tetano
Editor, Senior Moderator
Clin Appl Thromb Hemost
. 2023 Jan-Dec;29:10760296231175656.
doi: 10.1177/10760296231175656. Thrombosis Occurrence in COVID-19 Compared With Other Infectious Causes of ARDS: A Contemporary Cohort
Andréa Coy-Canguçu[SUP] 1 [/SUP], Gisele A Locachevic[SUP] 2 [/SUP], João Carlos S Mariolano[SUP] 2 [/SUP], Kaio Henrique De O Soares[SUP] 2 [/SUP], José Diogo Oliveira[SUP] 3 [/SUP], Camila De Oliveira Vaz[SUP] 3 [/SUP], Gislaine Vieira-Damiani[SUP] 4 [/SUP], Bruna Mazetto[SUP] 3 [/SUP], Joyce Maria Annichino-Bizzacchi[SUP] 3 5 [/SUP], Erich V De Paula[SUP] 3 5 [/SUP], Fernanda A Orsi[SUP] 2 [/SUP]
Affiliations
Thrombosis occurrence in coronavirus disease 2019 (COVID-19) has been mostly compared to historical cohorts of patients with other respiratory infections. We retrospectively evaluated the thrombotic events that occurred in a contemporary cohort of patients hospitalized between March and July 2020 for acute respiratory distress syndrome (ARDS) according to the Berlin Definition and compared those with positive and negative real-time polymerase chain reaction results for wild-type severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) using descriptive analysis. The association between COVID-19 and thrombotic risk was evaluated using logistic regression. 264 COVID-19-positive (56.8% male, 59.0 years [IQR 48.6-69.7], Padua score on admission 3.0 [2.0-3.0]) and 88 COVID-19-negative patients (58.0% male, 63.7 years [51.2-73.5], Padua score 3.0 [2.0-5.0]) were included. 10.2% of non-COVID-19 and 8.7% of COVID-19 patients presented≥1 clinically relevant thrombotic event confirmed by imaging exam. After adjustment for sex, Padua score, intensive care unit stay, thromboprophylaxis, and hospitalization length, the odds ratio for thrombosis in COVID-19 was 0.69 (95% CI, 0.30-1.64). We, therefore, conclude that infection-induced ARDS carries an inherent thrombotic risk, which was comparable between patients with COVID-19 and other respiratory infections in our contemporary cohort.
Keywords: COVID-19; deep venous thrombosis; hypercoagulation; infection; pulmonary embolism; thrombosis.
. 2023 Jan-Dec;29:10760296231175656.
doi: 10.1177/10760296231175656. Thrombosis Occurrence in COVID-19 Compared With Other Infectious Causes of ARDS: A Contemporary Cohort
Andréa Coy-Canguçu[SUP] 1 [/SUP], Gisele A Locachevic[SUP] 2 [/SUP], João Carlos S Mariolano[SUP] 2 [/SUP], Kaio Henrique De O Soares[SUP] 2 [/SUP], José Diogo Oliveira[SUP] 3 [/SUP], Camila De Oliveira Vaz[SUP] 3 [/SUP], Gislaine Vieira-Damiani[SUP] 4 [/SUP], Bruna Mazetto[SUP] 3 [/SUP], Joyce Maria Annichino-Bizzacchi[SUP] 3 5 [/SUP], Erich V De Paula[SUP] 3 5 [/SUP], Fernanda A Orsi[SUP] 2 [/SUP]
Affiliations
- PMID: 37203167
- DOI: 10.1177/10760296231175656
Thrombosis occurrence in coronavirus disease 2019 (COVID-19) has been mostly compared to historical cohorts of patients with other respiratory infections. We retrospectively evaluated the thrombotic events that occurred in a contemporary cohort of patients hospitalized between March and July 2020 for acute respiratory distress syndrome (ARDS) according to the Berlin Definition and compared those with positive and negative real-time polymerase chain reaction results for wild-type severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) using descriptive analysis. The association between COVID-19 and thrombotic risk was evaluated using logistic regression. 264 COVID-19-positive (56.8% male, 59.0 years [IQR 48.6-69.7], Padua score on admission 3.0 [2.0-3.0]) and 88 COVID-19-negative patients (58.0% male, 63.7 years [51.2-73.5], Padua score 3.0 [2.0-5.0]) were included. 10.2% of non-COVID-19 and 8.7% of COVID-19 patients presented≥1 clinically relevant thrombotic event confirmed by imaging exam. After adjustment for sex, Padua score, intensive care unit stay, thromboprophylaxis, and hospitalization length, the odds ratio for thrombosis in COVID-19 was 0.69 (95% CI, 0.30-1.64). We, therefore, conclude that infection-induced ARDS carries an inherent thrombotic risk, which was comparable between patients with COVID-19 and other respiratory infections in our contemporary cohort.
Keywords: COVID-19; deep venous thrombosis; hypercoagulation; infection; pulmonary embolism; thrombosis.