tetano
Editor, Senior Moderator
Clin Exp Med
. 2024 Apr 23;24(1):81.
doi: 10.1007/s10238-024-01345-9. Does the SARS-CoV-2 mRNA vaccine and its serum IgG levels affect fertility treatments and obstetric outcomes? An observational cohort study
Netanella Danielli Miller[SUP] 1 2 [/SUP], Nitzan Goren Gepstein[SUP] 3 4 [/SUP], Dovev Cohen[SUP] 3 4 [/SUP], Einat Haikin Herzberger[SUP] 3 4 [/SUP], Hila Shalev Ram[SUP] 3 4 [/SUP], Jordana Mashiach Friedler[SUP] 3 4 [/SUP], Maya Sharon Weiner[SUP] 3 4 [/SUP], Roni Rahav[SUP] 3 4 [/SUP], Victoria Indenbaum[SUP] 5 [/SUP], Yaniv Lustig[SUP] 5 [/SUP], Amir Wiser[SUP] 3 4 [/SUP]
Affiliations
Background: Although there are some data regarding the COVID-19 vaccine and in in vitro fertilization (IVF) treatments, its potential impact in terms of serum immunoglobulin G (IgG) levels has not been evaluated prospectively. This study aimed to assess the effect of COVID-19 vaccine and IgG levels on IVF outcomes.
Methods: This observational, cohort study was conducted at a referral IVF unit. Couples undergoing IVF treatment during the COVID-19 vaccination period were recruited from March-April 2021. The study compared 38 women who had received the Pfizer mRNA COVID-19 vaccination to 10 women who had not and were not infected by the virus. We also compared pre- and post-vaccination IVF treatments for 24 women. The relation between serologic titers and IVF treatment outcomes was also assessed.
Results: No significant difference was found between the vaccinated and unvaccinated/uninfected groups regarding the main outcome measures. However, there was a trend toward a higher pregnancy rate for the unvaccinated group (57% vs. 23%, p = 0.078) but no difference in delivery rate (p = 0.236), gestational week (p = 0.537) or birth rate (p = 0.671).
Conclusion: We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.
Keywords: Corona virus; In vitro fertilization; Semen; mRNA COVID-19 vaccine.
. 2024 Apr 23;24(1):81.
doi: 10.1007/s10238-024-01345-9. Does the SARS-CoV-2 mRNA vaccine and its serum IgG levels affect fertility treatments and obstetric outcomes? An observational cohort study
Netanella Danielli Miller[SUP] 1 2 [/SUP], Nitzan Goren Gepstein[SUP] 3 4 [/SUP], Dovev Cohen[SUP] 3 4 [/SUP], Einat Haikin Herzberger[SUP] 3 4 [/SUP], Hila Shalev Ram[SUP] 3 4 [/SUP], Jordana Mashiach Friedler[SUP] 3 4 [/SUP], Maya Sharon Weiner[SUP] 3 4 [/SUP], Roni Rahav[SUP] 3 4 [/SUP], Victoria Indenbaum[SUP] 5 [/SUP], Yaniv Lustig[SUP] 5 [/SUP], Amir Wiser[SUP] 3 4 [/SUP]
Affiliations
- PMID: 38653875
- PMCID: PMC11039503
- DOI: 10.1007/s10238-024-01345-9
Background: Although there are some data regarding the COVID-19 vaccine and in in vitro fertilization (IVF) treatments, its potential impact in terms of serum immunoglobulin G (IgG) levels has not been evaluated prospectively. This study aimed to assess the effect of COVID-19 vaccine and IgG levels on IVF outcomes.
Methods: This observational, cohort study was conducted at a referral IVF unit. Couples undergoing IVF treatment during the COVID-19 vaccination period were recruited from March-April 2021. The study compared 38 women who had received the Pfizer mRNA COVID-19 vaccination to 10 women who had not and were not infected by the virus. We also compared pre- and post-vaccination IVF treatments for 24 women. The relation between serologic titers and IVF treatment outcomes was also assessed.
Results: No significant difference was found between the vaccinated and unvaccinated/uninfected groups regarding the main outcome measures. However, there was a trend toward a higher pregnancy rate for the unvaccinated group (57% vs. 23%, p = 0.078) but no difference in delivery rate (p = 0.236), gestational week (p = 0.537) or birth rate (p = 0.671).
Conclusion: We cautiously state that the COVID-19 mRNA vaccine does not affect fertility outcomes, including fertilization, pregnancy and delivery rates, obstetric outcomes, and semen parameters, regardless of measured IgG levels.
Keywords: Corona virus; In vitro fertilization; Semen; mRNA COVID-19 vaccine.