tetano
Editor, Senior Moderator
Clin Immunol
. 2020 Aug 28;108576.
doi: 10.1016/j.clim.2020.108576. Online ahead of print.
Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients
Mar?a Caridad Montalvo Villalba[SUP] 1 [/SUP], Odalys Vald?s Ramirez[SUP] 2 [/SUP], Mayra Mun? Jim?nez[SUP] 2 [/SUP], Amely Arencibia Garcia[SUP] 2 [/SUP], Javier Martinez Alfonso[SUP] 2 [/SUP], Guelsy Gonz?lez Baez[SUP] 2 [/SUP], Rosmery Roque Arrieta[SUP] 2 [/SUP], Dianelvys Rosell Sim?n[SUP] 2 [/SUP], Delmis Alv?rez Gainza[SUP] 3 [/SUP], Beatriz Sierra Vazquez[SUP] 2 [/SUP], Sonia Resik Aguirre[SUP] 2 [/SUP], Maria Guadalupe Guzm?n Tirado[SUP] 2 [/SUP]
Affiliations
Abstract
Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0,0393). IFN-γ expression was increased in symptomatic patients (p = 0,0165). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0,0001; p = 0,0011, respectively). A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0,61, p = 0,0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection.
Keywords: COVID-19; Immunopathogenesis; Interferon gamma (IFN-γ); RANTES; SARS-CoV-2; Transformer growth factor beta 1 (TGF-β1).
. 2020 Aug 28;108576.
doi: 10.1016/j.clim.2020.108576. Online ahead of print.
Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients
Mar?a Caridad Montalvo Villalba[SUP] 1 [/SUP], Odalys Vald?s Ramirez[SUP] 2 [/SUP], Mayra Mun? Jim?nez[SUP] 2 [/SUP], Amely Arencibia Garcia[SUP] 2 [/SUP], Javier Martinez Alfonso[SUP] 2 [/SUP], Guelsy Gonz?lez Baez[SUP] 2 [/SUP], Rosmery Roque Arrieta[SUP] 2 [/SUP], Dianelvys Rosell Sim?n[SUP] 2 [/SUP], Delmis Alv?rez Gainza[SUP] 3 [/SUP], Beatriz Sierra Vazquez[SUP] 2 [/SUP], Sonia Resik Aguirre[SUP] 2 [/SUP], Maria Guadalupe Guzm?n Tirado[SUP] 2 [/SUP]
Affiliations
- PMID: 32866645
- DOI: 10.1016/j.clim.2020.108576
Abstract
Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0,0393). IFN-γ expression was increased in symptomatic patients (p = 0,0165). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0,0001; p = 0,0011, respectively). A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0,61, p = 0,0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection.
Keywords: COVID-19; Immunopathogenesis; Interferon gamma (IFN-γ); RANTES; SARS-CoV-2; Transformer growth factor beta 1 (TGF-β1).