tetano
Editor, Senior Moderator
Cell Host Microbe
. 2021 Oct 13;S1931-3128(21)00465-0.
doi: 10.1016/j.chom.2021.10.003. Online ahead of print.
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner
Roanne Keeton[SUP] 1 [/SUP], Simone I Richardson[SUP] 2 [/SUP], Thandeka Moyo-Gwete[SUP] 2 [/SUP], Tandile Hermanus[SUP] 2 [/SUP], Marius B Tincho[SUP] 1 [/SUP], Ntombi Benede[SUP] 1 [/SUP], Nelia P Manamela[SUP] 2 [/SUP], Richard Baguma[SUP] 3 [/SUP], Zanele Makhado[SUP] 2 [/SUP], Amkele Ngomti[SUP] 1 [/SUP], Thopisang Motlou[SUP] 2 [/SUP], Mathilda Mennen[SUP] 4 [/SUP], Lionel Chinhoyi[SUP] 4 [/SUP], Sango Skelem[SUP] 4 [/SUP], Hazel Maboreke[SUP] 5 [/SUP], Deelan Doolabh[SUP] 1 [/SUP], Arash Iranzadeh[SUP] 1 [/SUP], Ashley D Otter[SUP] 6 [/SUP], Tim Brooks[SUP] 6 [/SUP], Mahdad Noursadeghi[SUP] 7 [/SUP], James C Moon[SUP] 8 [/SUP], Alba Grifoni[SUP] 9 [/SUP], Daniela Weiskopf[SUP] 9 [/SUP], Alessandro Sette[SUP] 10 [/SUP], Jonathan Blackburn[SUP] 5 [/SUP], Nei-Yuan Hsiao[SUP] 11 [/SUP], Carolyn Williamson[SUP] 12 [/SUP], Catherine Riou[SUP] 12 [/SUP], Ameena Goga[SUP] 13 [/SUP], Nigel Garrett[SUP] 14 [/SUP], Linda-Gail Bekker[SUP] 15 [/SUP], Glenda Gray[SUP] 13 [/SUP], Ntobeko A B Ntusi[SUP] 16 [/SUP], Penny L Moore[SUP] 17 [/SUP], Wendy A Burgers[SUP] 18 [/SUP]
Affiliations
Abstract
The Johnson and Johnson Ad26.COV2.S single-dose vaccine represents an attractive option for coronavirus disease 2019 (COVID-19) vaccination in countries with limited resources. We examined the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity. We compared participants who were SARS-CoV-2 naive with those either infected with the ancestral D614G virus or infected in the second wave when Beta predominated. Prior infection significantly boosts spike-binding antibodies, antibody-dependent cellular cytotoxicity, and neutralizing antibodies against D614G, Beta, and Delta; however, neutralization cross-reactivity varied by wave. Robust CD4 and CD8 T cell responses are induced after vaccination, regardless of prior infection. T cell recognition of variants is largely preserved, apart from some reduction in CD8 recognition of Delta. Thus, Ad26.COV2.S vaccination after infection could result in enhanced protection against COVID-19. The impact of the infecting variant on neutralization breadth after vaccination has implications for the design of second-generation vaccines based on variants of concern.
Keywords: Ad26CoV2.S; Fc effector function; SARS-CoV-2; hybrid immunity; neutralization; vaccines; variants of concern.
. 2021 Oct 13;S1931-3128(21)00465-0.
doi: 10.1016/j.chom.2021.10.003. Online ahead of print.
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner
Roanne Keeton[SUP] 1 [/SUP], Simone I Richardson[SUP] 2 [/SUP], Thandeka Moyo-Gwete[SUP] 2 [/SUP], Tandile Hermanus[SUP] 2 [/SUP], Marius B Tincho[SUP] 1 [/SUP], Ntombi Benede[SUP] 1 [/SUP], Nelia P Manamela[SUP] 2 [/SUP], Richard Baguma[SUP] 3 [/SUP], Zanele Makhado[SUP] 2 [/SUP], Amkele Ngomti[SUP] 1 [/SUP], Thopisang Motlou[SUP] 2 [/SUP], Mathilda Mennen[SUP] 4 [/SUP], Lionel Chinhoyi[SUP] 4 [/SUP], Sango Skelem[SUP] 4 [/SUP], Hazel Maboreke[SUP] 5 [/SUP], Deelan Doolabh[SUP] 1 [/SUP], Arash Iranzadeh[SUP] 1 [/SUP], Ashley D Otter[SUP] 6 [/SUP], Tim Brooks[SUP] 6 [/SUP], Mahdad Noursadeghi[SUP] 7 [/SUP], James C Moon[SUP] 8 [/SUP], Alba Grifoni[SUP] 9 [/SUP], Daniela Weiskopf[SUP] 9 [/SUP], Alessandro Sette[SUP] 10 [/SUP], Jonathan Blackburn[SUP] 5 [/SUP], Nei-Yuan Hsiao[SUP] 11 [/SUP], Carolyn Williamson[SUP] 12 [/SUP], Catherine Riou[SUP] 12 [/SUP], Ameena Goga[SUP] 13 [/SUP], Nigel Garrett[SUP] 14 [/SUP], Linda-Gail Bekker[SUP] 15 [/SUP], Glenda Gray[SUP] 13 [/SUP], Ntobeko A B Ntusi[SUP] 16 [/SUP], Penny L Moore[SUP] 17 [/SUP], Wendy A Burgers[SUP] 18 [/SUP]
Affiliations
- PMID: 34688376
- DOI: 10.1016/j.chom.2021.10.003
Abstract
The Johnson and Johnson Ad26.COV2.S single-dose vaccine represents an attractive option for coronavirus disease 2019 (COVID-19) vaccination in countries with limited resources. We examined the effect of prior infection with different SARS-CoV-2 variants on Ad26.COV2.S immunogenicity. We compared participants who were SARS-CoV-2 naive with those either infected with the ancestral D614G virus or infected in the second wave when Beta predominated. Prior infection significantly boosts spike-binding antibodies, antibody-dependent cellular cytotoxicity, and neutralizing antibodies against D614G, Beta, and Delta; however, neutralization cross-reactivity varied by wave. Robust CD4 and CD8 T cell responses are induced after vaccination, regardless of prior infection. T cell recognition of variants is largely preserved, apart from some reduction in CD8 recognition of Delta. Thus, Ad26.COV2.S vaccination after infection could result in enhanced protection against COVID-19. The impact of the infecting variant on neutralization breadth after vaccination has implications for the design of second-generation vaccines based on variants of concern.
Keywords: Ad26CoV2.S; Fc effector function; SARS-CoV-2; hybrid immunity; neutralization; vaccines; variants of concern.