tetano
Editor, Senior Moderator
Cell
. 2022 Mar 25;S0092-8674(22)00388-9.
doi: 10.1016/j.cell.2022.03.038. Online ahead of print.
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
Matthew Gagne[SUP] 1 [/SUP], Juan I Moliva[SUP] 1 [/SUP], Kathryn E Foulds[SUP] 1 [/SUP], Shayne F Andrew[SUP] 1 [/SUP], Barbara J Flynn[SUP] 1 [/SUP], Anne P Werner[SUP] 1 [/SUP], Danielle A Wagner[SUP] 1 [/SUP], I-Ting Teng[SUP] 1 [/SUP], Bob C Lin[SUP] 1 [/SUP], Christopher Moore[SUP] 1 [/SUP], Nazaire Jean-Baptiste[SUP] 1 [/SUP], Robin Carroll[SUP] 1 [/SUP], Stephanie L Foster[SUP] 2 [/SUP], Mit Patel[SUP] 2 [/SUP], Madison Ellis[SUP] 2 [/SUP], Venkata-Viswanadh Edara[SUP] 2 [/SUP], Nahara Vargas Maldonado[SUP] 2 [/SUP], Mahnaz Minai[SUP] 3 [/SUP], Lauren McCormick[SUP] 1 [/SUP], Christopher Cole Honeycutt[SUP] 1 [/SUP], Bianca M Nagata[SUP] 3 [/SUP], Kevin W Bock[SUP] 3 [/SUP], Caitlyn N M Dulan[SUP] 1 [/SUP], Jamilet Cordon[SUP] 1 [/SUP], Dillon R Flebbe[SUP] 1 [/SUP], John-Paul M Todd[SUP] 1 [/SUP], Elizabeth McCarthy[SUP] 1 [/SUP], Laurent Pessaint[SUP] 4 [/SUP], Alex Van Ry[SUP] 4 [/SUP], Brandon Narvaez[SUP] 4 [/SUP], Daniel Valentin[SUP] 4 [/SUP], Anthony Cook[SUP] 4 [/SUP], Alan Dodson[SUP] 4 [/SUP], Katelyn Steingrebe[SUP] 4 [/SUP], Saule T Nurmukhambetova[SUP] 1 [/SUP], Sucheta Godbole[SUP] 1 [/SUP], Amy R Henry[SUP] 1 [/SUP], Farida Laboune[SUP] 1 [/SUP], Jesmine Roberts-Torres[SUP] 1 [/SUP], Cynthia G Lorang[SUP] 1 [/SUP], Shivani Amin[SUP] 1 [/SUP], Jessica Trost[SUP] 1 [/SUP], Mursal Naisan[SUP] 1 [/SUP], Manjula Basappa[SUP] 1 [/SUP], Jacquelyn Willis[SUP] 1 [/SUP], Lingshu Wang[SUP] 1 [/SUP], Wei Shi[SUP] 1 [/SUP], Nicole A Doria-Rose[SUP] 1 [/SUP], Yi Zhang[SUP] 1 [/SUP], Eun Sung Yang[SUP] 1 [/SUP], Kwanyee Leung[SUP] 1 [/SUP], Sijy O'Dell[SUP] 1 [/SUP], Stephen D Schmidt[SUP] 1 [/SUP], Adam S Olia[SUP] 1 [/SUP], Cuiping Liu[SUP] 1 [/SUP], Darcy R Harris[SUP] 1 [/SUP], Gwo-Yu Chuang[SUP] 5 [/SUP], Guillaume Stewart-Jones[SUP] 5 [/SUP], Isabella Renzi[SUP] 5 [/SUP], Yen-Ting Lai[SUP] 5 [/SUP], Agata Malinowski[SUP] 5 [/SUP], Kai Wu[SUP] 5 [/SUP], John R Mascola[SUP] 1 [/SUP], Andrea Carfi[SUP] 5 [/SUP], Peter D Kwong[SUP] 1 [/SUP], Darin K Edwards[SUP] 5 [/SUP], Mark G Lewis[SUP] 4 [/SUP], Hanne Andersen[SUP] 4 [/SUP], Kizzmekia S Corbett[SUP] 6 [/SUP], Martha C Nason[SUP] 7 [/SUP], Adrian B McDermott[SUP] 1 [/SUP], Mehul S Suthar[SUP] 2 [/SUP], Ian N Moore[SUP] 8 [/SUP], Mario Roederer[SUP] 1 [/SUP], Nancy J Sullivan[SUP] 1 [/SUP], Daniel C Douek[SUP] 9 [/SUP], Robert A Seder[SUP] 10 [/SUP]
Affiliations
Abstract
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270 reciprocal ID[SUB]50[/SUB] at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for Omicron. 2 weeks after the boost, titers against D614G and Omicron increased to 5,360 and 2,980 for mRNA-1273 boost and 2,670 and 1,930 for mRNA-Omicron, respectively. Similar increases against BA.2 were observed. Following either boost, 70%-80% of spike-specific B cells were cross-reactive against WA1 and Omicron. Equivalent control of virus replication in lower airways was observed following Omicron challenge 1 month after either boost. These data show that mRNA-1273 and mRNA-Omicron elicit comparable immunity and protection shortly after the boost.
Keywords: B cells; COVID-19; Omicron; SARS-CoV-2; T cells; antibody; boost; immune memory; mRNA vaccine; original antigenic sin.
. 2022 Mar 25;S0092-8674(22)00388-9.
doi: 10.1016/j.cell.2022.03.038. Online ahead of print.
mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron
Matthew Gagne[SUP] 1 [/SUP], Juan I Moliva[SUP] 1 [/SUP], Kathryn E Foulds[SUP] 1 [/SUP], Shayne F Andrew[SUP] 1 [/SUP], Barbara J Flynn[SUP] 1 [/SUP], Anne P Werner[SUP] 1 [/SUP], Danielle A Wagner[SUP] 1 [/SUP], I-Ting Teng[SUP] 1 [/SUP], Bob C Lin[SUP] 1 [/SUP], Christopher Moore[SUP] 1 [/SUP], Nazaire Jean-Baptiste[SUP] 1 [/SUP], Robin Carroll[SUP] 1 [/SUP], Stephanie L Foster[SUP] 2 [/SUP], Mit Patel[SUP] 2 [/SUP], Madison Ellis[SUP] 2 [/SUP], Venkata-Viswanadh Edara[SUP] 2 [/SUP], Nahara Vargas Maldonado[SUP] 2 [/SUP], Mahnaz Minai[SUP] 3 [/SUP], Lauren McCormick[SUP] 1 [/SUP], Christopher Cole Honeycutt[SUP] 1 [/SUP], Bianca M Nagata[SUP] 3 [/SUP], Kevin W Bock[SUP] 3 [/SUP], Caitlyn N M Dulan[SUP] 1 [/SUP], Jamilet Cordon[SUP] 1 [/SUP], Dillon R Flebbe[SUP] 1 [/SUP], John-Paul M Todd[SUP] 1 [/SUP], Elizabeth McCarthy[SUP] 1 [/SUP], Laurent Pessaint[SUP] 4 [/SUP], Alex Van Ry[SUP] 4 [/SUP], Brandon Narvaez[SUP] 4 [/SUP], Daniel Valentin[SUP] 4 [/SUP], Anthony Cook[SUP] 4 [/SUP], Alan Dodson[SUP] 4 [/SUP], Katelyn Steingrebe[SUP] 4 [/SUP], Saule T Nurmukhambetova[SUP] 1 [/SUP], Sucheta Godbole[SUP] 1 [/SUP], Amy R Henry[SUP] 1 [/SUP], Farida Laboune[SUP] 1 [/SUP], Jesmine Roberts-Torres[SUP] 1 [/SUP], Cynthia G Lorang[SUP] 1 [/SUP], Shivani Amin[SUP] 1 [/SUP], Jessica Trost[SUP] 1 [/SUP], Mursal Naisan[SUP] 1 [/SUP], Manjula Basappa[SUP] 1 [/SUP], Jacquelyn Willis[SUP] 1 [/SUP], Lingshu Wang[SUP] 1 [/SUP], Wei Shi[SUP] 1 [/SUP], Nicole A Doria-Rose[SUP] 1 [/SUP], Yi Zhang[SUP] 1 [/SUP], Eun Sung Yang[SUP] 1 [/SUP], Kwanyee Leung[SUP] 1 [/SUP], Sijy O'Dell[SUP] 1 [/SUP], Stephen D Schmidt[SUP] 1 [/SUP], Adam S Olia[SUP] 1 [/SUP], Cuiping Liu[SUP] 1 [/SUP], Darcy R Harris[SUP] 1 [/SUP], Gwo-Yu Chuang[SUP] 5 [/SUP], Guillaume Stewart-Jones[SUP] 5 [/SUP], Isabella Renzi[SUP] 5 [/SUP], Yen-Ting Lai[SUP] 5 [/SUP], Agata Malinowski[SUP] 5 [/SUP], Kai Wu[SUP] 5 [/SUP], John R Mascola[SUP] 1 [/SUP], Andrea Carfi[SUP] 5 [/SUP], Peter D Kwong[SUP] 1 [/SUP], Darin K Edwards[SUP] 5 [/SUP], Mark G Lewis[SUP] 4 [/SUP], Hanne Andersen[SUP] 4 [/SUP], Kizzmekia S Corbett[SUP] 6 [/SUP], Martha C Nason[SUP] 7 [/SUP], Adrian B McDermott[SUP] 1 [/SUP], Mehul S Suthar[SUP] 2 [/SUP], Ian N Moore[SUP] 8 [/SUP], Mario Roederer[SUP] 1 [/SUP], Nancy J Sullivan[SUP] 1 [/SUP], Daniel C Douek[SUP] 9 [/SUP], Robert A Seder[SUP] 10 [/SUP]
Affiliations
- PMID: 35447072
- DOI: 10.1016/j.cell.2022.03.038
Abstract
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron. Neutralizing titers against D614G were 4,760 and 270 reciprocal ID[SUB]50[/SUB] at week 6 (peak) and week 41 (preboost), respectively, and 320 and 110 for Omicron. 2 weeks after the boost, titers against D614G and Omicron increased to 5,360 and 2,980 for mRNA-1273 boost and 2,670 and 1,930 for mRNA-Omicron, respectively. Similar increases against BA.2 were observed. Following either boost, 70%-80% of spike-specific B cells were cross-reactive against WA1 and Omicron. Equivalent control of virus replication in lower airways was observed following Omicron challenge 1 month after either boost. These data show that mRNA-1273 and mRNA-Omicron elicit comparable immunity and protection shortly after the boost.
Keywords: B cells; COVID-19; Omicron; SARS-CoV-2; T cells; antibody; boost; immune memory; mRNA vaccine; original antigenic sin.