tetano
Editor, Senior Moderator
Cell Death Dis
. 2024 Nov 28;15(11):863.
doi: 10.1038/s41419-024-07247-8. Blood matters: the hematological signatures of Coronavirus infection
Ayelen Toro[SUP] #[/SUP][SUP] 1 2 [/SUP], Ana P Arévalo[SUP] #[/SUP][SUP] 3 [/SUP], Marianoel Pereira-Gómez[SUP] #[/SUP][SUP] 4 5 [/SUP], Agustina Sabater[SUP] 6 7 8 [/SUP], Eric A Zizzi[SUP] 9 10 [/SUP], Paula Perbolianachis[SUP] 4 5 [/SUP], Gaston Pascual[SUP] 6 7 [/SUP], Sofia Lage-Vickers[SUP] 6 7 [/SUP], Jorge L Pórfido[SUP] 3 [/SUP], Ines Achinelli[SUP] 6 7 [/SUP], Rocio Seniuk[SUP] 6 7 [/SUP], Juan Bizzotto[SUP] 6 7 8 [/SUP], Pablo Sanchis[SUP] 6 7 8 [/SUP], Alvaro Olivera[SUP] 11 [/SUP], Alejandro Leyva[SUP] 12 13 [/SUP], Pilar Moreno[SUP] 4 5 [/SUP], Alicia Costábile[SUP] 4 5 14 15 [/SUP], Alvaro Fajardo[SUP] 4 5 [/SUP], Federico Carrión[SUP] 16 [/SUP], Martín Fló[SUP] 16 17 [/SUP], Natalia Olivero-Deibe[SUP] 16 [/SUP], Fernando Rodriguez[SUP] 18 [/SUP], Nicolas Nin[SUP] 18 [/SUP], Nicolas Anselmino[SUP] 19 [/SUP], Estefania Labanca[SUP] 19 [/SUP], Elba Vazquez[SUP] 6 7 [/SUP], Javier Cotignola[SUP] 6 7 [/SUP], Daniel F Alonso[SUP] 20 [/SUP], Maria P Valacco[SUP] 6 7 [/SUP], Marcelo Marti[SUP] 6 7 [/SUP], Francesco Gentile[SUP] 10 21 [/SUP], Artem Cherkasov[SUP] 22 [/SUP], Martina Crispo[SUP] 23 [/SUP], Gonzalo Moratorio[SUP] 24 25 [/SUP], Geraldine Gueron[SUP] 26 27 [/SUP]
Affiliations
Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through heme-interacting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for intervention.
. 2024 Nov 28;15(11):863.
doi: 10.1038/s41419-024-07247-8. Blood matters: the hematological signatures of Coronavirus infection
Ayelen Toro[SUP] #[/SUP][SUP] 1 2 [/SUP], Ana P Arévalo[SUP] #[/SUP][SUP] 3 [/SUP], Marianoel Pereira-Gómez[SUP] #[/SUP][SUP] 4 5 [/SUP], Agustina Sabater[SUP] 6 7 8 [/SUP], Eric A Zizzi[SUP] 9 10 [/SUP], Paula Perbolianachis[SUP] 4 5 [/SUP], Gaston Pascual[SUP] 6 7 [/SUP], Sofia Lage-Vickers[SUP] 6 7 [/SUP], Jorge L Pórfido[SUP] 3 [/SUP], Ines Achinelli[SUP] 6 7 [/SUP], Rocio Seniuk[SUP] 6 7 [/SUP], Juan Bizzotto[SUP] 6 7 8 [/SUP], Pablo Sanchis[SUP] 6 7 8 [/SUP], Alvaro Olivera[SUP] 11 [/SUP], Alejandro Leyva[SUP] 12 13 [/SUP], Pilar Moreno[SUP] 4 5 [/SUP], Alicia Costábile[SUP] 4 5 14 15 [/SUP], Alvaro Fajardo[SUP] 4 5 [/SUP], Federico Carrión[SUP] 16 [/SUP], Martín Fló[SUP] 16 17 [/SUP], Natalia Olivero-Deibe[SUP] 16 [/SUP], Fernando Rodriguez[SUP] 18 [/SUP], Nicolas Nin[SUP] 18 [/SUP], Nicolas Anselmino[SUP] 19 [/SUP], Estefania Labanca[SUP] 19 [/SUP], Elba Vazquez[SUP] 6 7 [/SUP], Javier Cotignola[SUP] 6 7 [/SUP], Daniel F Alonso[SUP] 20 [/SUP], Maria P Valacco[SUP] 6 7 [/SUP], Marcelo Marti[SUP] 6 7 [/SUP], Francesco Gentile[SUP] 10 21 [/SUP], Artem Cherkasov[SUP] 22 [/SUP], Martina Crispo[SUP] 23 [/SUP], Gonzalo Moratorio[SUP] 24 25 [/SUP], Geraldine Gueron[SUP] 26 27 [/SUP]
Affiliations
- PMID: 39609423
- PMCID: PMC11605097
- DOI: 10.1038/s41419-024-07247-8
Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well understood. Employing a dual-modality approach, we integrated findings from a Murine Hepatitis Virus (MHV) infection model with corroborative clinical data to investigate the pervasive reach of Coronaviruses. The novel presence of viral particles within red blood cells (RBCs) was demonstrated via high-resolution transmission electron microscopy, with computational modeling elucidating a potential heme-mediated viral entry mechanism via Spike protein affinity. Our data affirm viral localization in RBCs, suggesting heme moieties as facilitators for cellular invasion. Exacerbation of MHV pathology upon hemin administration, contrasted with chloroquine-mediated amelioration, underscoring a heme-centric pathway in disease progression. These observations extend the paradigm of Coronavirus pathogenicity to include hemoprotein interactions. This study casts new light on the systemic invasion capabilities of Coronaviruses, linking RBC hemoproteins with viral virulence. The modulation of disease severity through heme-interacting agents heralds a promising avenue for COVID-19 therapeutics. Our findings propose a paradigm shift in the treatment approach, leveraging the virus-heme interplay as a strategic hinge for intervention.