tetano
Editor, Senior Moderator
Clin Case Rep
. 2026 Mar 19;14(3):e72335.
doi: 10.1002/ccr3.72335. eCollection 2026 Mar.
Recurrent Cytopathic Effects and Prolonged Viral Shedding in an Immunocompromised Patient With Malignant Lymphoma Treated With Rituximab and Bendamustine: A Case of Coronavirus Disease 2019 Relapse
Takahisa Ohira[SUP] 1 [/SUP], Taku Ogawa[SUP] 1 2 [/SUP], Tomoko Tanaka[SUP] 1 [/SUP], Shoichi Sakaguchi[SUP] 2 [/SUP], Youichi Suzuki[SUP] 2 [/SUP], Hong Wu[SUP] 2 [/SUP], Tomoyuki Yamada[SUP] 1 2 [/SUP], Yuriko Shibata[SUP] 1 [/SUP], Kazuki Iwaki[SUP] 3 [/SUP], Ayana Okazaki[SUP] 4 [/SUP], Akira Ukimura[SUP] 1 [/SUP], Takashi Nakano[SUP] 1 2 [/SUP]
Affiliations
A 79-year-old woman with malignant lymphoma initially recovered from mild coronavirus disease 2019 (COVID-19), but later developed pneumonia. Despite continuous PCR positivity, cytopathic effect (CPE) temporarily became negative before re-emerging with clinical deterioration. This case shows that PCR results alone cannot reliably determine viral infectivity, and once-negative CPE can become positive again.
Keywords: COVID‐19; cytopathic effect; immunocompromised; malignant lymphoma; relapse.
. 2026 Mar 19;14(3):e72335.
doi: 10.1002/ccr3.72335. eCollection 2026 Mar.
Recurrent Cytopathic Effects and Prolonged Viral Shedding in an Immunocompromised Patient With Malignant Lymphoma Treated With Rituximab and Bendamustine: A Case of Coronavirus Disease 2019 Relapse
Takahisa Ohira[SUP] 1 [/SUP], Taku Ogawa[SUP] 1 2 [/SUP], Tomoko Tanaka[SUP] 1 [/SUP], Shoichi Sakaguchi[SUP] 2 [/SUP], Youichi Suzuki[SUP] 2 [/SUP], Hong Wu[SUP] 2 [/SUP], Tomoyuki Yamada[SUP] 1 2 [/SUP], Yuriko Shibata[SUP] 1 [/SUP], Kazuki Iwaki[SUP] 3 [/SUP], Ayana Okazaki[SUP] 4 [/SUP], Akira Ukimura[SUP] 1 [/SUP], Takashi Nakano[SUP] 1 2 [/SUP]
Affiliations
- PMID: 42016624
- PMCID: PMC13093559
- DOI: 10.1002/ccr3.72335
A 79-year-old woman with malignant lymphoma initially recovered from mild coronavirus disease 2019 (COVID-19), but later developed pneumonia. Despite continuous PCR positivity, cytopathic effect (CPE) temporarily became negative before re-emerging with clinical deterioration. This case shows that PCR results alone cannot reliably determine viral infectivity, and once-negative CPE can become positive again.
Keywords: COVID‐19; cytopathic effect; immunocompromised; malignant lymphoma; relapse.