tetano
Editor, Senior Moderator
Cell Host Microbe
. 2024 Jan 29:S1931-3128(24)00007-6.
doi: 10.1016/j.chom.2024.01.003. Online ahead of print. Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site
Andrew J Thompson[SUP] 1 [/SUP], Nicholas C Wu[SUP] 2 [/SUP], Angeles Canales[SUP] 3 [/SUP], Chika Kikuchi[SUP] 1 [/SUP], Xueyong Zhu[SUP] 2 [/SUP], Beatriz Fernández de Toro[SUP] 4 [/SUP], Francisco J Cañada[SUP] 5 [/SUP], Charli Worth[SUP] 1 [/SUP], Shengyang Wang[SUP] 1 [/SUP], Ryan McBride[SUP] 1 [/SUP], Wenjie Peng[SUP] 1 [/SUP], Corwin M Nycholat[SUP] 1 [/SUP], Jesús Jiménez-Barbero[SUP] 6 [/SUP], Ian A Wilson[SUP] 7 [/SUP], James C Paulson[SUP] 8 [/SUP]
Affiliations
Hemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind α2-3-linked sialosides and must adapt to glycans with α2-6-linked sialic acids on human airway cells to transmit within the human population. Since their introduction during the 1968 pandemic, H3N2 viruses have evolved over the past five decades to preferentially recognize human α2-6-sialoside receptors that are elongated through addition of poly-LacNAc. We show that more recent H3N2 viruses now make increasingly complex interactions with elongated receptors while continuously selecting for strains maintaining this phenotype. This change in receptor engagement is accompanied by an extension of the traditional receptor-binding site to include residues in key antigenic sites on the surface of HA trimers. These results help explain the propensity for selection of antigenic variants, leading to vaccine mismatching, when H3N2 viruses are propagated in chicken eggs or cells that do not contain such receptors.
Keywords: H3N2; epistasis; glycan; hemagglutinin; host adaptation; human; influenza; receptor; receptor-binding site; sialic acid.
. 2024 Jan 29:S1931-3128(24)00007-6.
doi: 10.1016/j.chom.2024.01.003. Online ahead of print. Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site
Andrew J Thompson[SUP] 1 [/SUP], Nicholas C Wu[SUP] 2 [/SUP], Angeles Canales[SUP] 3 [/SUP], Chika Kikuchi[SUP] 1 [/SUP], Xueyong Zhu[SUP] 2 [/SUP], Beatriz Fernández de Toro[SUP] 4 [/SUP], Francisco J Cañada[SUP] 5 [/SUP], Charli Worth[SUP] 1 [/SUP], Shengyang Wang[SUP] 1 [/SUP], Ryan McBride[SUP] 1 [/SUP], Wenjie Peng[SUP] 1 [/SUP], Corwin M Nycholat[SUP] 1 [/SUP], Jesús Jiménez-Barbero[SUP] 6 [/SUP], Ian A Wilson[SUP] 7 [/SUP], James C Paulson[SUP] 8 [/SUP]
Affiliations
- PMID: 38307019
- DOI: 10.1016/j.chom.2024.01.003
Hemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind α2-3-linked sialosides and must adapt to glycans with α2-6-linked sialic acids on human airway cells to transmit within the human population. Since their introduction during the 1968 pandemic, H3N2 viruses have evolved over the past five decades to preferentially recognize human α2-6-sialoside receptors that are elongated through addition of poly-LacNAc. We show that more recent H3N2 viruses now make increasingly complex interactions with elongated receptors while continuously selecting for strains maintaining this phenotype. This change in receptor engagement is accompanied by an extension of the traditional receptor-binding site to include residues in key antigenic sites on the surface of HA trimers. These results help explain the propensity for selection of antigenic variants, leading to vaccine mismatching, when H3N2 viruses are propagated in chicken eggs or cells that do not contain such receptors.
Keywords: H3N2; epistasis; glycan; hemagglutinin; host adaptation; human; influenza; receptor; receptor-binding site; sialic acid.