tetano
Editor, Senior Moderator
CEN Case Rep
. 2022 Oct 11.
doi: 10.1007/s13730-022-00743-w. Online ahead of print.
Comparison of renal histopathology in three patients with gross hematuria after SARS-CoV-2 vaccination
Kento Ota[SUP] 1 [/SUP], Yuriko Yonekura[SUP] 2 [/SUP], Madoka Saigan[SUP] 1 [/SUP], Kimihiko Goto[SUP] 1 [/SUP], Shinichi Nishi[SUP] 3 [/SUP]
Affiliations
Abstract
We present three cases of IgA nephropathy with gross hematuria following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination. Case 1 was a 60-year-old woman who has previously experienced transient proteinuria. Case 2 was a 22-year-old woman with no history of urinary abnormality. Finally, case 3 was a 66-year-old woman who has had microscopic hematuria since she was in her 50s. They were all diagnosed as IgA nephropathy with little histological active lesion. Their renal function and proteinuria improved without the use of corticosteroids. There were differences in the findings of vascular endothelial damage based on the time between the appearance of gross hematuria and renal biopsy. Glomerular endocapillary damage could be a part of the mechanism triggered by mRNA vaccination. When a patient presents with gross hematuria following vaccination, a comprehensive approach including renal biopsy should be considered.
Keywords: Gross hematuria; IgA nephropathy; SARS-CoV-2 vaccine.
. 2022 Oct 11.
doi: 10.1007/s13730-022-00743-w. Online ahead of print.
Comparison of renal histopathology in three patients with gross hematuria after SARS-CoV-2 vaccination
Kento Ota[SUP] 1 [/SUP], Yuriko Yonekura[SUP] 2 [/SUP], Madoka Saigan[SUP] 1 [/SUP], Kimihiko Goto[SUP] 1 [/SUP], Shinichi Nishi[SUP] 3 [/SUP]
Affiliations
- PMID: 36219335
- DOI: 10.1007/s13730-022-00743-w
Abstract
We present three cases of IgA nephropathy with gross hematuria following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccination. Case 1 was a 60-year-old woman who has previously experienced transient proteinuria. Case 2 was a 22-year-old woman with no history of urinary abnormality. Finally, case 3 was a 66-year-old woman who has had microscopic hematuria since she was in her 50s. They were all diagnosed as IgA nephropathy with little histological active lesion. Their renal function and proteinuria improved without the use of corticosteroids. There were differences in the findings of vascular endothelial damage based on the time between the appearance of gross hematuria and renal biopsy. Glomerular endocapillary damage could be a part of the mechanism triggered by mRNA vaccination. When a patient presents with gross hematuria following vaccination, a comprehensive approach including renal biopsy should be considered.
Keywords: Gross hematuria; IgA nephropathy; SARS-CoV-2 vaccine.