tetano
Editor, Senior Moderator
Cell
. 2021 Jan 26;S0092-8674(21)00078-7.
doi: 10.1016/j.cell.2021.01.035. Online ahead of print.
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Philip J M Brouwer[SUP] 1 [/SUP], Mitch Brinkkemper[SUP] 1 [/SUP], Pauline Maisonnasse[SUP] 2 [/SUP], Nathalie Dereuddre-Bosquet[SUP] 2 [/SUP], Marloes Grobben[SUP] 1 [/SUP], Mathieu Claireaux[SUP] 1 [/SUP], Marlon de Gast[SUP] 1 [/SUP], Romain Marlin[SUP] 2 [/SUP], Virginie Chesnais[SUP] 3 [/SUP], S?gol?ne Diry[SUP] 3 [/SUP], Joel D Allen[SUP] 4 [/SUP], Yasunori Watanabe[SUP] 5 [/SUP], Julia M Giezen[SUP] 1 [/SUP], Gius Kerster[SUP] 1 [/SUP], Hannah L Turner[SUP] 6 [/SUP], Karlijn van der Straten[SUP] 1 [/SUP], Cynthia A van der Linden[SUP] 1 [/SUP], Yoann Aldon[SUP] 1 [/SUP], Thibaut Naninck[SUP] 2 [/SUP], Ilja Bontjer[SUP] 1 [/SUP], Judith A Burger[SUP] 1 [/SUP], Meliawati Poniman[SUP] 1 [/SUP], Anna Z Mykytyn[SUP] 7 [/SUP], Nisreen M A Okba[SUP] 7 [/SUP], Edith E Schermer[SUP] 1 [/SUP], Marielle J van Breemen[SUP] 1 [/SUP], Rashmi Ravichandran[SUP] 8 [/SUP], Tom G Caniels[SUP] 1 [/SUP], Jelle van Schooten[SUP] 1 [/SUP], Nidhal Kahlaoui[SUP] 2 [/SUP], Vanessa Contreras[SUP] 2 [/SUP], Julien Lema?tre[SUP] 2 [/SUP], Catherine Chapon[SUP] 2 [/SUP], Rapha?l Ho Tsong Fang[SUP] 2 [/SUP], Julien Villaudy[SUP] 9 [/SUP], Kwinten Sliepen[SUP] 1 [/SUP], Yme U van der Velden[SUP] 1 [/SUP], Bart L Haagmans[SUP] 7 [/SUP], Godelieve J de Bree[SUP] 10 [/SUP], Eric Ginoux[SUP] 3 [/SUP], Andrew B Ward[SUP] 6 [/SUP], Max Crispin[SUP] 4 [/SUP], Neil P King[SUP] 8 [/SUP], Sylvie van der Werf[SUP] 11 [/SUP], Marit J van Gils[SUP] 1 [/SUP], Roger Le Grand[SUP] 12 [/SUP], Rogier W Sanders[SUP] 13 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.
Keywords: B cells; COVID-19; SARS-CoV-2; antibodies; immunity; macaques; nanoparticles; protection; vaccine.
. 2021 Jan 26;S0092-8674(21)00078-7.
doi: 10.1016/j.cell.2021.01.035. Online ahead of print.
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Philip J M Brouwer[SUP] 1 [/SUP], Mitch Brinkkemper[SUP] 1 [/SUP], Pauline Maisonnasse[SUP] 2 [/SUP], Nathalie Dereuddre-Bosquet[SUP] 2 [/SUP], Marloes Grobben[SUP] 1 [/SUP], Mathieu Claireaux[SUP] 1 [/SUP], Marlon de Gast[SUP] 1 [/SUP], Romain Marlin[SUP] 2 [/SUP], Virginie Chesnais[SUP] 3 [/SUP], S?gol?ne Diry[SUP] 3 [/SUP], Joel D Allen[SUP] 4 [/SUP], Yasunori Watanabe[SUP] 5 [/SUP], Julia M Giezen[SUP] 1 [/SUP], Gius Kerster[SUP] 1 [/SUP], Hannah L Turner[SUP] 6 [/SUP], Karlijn van der Straten[SUP] 1 [/SUP], Cynthia A van der Linden[SUP] 1 [/SUP], Yoann Aldon[SUP] 1 [/SUP], Thibaut Naninck[SUP] 2 [/SUP], Ilja Bontjer[SUP] 1 [/SUP], Judith A Burger[SUP] 1 [/SUP], Meliawati Poniman[SUP] 1 [/SUP], Anna Z Mykytyn[SUP] 7 [/SUP], Nisreen M A Okba[SUP] 7 [/SUP], Edith E Schermer[SUP] 1 [/SUP], Marielle J van Breemen[SUP] 1 [/SUP], Rashmi Ravichandran[SUP] 8 [/SUP], Tom G Caniels[SUP] 1 [/SUP], Jelle van Schooten[SUP] 1 [/SUP], Nidhal Kahlaoui[SUP] 2 [/SUP], Vanessa Contreras[SUP] 2 [/SUP], Julien Lema?tre[SUP] 2 [/SUP], Catherine Chapon[SUP] 2 [/SUP], Rapha?l Ho Tsong Fang[SUP] 2 [/SUP], Julien Villaudy[SUP] 9 [/SUP], Kwinten Sliepen[SUP] 1 [/SUP], Yme U van der Velden[SUP] 1 [/SUP], Bart L Haagmans[SUP] 7 [/SUP], Godelieve J de Bree[SUP] 10 [/SUP], Eric Ginoux[SUP] 3 [/SUP], Andrew B Ward[SUP] 6 [/SUP], Max Crispin[SUP] 4 [/SUP], Neil P King[SUP] 8 [/SUP], Sylvie van der Werf[SUP] 11 [/SUP], Marit J van Gils[SUP] 1 [/SUP], Roger Le Grand[SUP] 12 [/SUP], Rogier W Sanders[SUP] 13 [/SUP]
Affiliations
- PMID: 33577765
- PMCID: PMC7834972
- DOI: 10.1016/j.cell.2021.01.035
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.
Keywords: B cells; COVID-19; SARS-CoV-2; antibodies; immunity; macaques; nanoparticles; protection; vaccine.