Characterization of three clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated from wild birds

[tetano]

J Infect. 2019 Mar 27. pii: S0163-4453(19)30096-9. doi: 10.1016/j.jinf.2019.03.011. [Epub ahead of print]
[h=1]Characterization of three clade 2.3.4.4 H5 highly pathogenic avian influenza viruses isolated from wild birds.[/h] Qiu Y[SUP]1[/SUP], Li Y[SUP]2[/SUP], Li J[SUP]2[/SUP], Hou G[SUP]2[/SUP], Wang S[SUP]2[/SUP], Zhuang Q[SUP]2[/SUP], Peng C[SUP]2[/SUP], Zhao X[SUP]1[/SUP], Jiang W[SUP]3[/SUP], Zou F[SUP]4[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] We isolated and characterized three H5 HPAIVs with different NA subtypes (N1, N6 and N8) during avian influenza virus (AIV) surveillance in wild birds during 2015-2016. The P126/H5N1, P560/H5N6 and ST/H5N8 viruses were highly pathogenic to chickens and ducks. Furthermore, P126/H5N1 and P560/H5N6 showed high pathogenicity in mice. Continued circulation of these influenza virus strains clearly poses a significant potential health threat to poultry and human populations.
Copyright ? 2019. Published by Elsevier Ltd.


[h=4]KEYWORDS:[/h] Chickens; Ducks; H5; Highly pathogenic; Mice; Pathogenicity

PMID: 30928558 DOI: 10.1016/j.jinf.2019.03.011