tetano
Editor, Senior Moderator
Cell Host Microbe
. 2020 May 27;S1931-3128(20)30290-0.
doi: 10.1016/j.chom.2020.05.008. Online ahead of print.
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19
Annsea Park[SUP] 1 [/SUP], Akiko Iwasaki[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics or vaccines to this ongoing global threat, type I and type III interferons (IFNs) are currently being evaluated for their efficacy. Both the role of IFNs and the use of recombinant IFNs in two related, highly pathogenic coronaviruses, SARS-CoV and MERS-CoV, have been controversial in terms of their protective effects in the host. In this review, we describe the recent progress in our understanding of both type I and type III IFN-mediated innate antiviral responses against human coronaviruses and discuss the potential use of IFNs as a treatment strategy for COVID-19.
. 2020 May 27;S1931-3128(20)30290-0.
doi: 10.1016/j.chom.2020.05.008. Online ahead of print.
Type I and Type III Interferons - Induction, Signaling, Evasion, and Application to Combat COVID-19
Annsea Park[SUP] 1 [/SUP], Akiko Iwasaki[SUP] 2 [/SUP]
Affiliations
- PMID: 32464097
- DOI: 10.1016/j.chom.2020.05.008
Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics or vaccines to this ongoing global threat, type I and type III interferons (IFNs) are currently being evaluated for their efficacy. Both the role of IFNs and the use of recombinant IFNs in two related, highly pathogenic coronaviruses, SARS-CoV and MERS-CoV, have been controversial in terms of their protective effects in the host. In this review, we describe the recent progress in our understanding of both type I and type III IFN-mediated innate antiviral responses against human coronaviruses and discuss the potential use of IFNs as a treatment strategy for COVID-19.