tetano
Editor, Senior Moderator
Curr Opin Virol. 2014 Aug 7;8C:85-89. doi: 10.1016/j.coviro.2014.07.007. [Epub ahead of print]
Challenges of selecting seasonal influenza vaccine strains for humans with diverse pre-exposure histories.
Hensley SE.
Author information
Abstract
Seasonal influenza vaccine strains are routinely updated when influenza viruses acquire mutations in exposed regions of the hemagglutinin and neuraminidase glycoproteins. Ironically, although thousands of viral isolates are sequenced each year, today's influenza surveillance community places less emphasis on viral genetic information and more emphasis on classical serological assays when choosing vaccine strains. Here, I argue that these classical serological assays are oversimplified and that they fail to detect influenza mutations that facilitate escape of particular types of human antibodies. I propose that influenza vaccine strains should be updated more frequently even when classical serological assays fail to detect significant antigenic alterations.
Copyright ? 2014 Elsevier B.V. All rights reserved.
PMID:
25108824
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25108824
Challenges of selecting seasonal influenza vaccine strains for humans with diverse pre-exposure histories.
Hensley SE.
Author information
Abstract
Seasonal influenza vaccine strains are routinely updated when influenza viruses acquire mutations in exposed regions of the hemagglutinin and neuraminidase glycoproteins. Ironically, although thousands of viral isolates are sequenced each year, today's influenza surveillance community places less emphasis on viral genetic information and more emphasis on classical serological assays when choosing vaccine strains. Here, I argue that these classical serological assays are oversimplified and that they fail to detect influenza mutations that facilitate escape of particular types of human antibodies. I propose that influenza vaccine strains should be updated more frequently even when classical serological assays fail to detect significant antigenic alterations.
Copyright ? 2014 Elsevier B.V. All rights reserved.
PMID:
25108824
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25108824