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Psychiatric conditions linked to more COVID-19 hospital stays
News brief
Today at 1:27 p.m.
Stephanie Soucheray, MA
Topics
COVID-19
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A new analysis of data in Influenza and Other Respiratory Viruses finds that the incidence of COVID-19 hospitalization is more than double among patients with any psychiatric disorder compared to adults with no psychiatric disorder.
The longitudinal study is based on electronic health records collected from four health systems and research centers in Indiana, Oregon, Texas, and Utah that partner with the Centers for Disease Control and Prevention (CDC). The study follow-up period lasted from December 2021 to August 2022, after both widespread vaccination campaigns and the Omicron variant became features of the pandemic in the United States.
Among the 2,436,999 adults included in the study, the median age was 47. Women composed 58.3% of the sample, 66.1% were White, 12.9% were Black, 12.0% were Hispanic, and 3.6% were Asian. Among participants, 41.6% were unvaccinated, 35.7% had received two doses, and 22.7% had received three doses.
Anxiety, mood disorders tied to hospitalization
A total of 538,034 adults had any psychiatric disorder, including 13.6% with anxiety disorders, 12.9% with mood disorders, 3.1% with trauma or stressor-related disorders, 1.9% with attention-deficit hyperactivity disorders, and 1.0% with psychotic disorders.
Adults with psychiatric disorders were hospitalized at a rate of 394 per 100,000 person-years, compared with a rate of 156 per 100,000 person-years for those without psychiatric disorder.
Psychiatric disorder was a significant predictor of COVID-19-associated hospitalization (adjusted hazard ratio, 1.27; 95% confidence interval, 1.18 to 1.37). Mood disorders, anxiety, and psychotic disorders were most associated with hospitalization.
Adjusted hazard ratios for hospitalization among vaccinated and unvaccinated adults with or without psychiatric disorders was the same.
The relative protection associated with mRNA vaccination was similar irrespective of psychiatric disorder status.
"The relative protection associated with mRNA vaccination was similar irrespective of psychiatric disorder status, underscoring the benefit of COVID-19 vaccination in this population," the authors concluded.
Full COVID vaccination tied to lower risk of heart conditions, death
News brief
Today at 12:17 p.m.
Mary Van Beusekom, MS
Topics
COVID-19
Partially vaccinated or unvaccinated COVID-19 patients in California were at significantly higher risk for related non-respiratory consequences such as fever and abnormally rapid heart rate, as well as death in certain variant periods, a team led by University of California (UC) Irvine researchers reports in Vaccine.
The team conducted a longitudinal retrospective review of the electronic medical records of 63,454 UC COVID-19 patients of any age or hospitalization status to determine rates of non-respiratory symptoms, vaccination status, and death by 30 days after diagnosis by variant period from January 2020 to April 2022. The study period spanned the predominance of the wild-type, Alpha, Delta, and Omicron variants; vaccines were available to most people starting in the Delta wave.
Full vaccination was considered the receipt of at least two COVID-19 vaccine doses. Of all patients, 12.3% were fully vaccinated, and 87.6% had received one or no dose.
Vaccine protected against death even in younger people
Rates of fever, the most common symptom across all variant periods, were significantly higher among partially vaccinated or unvaccinated than in fully vaccinated patients during the Delta and Omicron waves.
Cardiac conditions were significantly more common in those not fully vaccinated amid Omicron, and tachycardia (abnormally rapid heart rate) occurred only in this group during Delta and Omicron. High blood pressure was the most common cardiac feature, regardless of variant period or vaccination status.
Our findings reveal distinct features of each wave and a significant association of most features with vaccination status.
Partially vaccinated and unvaccinated patients were at significantly higher risk for death in the Delta and Omicron periods (Delta odds ratio [OR], 1.64); Omicron OR, 1.96). Diabetes and gastrointestinal reflux disease were reported during all variant periods, regardless of vaccination status.
"Our findings reveal distinct features of each wave and a significant association of most features with vaccination status," the researchers wrote. "Although Omicron was shown to affect mostly younger people, the risk of death was still higher in the unvaccinated population, and thus the vaccine provided some protection from COVID-19 even among younger individuals."
ALL BRIEFS
Psychiatric conditions linked to more COVID-19 hospital stays
News brief
Today at 1:27 p.m.
Stephanie Soucheray, MA
Topics
COVID-19
SHARE
A new analysis of data in Influenza and Other Respiratory Viruses finds that the incidence of COVID-19 hospitalization is more than double among patients with any psychiatric disorder compared to adults with no psychiatric disorder.
The longitudinal study is based on electronic health records collected from four health systems and research centers in Indiana, Oregon, Texas, and Utah that partner with the Centers for Disease Control and Prevention (CDC). The study follow-up period lasted from December 2021 to August 2022, after both widespread vaccination campaigns and the Omicron variant became features of the pandemic in the United States.
Among the 2,436,999 adults included in the study, the median age was 47. Women composed 58.3% of the sample, 66.1% were White, 12.9% were Black, 12.0% were Hispanic, and 3.6% were Asian. Among participants, 41.6% were unvaccinated, 35.7% had received two doses, and 22.7% had received three doses.
Anxiety, mood disorders tied to hospitalization
A total of 538,034 adults had any psychiatric disorder, including 13.6% with anxiety disorders, 12.9% with mood disorders, 3.1% with trauma or stressor-related disorders, 1.9% with attention-deficit hyperactivity disorders, and 1.0% with psychotic disorders.
Adults with psychiatric disorders were hospitalized at a rate of 394 per 100,000 person-years, compared with a rate of 156 per 100,000 person-years for those without psychiatric disorder.
Psychiatric disorder was a significant predictor of COVID-19-associated hospitalization (adjusted hazard ratio, 1.27; 95% confidence interval, 1.18 to 1.37). Mood disorders, anxiety, and psychotic disorders were most associated with hospitalization.
Adjusted hazard ratios for hospitalization among vaccinated and unvaccinated adults with or without psychiatric disorders was the same.
The relative protection associated with mRNA vaccination was similar irrespective of psychiatric disorder status.
"The relative protection associated with mRNA vaccination was similar irrespective of psychiatric disorder status, underscoring the benefit of COVID-19 vaccination in this population," the authors concluded.
Full COVID vaccination tied to lower risk of heart conditions, death
News brief
Today at 12:17 p.m.
Mary Van Beusekom, MS
Topics
COVID-19
Partially vaccinated or unvaccinated COVID-19 patients in California were at significantly higher risk for related non-respiratory consequences such as fever and abnormally rapid heart rate, as well as death in certain variant periods, a team led by University of California (UC) Irvine researchers reports in Vaccine.
The team conducted a longitudinal retrospective review of the electronic medical records of 63,454 UC COVID-19 patients of any age or hospitalization status to determine rates of non-respiratory symptoms, vaccination status, and death by 30 days after diagnosis by variant period from January 2020 to April 2022. The study period spanned the predominance of the wild-type, Alpha, Delta, and Omicron variants; vaccines were available to most people starting in the Delta wave.
Full vaccination was considered the receipt of at least two COVID-19 vaccine doses. Of all patients, 12.3% were fully vaccinated, and 87.6% had received one or no dose.
Vaccine protected against death even in younger people
Rates of fever, the most common symptom across all variant periods, were significantly higher among partially vaccinated or unvaccinated than in fully vaccinated patients during the Delta and Omicron waves.
Cardiac conditions were significantly more common in those not fully vaccinated amid Omicron, and tachycardia (abnormally rapid heart rate) occurred only in this group during Delta and Omicron. High blood pressure was the most common cardiac feature, regardless of variant period or vaccination status.
Our findings reveal distinct features of each wave and a significant association of most features with vaccination status.
Partially vaccinated and unvaccinated patients were at significantly higher risk for death in the Delta and Omicron periods (Delta odds ratio [OR], 1.64); Omicron OR, 1.96). Diabetes and gastrointestinal reflux disease were reported during all variant periods, regardless of vaccination status.
"Our findings reveal distinct features of each wave and a significant association of most features with vaccination status," the researchers wrote. "Although Omicron was shown to affect mostly younger people, the risk of death was still higher in the unvaccinated population, and thus the vaccine provided some protection from COVID-19 even among younger individuals."
ALL BRIEFS