.
. 2022 Feb 17;ciac101.
doi: 10.1093/cid/ciac101. Online ahead of print.
Prenatal influenza vaccination or influenza infection and autism spectrum disorder in offspring
Tracy A Becerra-Culqui[SUP] 1 2 [/SUP], Darios Getahun[SUP] 1 3 [/SUP], Vicki Chiu[SUP] 1 [/SUP], Lina S Sy[SUP] 1 [/SUP], Hung Fu Tseng[SUP] 1 3 [/SUP]
Affiliations
- PMID: 35174388
- DOI: 10.1093/cid/ciac101
Abstract
Background: As prenatal vaccinations continue to be given more frequently, it is important to assess long-term safety events. This study investigates the association between prenatal influenza vaccination or infection and autism spectrum disorder (ASD) risk in offspring.
Methods: Retrospective cohort study of mother-child pairs with deliveries 1/1/2011-12/31/2014 at Kaiser Permanente Southern California was performed. Children >1 year were followed through 12/31/2018. Maternal influenza vaccination or infection during pregnancy was obtained from electronic health records. ASD was defined by International Classification of Diseases, 9th/10th Revision codes after age 1 year. Cox proportional hazards models estimated the crude and inverse probability of treatment weighted (IPTW) hazard ratios (HR) for the association between maternal influenza vaccination or infection and ASD.
Results: There were 84,739 mother-child pairs included in the final analytic sample. Maternal vaccination coverage increased slightly over time, from 52.7% for 2011 births to 59.6% for 2014 births. Of the 46,257 women vaccinated, 32.4% were vaccinated during the 1 st trimester, 41.8% during the 2 nd trimester, and 25.8% during the 3 rd trimester. ASD was diagnosed in 1,930 (2.3%) children. The IPTW analyses showed no association between prenatal influenza vaccination or infection and ASD in offspring (HR: 1.04, 95% confidence interval [CI]: 0.95, 1.13; HR: 1.12, 95% CI: 0.66, 1.89, respectively).
Conclusions: Prenatal influenza vaccination or infection was not associated with ASD risk in offspring. The findings support recommendations to vaccinate pregnant women to protect themselves and their infants, both of whom are vulnerable to severe morbidity following infection.
Keywords: Autism; Infection; Influenza; Pregnancy; Vaccine.