tetano
Editor, Senior Moderator
Cell Rep
. 2024 Aug 29;43(9):114684.
doi: 10.1016/j.celrep.2024.114684. Online ahead of print. SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner
Wonyeong Jung[SUP] 1 [/SUP], Arturo Abdelnour[SUP] 2 [/SUP], Paulina Kaplonek[SUP] 3 [/SUP], Rolando Herrero[SUP] 4 [/SUP], Jessica Shih-Lu Lee[SUP] 3 [/SUP], Domenic R Barbati[SUP] 3 [/SUP], Taras M Chicz[SUP] 3 [/SUP], Kate S Levine[SUP] 3 [/SUP], Romain Clement Fantin[SUP] 4 [/SUP]; RESPIRA study group[SUP] 4 [/SUP]; Viviana Loria[SUP] 4 [/SUP], Carolina Porras[SUP] 4 [/SUP], Douglas A Lauffenburger[SUP] 5 [/SUP], Mitchell H Gail[SUP] 6 [/SUP], Amada Aparicio[SUP] 2 [/SUP], Allan Hildesheim[SUP] 4 [/SUP], Galit Alter[SUP] 7 [/SUP], Ryan P McNamara[SUP] 8 [/SUP]
Affiliations
Immunity acquired by vaccination following infection, termed hybrid immunity, has been shown to confer enhanced protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by enhancing the breadth and potency of immune responses. Here, we assess Fc-mediated humoral profiles in hybrid immunity and their association with age and vaccine type. Participants are divided into three groups: infection only, vaccination only, and vaccination following infection (i.e., hybrid immunity). Using systems serology, we profile humoral immune responses against spikes and subdomains of SARS-CoV-2 variants. We find that hybrid immunity is characterized by superior Fc receptor binding and natural killer (NK) cell-, neutrophil-, and complement-activating antibodies, which is higher than what can be expected from the sum of the vaccination and infection. These differences between hybrid immunity and vaccine-induced immunity are more pronounced in aged adults, especially for immunoglobulin (Ig)G1, IgG2, and Fcγ receptor-binding antibodies. Our findings suggest that vaccination strategies that aim to mimic hybrid immunity should consider age as an important modifier.
Keywords: CP: Immunology; antibodies; effector functions; hybrid immunity; infection; natural killer cells; vaccination.
. 2024 Aug 29;43(9):114684.
doi: 10.1016/j.celrep.2024.114684. Online ahead of print. SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner
Wonyeong Jung[SUP] 1 [/SUP], Arturo Abdelnour[SUP] 2 [/SUP], Paulina Kaplonek[SUP] 3 [/SUP], Rolando Herrero[SUP] 4 [/SUP], Jessica Shih-Lu Lee[SUP] 3 [/SUP], Domenic R Barbati[SUP] 3 [/SUP], Taras M Chicz[SUP] 3 [/SUP], Kate S Levine[SUP] 3 [/SUP], Romain Clement Fantin[SUP] 4 [/SUP]; RESPIRA study group[SUP] 4 [/SUP]; Viviana Loria[SUP] 4 [/SUP], Carolina Porras[SUP] 4 [/SUP], Douglas A Lauffenburger[SUP] 5 [/SUP], Mitchell H Gail[SUP] 6 [/SUP], Amada Aparicio[SUP] 2 [/SUP], Allan Hildesheim[SUP] 4 [/SUP], Galit Alter[SUP] 7 [/SUP], Ryan P McNamara[SUP] 8 [/SUP]
Affiliations
- PMID: 39213155
- DOI: 10.1016/j.celrep.2024.114684
Immunity acquired by vaccination following infection, termed hybrid immunity, has been shown to confer enhanced protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by enhancing the breadth and potency of immune responses. Here, we assess Fc-mediated humoral profiles in hybrid immunity and their association with age and vaccine type. Participants are divided into three groups: infection only, vaccination only, and vaccination following infection (i.e., hybrid immunity). Using systems serology, we profile humoral immune responses against spikes and subdomains of SARS-CoV-2 variants. We find that hybrid immunity is characterized by superior Fc receptor binding and natural killer (NK) cell-, neutrophil-, and complement-activating antibodies, which is higher than what can be expected from the sum of the vaccination and infection. These differences between hybrid immunity and vaccine-induced immunity are more pronounced in aged adults, especially for immunoglobulin (Ig)G1, IgG2, and Fcγ receptor-binding antibodies. Our findings suggest that vaccination strategies that aim to mimic hybrid immunity should consider age as an important modifier.
Keywords: CP: Immunology; antibodies; effector functions; hybrid immunity; infection; natural killer cells; vaccination.