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Cell Stem Cell . Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons

tetano

Editor, Senior Moderator
Cell Stem Cell


. 2024 Feb 1;31(2):152-154.
doi: 10.1016/j.stem.2024.01.002. Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons

Ilse Eidhof[SUP] 1 [/SUP], Daniel Twohig[SUP] 2 [/SUP], Anna Falk[SUP] 3 [/SUP]



Affiliations
Abstract

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.


 
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