tetano
Editor, Senior Moderator
Microorganisms. 2019 Dec 3;7(12). pii: E643. doi: 10.3390/microorganisms7120643. [h=1]Characterization and Phylodynamics of Reassortant H12Nx Viruses in Northern Eurasia.[/h]
Sharshov K[SUP]1[/SUP], Mine J[SUP]2[/SUP], Sobolev I[SUP]1[/SUP], Kurskaya O[SUP]1[/SUP], Dubovitskiy N[SUP]1[/SUP], Kabilov M[SUP]3[/SUP], Alikina T[SUP]3[/SUP], Nakayama M[SUP]2[/SUP], Tsunekuni R[SUP]2[/SUP], Derko A[SUP]1[/SUP], Prokopyeva E[SUP]1[/SUP], Alekseev A[SUP]1[/SUP], Shchelkanov M[SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Druzyaka A[SUP]7[/SUP], Gadzhiev A[SUP]8[/SUP], Uchida Y[SUP]2[/SUP], Shestopalov A[SUP]1[/SUP], Saito T[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Experimental Modeling and Pathogenesis of Infectious Diseases, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630117, Russia. 2 Division of Transboundary Animal Disease, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. 3 Genomics Core Facility, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia. 4 School of Biomedicine, Far Eastern Federal University, Vladivostok 690091, Russia. 5 Laboratory of Virology, Federal Scientific Center of East Asia Terrestrial Biodiversity, Vladivostok 690022, Russia. 6 Laboratory of marine microbiota, National Scientific Center o Marine Biology, Vladivostok, Vladivostok 690041, Russia. 7 Laboratory of behavioral ecology, Institute of Animal Systematics and Ecology, Novosibirsk 630091, Russia. 8 Department of ecology, Dagestan State University, Makhachkala 367000, Russia.
[h=3]Abstract[/h] Wild waterfowl birds are known to be the main reservoir for a variety of avian influenza viruses of different subtypes. Some subtypes, such as H2Nx, H8Nx, H12Nx, and H14Nx, occur relatively rarely in nature. During 10-year long-term surveillance, we isolated five rare H12N5 and one H12N2 viruses in three different distinct geographic regions of Northern Eurasia and studied their characteristics. H12N2 from the Far East region was a double reassortant containing hemagglutinin (HA), non-structural (NS) and nucleoprotein (NP) segments of the American lineage and others from the classical Eurasian avian-like lineage. H12N5 viruses contain Eurasian lineage segments. We suggest a phylogeographical scheme for reassortment events associated with geographical groups of aquatic birds and their migration flyways. The H12N2 virus is of particular interest as this subtype has been found in common teal in the Russian Far East region, and it has a strong relation to North American avian influenza virus lineages, clearly showing that viral exchange of segments between the two continents does occur. Our results emphasize the importance of Avian Influenza Virus (AIV) surveillance in Northern Eurasia for the annual screening of virus characteristics, including the genetic constellation of rare virus subtypes, to understand the evolutionary ecology of AIV.
[h=4]KEYWORDS:[/h] American lineage; H12Nx; Northern Eurasia; avian influenza; multiple reassortant; rare subtype; wild birds
PMID: 31816947 DOI: 10.3390/microorganisms7120643
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Sharshov K[SUP]1[/SUP], Mine J[SUP]2[/SUP], Sobolev I[SUP]1[/SUP], Kurskaya O[SUP]1[/SUP], Dubovitskiy N[SUP]1[/SUP], Kabilov M[SUP]3[/SUP], Alikina T[SUP]3[/SUP], Nakayama M[SUP]2[/SUP], Tsunekuni R[SUP]2[/SUP], Derko A[SUP]1[/SUP], Prokopyeva E[SUP]1[/SUP], Alekseev A[SUP]1[/SUP], Shchelkanov M[SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Druzyaka A[SUP]7[/SUP], Gadzhiev A[SUP]8[/SUP], Uchida Y[SUP]2[/SUP], Shestopalov A[SUP]1[/SUP], Saito T[SUP]2[/SUP].
[h=3]Author information[/h] 1 Department of Experimental Modeling and Pathogenesis of Infectious Diseases, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630117, Russia. 2 Division of Transboundary Animal Disease, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan. 3 Genomics Core Facility, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia. 4 School of Biomedicine, Far Eastern Federal University, Vladivostok 690091, Russia. 5 Laboratory of Virology, Federal Scientific Center of East Asia Terrestrial Biodiversity, Vladivostok 690022, Russia. 6 Laboratory of marine microbiota, National Scientific Center o Marine Biology, Vladivostok, Vladivostok 690041, Russia. 7 Laboratory of behavioral ecology, Institute of Animal Systematics and Ecology, Novosibirsk 630091, Russia. 8 Department of ecology, Dagestan State University, Makhachkala 367000, Russia.
[h=3]Abstract[/h] Wild waterfowl birds are known to be the main reservoir for a variety of avian influenza viruses of different subtypes. Some subtypes, such as H2Nx, H8Nx, H12Nx, and H14Nx, occur relatively rarely in nature. During 10-year long-term surveillance, we isolated five rare H12N5 and one H12N2 viruses in three different distinct geographic regions of Northern Eurasia and studied their characteristics. H12N2 from the Far East region was a double reassortant containing hemagglutinin (HA), non-structural (NS) and nucleoprotein (NP) segments of the American lineage and others from the classical Eurasian avian-like lineage. H12N5 viruses contain Eurasian lineage segments. We suggest a phylogeographical scheme for reassortment events associated with geographical groups of aquatic birds and their migration flyways. The H12N2 virus is of particular interest as this subtype has been found in common teal in the Russian Far East region, and it has a strong relation to North American avian influenza virus lineages, clearly showing that viral exchange of segments between the two continents does occur. Our results emphasize the importance of Avian Influenza Virus (AIV) surveillance in Northern Eurasia for the annual screening of virus characteristics, including the genetic constellation of rare virus subtypes, to understand the evolutionary ecology of AIV.
[h=4]KEYWORDS:[/h] American lineage; H12Nx; Northern Eurasia; avian influenza; multiple reassortant; rare subtype; wild birds
PMID: 31816947 DOI: 10.3390/microorganisms7120643
Free full text